Association Between Newborn Birth Weight and the Risk of Postpartum Maternal Venous Thromboembolism

Abstract

Background-Postpartum venous thromboembolism (VTE) is a potentially fatal and preventable event leading to substantial short-and long-term morbidity. We sought to evaluate whether the delivery of term newborns of low or high birth weight was associated with greater risks of VTE. Methods and Results-In a population-based case-control study conducted in Washington State from 1987 through 2011, cases of hospitalized VTE within 3 months of delivery were identified by using selected International Classification of Diseases, Ninth Revision, Clinical Modification codes. Controls were randomly selected postpartum women without VTE, matched on birth year. Birth weight and other maternal and pregnancy characteristics were extracted from birth certificate data. Among term live singleton deliveries, we compared the risk of VTE for mothers of newborns of low and high birth weights (<2500 g and >4000 g, respectively) versus mothers of newborns of normal birth weight (2500-4000 g). Logistic regression models were adjusted for maternal age, race, education, body mass index, parity, delivery methods, gestational length, smoking, gestational diabetes mellitus, and preeclampsia. Patients with VTE (n=547) were older, had a higher body mass index, and experienced more pregnancy-related complications than controls (n=9482).In comparison with mothers of newborns with normal birth weight, mothers of newborns with low birth weight had a 3-fold increased risk of VTE, which persisted after multivariable adjustment (odds ratio, 2.98; 95% confidence interval, 1.80-4.93). Mothers of newborns with high birth weight had only a slightly increased risk of VTE, which was attenuated after multivariable adjustment (odds ratio, 1.26; 95% confidence interval, 0.99-1.61). Conclusions-The delivery of a newborn with low birth weight is associated with a 3-fold increased risk of maternal postpartum VTE. This should be considered when assessing VTE risk at delivery.

Passive smoking and stroke in men and women: a national population-based case-control study in China

“…Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a non-conditional logistic regression model for estimating the effects of exposure to passive smoking on the risk of death from stroke and conducting a trend test 30 31 32 . The initial models were adjusted for age only in each subgroup such as gender, smoking status, and age spans.…”

Risk factors for pregnancy-associated venous thromboembolism in Singapore

“…Variations in the strength of pregnancyassociated VTE risk factors such as obesity and caesarean section have also been reported [14]. The current risk assessment model does not include other factors which have been shown to be associated with an increased risk of pregnancy-associated VTE, such as non-O blood group [15] and newborn low birth weight (LBW) [16]. Lastly, the paucity of data on pregnancy-associated VTE and lack of validation in the racially diverse Singaporean population limits the applicability of the current risk assessment model.…”

Epidemiologie, Risikofaktoren und Risikostratifizierung venöser Thromboembolien (VTE) in Schwangerschaft und Wochenbett

“…Eine jüngste, bevölkerungsbasierte case-control-Studie aus den USA konnte zeigen, das niedriges Geburtsgewicht des Kindes ( < 2500 g) im Vergleich zu normalem Geburtsgewicht (2500-4000 g) als unabhängiger Risikofaktor für postpartale VTE mit einer 3-fachen Risikoerhöhung assoziiert ist [88] [14,65] übereinstimmt (aOR 6,0 bzw. 6,2).…”