Association between nonalcoholic fatty liver disease and <i>Helicobacter pylori</i> infection in Dali City, China

Yu, Bocheng; Li, Min; Zhao, Wei‐Dong

doi:10.15537/smj.2021.42.7.20210040

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…The main characteristics of the observational studies included in the meta‐analysis are summarized in Table 1 for cross‐sectional studies and Table 2 for longitudinal studies. Twenty‐four studies 31–54 had a cross‐sectional design, whereas four studies 55–58 had a longitudinal design. Regarding the cross‐sectional studies (Table 1), twelve studies were carried out in China, two in Japan, two in the USA, two in South Korea, one in Austria, one in Bangladesh, one in Egypt, one in Greece, one in Guatemala and one in Iran, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 1 shows the forest plot and pooled estimates of the effect of H. pylori infection on the risk of MASLD in 24 cross‐sectional studies 31–54 . Overall, these studies included a total of 209 439 middle‐aged individuals (58% men; mean age 49 ± 8 years; BMI 25.3 ± 2.4 kg/m 2 ; ~95% from Asian countries), 27.5% ( n = 62 628) of whom had a diagnosis of MASLD and 38.2% had a diagnosis of prior or active H. pylori infection.…”

Section: Resultsmentioning

confidence: 99%

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Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Mantovani,

Lando,

Borella

et al. 2024

Liver International

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BackgroundRecent observational studies examining the association between Helicobacter pylori infection and the risk of metabolic dysfunction‐associated steatotic liver disease (MASLD) have reported conflicting results. We performed a meta‐analysis to quantify the magnitude of the association between H. pylori infection and the risk of MASLD.MethodsWe systematically searched three large electronic databases to identify eligible observational studies (published up to 30 November 2023) in which liver biopsy, imaging methods or blood‐based biomarkers/scores were used for diagnosing MASLD. Data from selected studies were extracted, and meta‐analysis was performed using common and random‐effects modelling. Statistical heterogeneity among published studies, subgroup analyses, meta‐regression analyses and publication bias were assessed.ResultsA total of 28 observational studies (24 cross‐sectional and 4 longitudinal studies) were identified, including 231 291 middle‐aged individuals of predominantly Asian ethnicity (~95%). Meta‐analysis of cross‐sectional studies showed that H. pylori infection was significantly associated with a small increase in the risk of prevalent MASLD (n = 24 studies; random‐effects odds ratio 1.11, 95% CI 1.05–1.18; I2 = 63%). Meta‐analysis of data from longitudinal studies showed that H. pylori infection was significantly associated with an increased risk of developing incident MASLD over a mean 5‐year follow‐up (n = 4 studies; random‐effects odds ratio 1.20, 95%CI 1.08–1.33; I2 = 44%). Sensitivity analyses did not modify these results. The funnel plot did not reveal any significant publication bias.ConclusionsH. pylori infection is associated with a mildly increased risk of prevalent and incident MASLD. Further well‐designed prospective and mechanistic studies are required to better decipher the complex link between H. pylori infection and the risk of MASLD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Mantovani,

Lando,

Borella

et al. 2024

Liver International

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“…Twenty-five studies involving 117,458 participants were included ( Table 1 ). This review contained two cohort studies ( 35 , 36 ), 17 cross-sectional studies ( 3 , 25 – 27 , 29 , 37 – 39 , 41 – 47 , 49 , 52 ), and six case-control studies ( 28 , 40 , 48 , 50 , 51 , 53 ). These studies were published between 2013 and 2021, three of which were conference abstracts ( 43 , 47 , 54 ).…”

Section: Resultsmentioning

confidence: 99%

Association between Helicobacter pylori infection and non-alcoholic fatty liver disease for Asian and non-Asian population: A systematic review and meta-analysis

Chu²,

Yan³

et al. 2022

Front. Public Health

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BackgroundSeveral studies have revealed a positive correlation between a Helicobacter pylori (HP) infection and the risk of non-alcoholic fatty liver disease (NAFLD). This meta-analysis was conducted to explore further the relationship between HP infection and NAFLD in the Asian and non-Asian populations.MethodsRelevant studies published from inception to July 22, 2021, in the following databases: PubMed, EMBASE, the Cochrane library, and Web of Science were comprehensively searched. The odds ratio (OR) and hazard ratio (HR) with a 95% confidence interval (95%CI) were pooled by the random-effects model or fixed-effects model. Additionally, subgroup and sensitivity analyses were performed. The funnel plot and the Egger test were used to estimate publication bias.ResultsThis meta-analysis included 25 studies involving 107,306 participants. Positive associations between HP infection and NAFLD were found both for the Asian (OR = 1.30, 95% CI: 1.13–1.49, P < 0.01; I2 = 94.30%, P < 0.01) and non-Asian populations (OR = 1.42, 95% CI: 1.04–1.94, P = 0.03; I2 = 44.90%, P = 0.09). Moreover, similar results were observed in the Asian female group (OR = 1.31, 95% CI: 1.17–1.46, P < 0.01; I2 = 46.30%, P = 0.07) but not for the Asian male group. Subgroup analyses for the Asian population showed that there were differences in the association among NAFLD diagnosis methods (P < 0.01) and the study design (P < 0.01). However, subgroup and sensitivity analyses results showed that the association for the non-Asian population was not stable enough.ConclusionsThe data obtained in this systematic review and meta-analysis suggested that an HP infection was associated with an increased risk of NAFLD for Asian and non-Asian populations. However, the association was not found for Asian males. Further studies are required to establish the causal association, especially for the non-Asian population.Systematic review registrationIdentifier: CRD42021266871.

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“…On the other hand, while Yan in Bali found that the infection of H. pylori represents an independent risk factor for NAFLD [ 25 ], Wang et al observed in an impressive study on 71,633 participants in China that the same infection was not a risk factor for liver function damage in patients with NAFLD (AST, p = 0.911; ALT, p = 0.237) [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Liver Cytolysis in Children with Helicobacter pylori Infection

Lupu

Miron²,

Cianga³

et al. 2022

Children

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(1) Background: The relationship between Helicobacter pylori (H. pylori) infection and liver disease has been discussed for many years, but the association between the infection and liver cytolysis in children has been insufficiently explored. In our study, we evaluate this relationship in a pediatric population from the northeast of Romania. (2) Methods: A retrospective study of children with H. pylori infection and liver cytolysis was conducted on a group of 1757 children, admitted to a pediatric gastroenterology regional center in northeast Romania over 3 years. (3) Results: Liver cytolysis syndrome was present in 112 children of both sexes. Of the 112 children, 20 children (17.9%) also had H. pylori infection. In the statistical analysis, we noted a significant association between liver cytolysis syndrome and H. pylori infection (χ2; p < 0.001). (4) Conclusions: This relationship requires further in-depth studies that also consider certain parameters that may influence the results of these correlations. In addition, we point out the need for further analyses evaluating, in terms of the histopathological changes in each liver disease, the efficacy of H. pylori eradication.

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Association between nonalcoholic fatty liver disease and Helicobacter pylori infection in Dali City, China

Cited by 10 publications

References 28 publications

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Association between Helicobacter pylori infection and non-alcoholic fatty liver disease for Asian and non-Asian population: A systematic review and meta-analysis

The Prevalence of Liver Cytolysis in Children with Helicobacter pylori Infection

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