Association between neuroimaging findings and neurological sequelae in patients with congenital cytomegalovirus infection

Castellanos, María Escobar; Navazo, Sara de la Mata; Bermejo, Marta; Morin, M; Martín, Yolanda; Saavedra-Lozano, Jesús; Herrero, M.C. Miranda; Valderrama, Estíbaliz Barredo; Castro, P. Castro de; Vázquez-López, M

doi:10.1016/j.nrleng.2018.11.011

Cited by 6 publications

(20 citation statements)

References 23 publications

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“…These include prospective ( n = 20), 18 , 20 , 21 , 24 , 25 , 26 , 27 , 28 , 30 , 32 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 45 retrospective ( n = 7) 22 , 23 , 29 , 31 , 35 , 43 , 44 and cross‐sectional studies ( n = 1), 19 conducted in 18 different countries; by region, 16 studies were conducted in Europe, 18 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 28 , 30 , 32 , 34 , 36 , 43 , 44 , 45 five in East Asia, 27 , 29 , 37 , 38 , 39 four in North America 31 , 40 , 41 ...…”

Section: Resultsmentioning

confidence: 99%

“…The age at last follow‐up ranged between 1 month and 18 years, with 6/28 studies (from three cohorts) including populations with at least 5 years of follow‐up 40 , 41 , 42 , 43 , 44 , 45 (duration unclear for one study). 19 cCMV was identified among children in the included studies via population screening ( n = 13), 18 , 21 , 27 , 29 , 33 , 34 , 38 , 39 , 41 , 42 , 43 , 44 , 45 diagnostic testing of populations with suspected infection or clinical indications ( n = 4), 19 , 20 , 22 , 26 testing of infants born to women with primary CMV infection during pregnancy ( n = 5) 23 , 24 , 32 , 35 , 37 or a combination of these ( n = 6). 25 , 28 , 30 , 31 , 36 , 40 Four studies only included infants born to women with primary maternal CMV infection, 23 , 24 , 32 , 35 whereas eight studies reported the proportion of children born to women with primary and non‐primary maternal CMV infections during pregnancy, 21 , 26 , 28 , 30 , 31 , 33 ...…”

Section: Resultsmentioning

confidence: 99%

“…The majority of studies did not report type or timing of maternal infection ( n = 16). 18 , 19 , 20 , 22 , 25 , 27 , 29 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 …”

Section: Resultsmentioning

confidence: 99%

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What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review

Smyrli,

Raveendran,

Walter

et al. 2024

Reviews in Medical Virology

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Congenital cytomegalovirus (cCMV) is among the most common congenital infections globally. Of 85%–90% cCMV‐infected infants without symptoms at birth, 10%–15% develop sequelae, most commonly sensorineural hearing loss (SNHL); their childhood neurodevelopmental outcomes are less well understood. Embase and MEDLINE were searched for publications from 16th September 2016 to 9th February 2024 to identify studies reporting primary data on neurodevelopmental outcomes in children with asymptomatic cCMV (AcCMV), measured using assessment tools or as evaluated by the study investigators, clinicians, educators, or parents. The Newcastle‐Ottawa scale was applied to studies to assess risk of bias. Of 28 studies from 18 mostly high‐income countries, there were 5‐109 children with AcCMV per study and 6/28 had a mean or median age at last follow‐up of ≥5 years. Children with AcCMV had better neurodevelopmental outcomes than children with symptomatic cCMV in 16/19 studies. Of 9/28 studies comparing AcCMV with CMV‐uninfected children, six reported similar outcomes whilst three reported differences limited to measures of full‐scale intelligence and receptive vocabulary among children with AcCMV and SNHL, or more generally in motor impairment. Common limitations of studies for our question were a lack of cCMV‐uninfected controls, heterogeneous definitions of AcCMV, lack of focus on neurodevelopment, selection bias and inadequate follow‐up. There was little evidence of children with AcCMV having worse neurodevelopmental outcomes than CMV‐uninfected children, but this conclusion is limited by study characteristics and quality; findings highlight the need for well‐designed and standardised approaches to investigate long‐term sequelae.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review

Smyrli,

Raveendran,

Walter

et al. 2024

Reviews in Medical Virology

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“… Новорожденному с подтвержденной врожденной ЦМВИ при наличии неврологических нарушений и УЗпатологических изменений головного мозга рекомендуется проведение МРТ головного мозга для уточнения объема и характера структурных поражений ЦНС [45,48,[108][109][110][111].…”

Section: уровень убедительности рекомендаций а (уровень достоверности...unclassified

Congenital cytomegalovirus infection (guideline)

Balashova,

Vasil’ev,

Vaynshteyn

et al. 2023

Neonatology: News, Opinions, Training

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“…Neuroimaging plays an important role in the definition of brain damage but can also give prognostic indications, since US and MR have high sensitivity and specificity for predicting neurological sequelae. In fact, there are many studies that have correlated the alterations identified by MRI with neurodevelopment in order to provide the clinician and families with more precise information to guide an early and correct treatment and follow-up [ 23 ]. Interestingly, Colonna et al demonstrated that both asymptomatic and symptomatic newborns affected by cCMV develop long-term sequelae independent of the trimester of maternal infection [ 5 ].…”

Section: Torchmentioning

confidence: 99%

From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review

et al. 2022

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Congenital infections represent a challenging and varied clinical scenario in which the brain is frequently involved. Therefore, fetal and neonatal neuro-imaging plays a pivotal role in reaching an accurate diagnosis and in predicting the clinical outcome. Congenital brain infections are characterized by various clinical manifestations, ranging from nearly asymptomatic diseases to syndromic disorders, often associated with severe neurological symptoms. Brain damage results from the complex interaction among the infectious agent, its specific cellular tropism, and the stage of development of the central nervous system at the time of the maternal infection. Therefore, neuroradiological findings vary widely and are the result of complex events. An early detection is essential to establishing a proper diagnosis and prognosis, and to guarantee an optimal and prompt therapeutic perinatal management. Recently, emerging infective agents (i.e., Zika virus and SARS-CoV2) have been related to possible pre- and perinatal brain damage, thus expanding the spectrum of congenital brain infections. The purpose of this pictorial review is to provide an overview of the current knowledge on fetal and neonatal brain neuroimaging patterns in congenital brain infections used in clinical practice.

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Association between neuroimaging findings and neurological sequelae in patients with congenital cytomegalovirus infection

Cited by 6 publications

References 23 publications

What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review

What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review

Congenital cytomegalovirus infection (guideline)

From Fetal to Neonatal Neuroimaging in TORCH Infections: A Pictorial Review

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