Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study

Yu, Yun; Cui, Weihua; Cheng, Chan; Lu, Yu; Zhang, Qing; Han, Ruquan

doi:10.12998/wjcc.v9.i35.10816

Cited by 5 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The NLR re ects the balance of neutrophils and lymphocytes in the body and is more accurate and stable than neutrophils and lymphocytes 29 . In recent years, it has been considered an important in ammatory response marker for diagnosing and evaluating patient prognosis [30][31][32][33] . In this study, we found that the NLR within 48 hours before surgery is also an important predictor of PPCs in children undergoing thoracic surgery requiring OLV, which is consistent with previous reports 34,35 .…”

Section: Discussionmentioning

confidence: 99%

A predictive model of pediatric postoperative pulmonary complications following one-lung ventilation

Wang,

Xiao,

et al. 2024

Preprint

View full text Add to dashboard Cite

Since the disparities in respiratory anatomy and physiology between children and adults, children are more susceptible to postoperative pulmonary complications (PPCs) after one-lung ventilation (OLV). Hypothesizing that the incidence of PPCs could be predicted using easily accessible perioperative variables, we aimed to develop a nomogram specifically for children receiving thoracic surgery with OLV. The outcome of this study was the incidence of PPCs. Univariate analysis and the least absolute shrinkage and selection operator regression model were applied to select the most relevant prognostic predictors. Multivariable logistic regression was used to develop a nomogram based on the selected prediction factors. Internal validation was conducted to evaluate its performance. Following screening, a total of 249 children were ultimately included in the study. Among them, 89 (35.7%) presented PPCs. Four predictive factors were ultimately chosen for nomogram development: preoperative neutrophil-to-lymphocyte ratio, intraoperative ventilation mode, maximum peak airway pressure, and minimum oxygenation index during OLV. By incorporating of these four factors, the nomogram achieved an area under the curve of 0.846 [95% confidence interval, 0.797-0.894) with well-fitted calibration curves. In conclusion, this nomogram, based on four factors, predicts pediatric PPCs after OLV, enabling early risk assessment and interventions for better outcomes. This study is registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2300072042, Date of Registration: 1/6/2023)

show abstract

Section: Discussionmentioning

confidence: 99%

A predictive model of pediatric postoperative pulmonary complications following one-lung ventilation

Wang,

Xiao,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Этиология послеоперационного повышения NT-proBNP в настоящее время неизвестна и может быть многофакторной [59]. Появились также единичные работы по изучении других биомаркеров: соотношение тромбоцитов к лимфоцитам и нейтрофилов к лимфоцитам, показатели системного воспаления [60][61][62], уровень миоглобина [63] были ассоциированы с периоперационными осложнениями при некардиальных операциях. Однако требуются дополнительные более масштабные исследования для изучения возможности их использования в клинике.…”

Section: биомаркерыunclassified

Assessment and Correction of the Cardiac Complications Risk in Non-cardiac Operations – What's New?

Sumin

2022

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Cardiovascular complications after non-cardiac surgery are the leading cause of 30-day mortality. The need for surgical interventions is approximately 5,000 procedures per 100,000 population, according to experts, the risks of non-cardiac surgical interventions are markedly higher in the elderly. It should be borne in mind that the aging of the population and the increased possibilities of medicine inevitably lead to an increase in surgical interventions in older people. Recent years have been characterized by the appearance of national and international guidelines with various algorithms for assessing and correcting cardiac risk, as well as publications on the validation of these algorithms. The purpose of this review was to provide new information about the assessment and correction of the risk of cardiac complications in non-cardiac operations. Despite the proposed new risk assessment scales, the RCRI scale remains the most commonly used, although for certain categories of patients (with oncopathology, in older age groups) the possibility of using specific questionnaires has been shown. In assessing the functional state, it is proposed to use not only a subjective assessment, but also the DASI questionnaire, 6-minute walking test and cardiopulmonary exercise test). At the next stage, it is proposed to evaluate biomarkers, primarily BNP or NT-proBNP, with a normal level – surgery, with an increased level – either an additional examination by a cardiologist or perioperative troponin screening. Currently, the prevailing opinion is that there is no need to examine patients to detect hidden lesions of the coronary arteries (non-invasive tests, coronary angiography), since this leads to excessive examination of patients, delaying the implementation of non-cardiac surgery. The extent to which this approach has an advantage over the previously used one remains to be studied.

show abstract

“…The patients mentioned above are at high risk for postoperative AKI, however, our study included a wider range of patients. Unlike these studies, Yu and his colleagues [30] focused on the postoperative NLR and found that NLR within 24 h after surgery was significantly correlated with major postoperative complications in patients undergoing carotid endarterectomy. By using the optimal cut-off value of preoperative NLR obtained in our study, the rate of missed diagnosis is lower, which enables clinicians to be more alert to the occurrence of postoperative AKI in patients, strengthening preoperative prevention and management (e.g., avoid the use of nephrotoxic drugs or angiography) of postoperative renal function problems.…”

Section: Plos Onementioning

confidence: 99%

Preoperative Neutrophil-Lymphocyte Ratio for predicting surgery-related acute kidney injury in non-cardiac surgery patients under general anaesthesia: A retrospective cohort study

Tang

Chen

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Background This study was conducted to investigate the relationship between the Neutrophil-Lymphocyte Ratio (NLR) and the incidence of surgery-related acute kidney injury (AKI) in non-cardiac surgery patients under general anaesthesia. Methods In this retrospective study, 5057 patients from Third Xiangya hospital from January 2012 to December 2016 and 1686 patients from Second Xiangya hospital from January 2016 to December 2016 for non-cardiac surgery under general anesthesia were included. According to receiver operating characteristic (ROC) curve constructed by NLR for postoperative AKI, the cut-off point was obtained as the basis for grouping low or high NLR. The baseline characteristics of two sets were compared with each other. A multi-factor model was constructed by Least absolute shrinkage and selection operator (LASSO) method with the training set, and verified by outside validation set. Results 243 patients (3.604%) developed postoperative AKI. The ROC curve showed that the AUC of the NLR for predicting postoperative AKI in non-cardiac surgery was 0.743 (95% CI, 0.717–0.769), and the cut-off value was 3.555 (sensitivity, 86.4%; specificity 51.9%). There was no significant difference in the baseline characteristics of training set and validation set. The AUC in the training set was 0.817 (95% CI, 0.784–0.850), and the AUC in the validation set was 0.804 (95% CI, 0.749–0.858), the AUC deviation was 0.012 (P > 0.05) from validation set, and the likelihood ratio test showed P < 0.05. Conclusion This study showed that preoperative high NLR (NLR≥3.555) was an independent risk factor associated with postoperative AKI (OR, 2.410; 95% CI, 1.371–4.335) in patients for non-cardiac surgery under general anesthesia.

show abstract

Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study

Cited by 5 publications

References 38 publications

A predictive model of pediatric postoperative pulmonary complications following one-lung ventilation

A predictive model of pediatric postoperative pulmonary complications following one-lung ventilation

Assessment and Correction of the Cardiac Complications Risk in Non-cardiac Operations – What's New?

Preoperative Neutrophil-Lymphocyte Ratio for predicting surgery-related acute kidney injury in non-cardiac surgery patients under general anaesthesia: A retrospective cohort study

Contact Info

Product

Resources

About