Association between novelty‐seeking and the dopamine D3 receptor gene in bipolar patients: A preliminary report

Staner, Luc; Hilger, Christiane; Hentges, F.; Monreal, José Jiménez; Hoffmann, A.; Couturier, M.; Bon, Olivier Le; Stefos, Grigori; Souery, D.; Mendlewicz, Julien

doi:10.1002/(sici)1096-8628(19980328)81:2<192::aid-ajmg12>3.3.co;2-i

Cited by 17 publications

(17 citation statements)

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“…An unexpected result was the correlation between novelty seeking and poor mental health. Prior studies have shown an association between novelty seeking and bipolar disorders, 34,35 but ours is the first to note an association with impulsive non-conformity. Further studies of the relationship between psychosis and affective disorders may be warranted.…”

Section: Discussioncontrasting

confidence: 46%

How to tell a happy from an unhappy schizotype: personality factors and mental health outcomes in individuals with psychotic experiences

Alminhana

Farias

Claridge

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: It is unclear why some individuals reporting psychotic experiences have balanced lives while others go on to develop mental health problems. The objective of this study was to test if the personality traits of harm avoidance, self-directedness, and self-transcendence can be used as criteria to differentiate healthy from unhealthy schizotypal individuals. Conclusion: Personality features are important criteria to distinguish between pathology and mental health in individuals presenting high levels of anomalous experiences (AEs). While self-directedness is a protective factor, both harm avoidance and novelty seeking were predictors of negative mental health outcomes. We suggest that the impact of AEs on mental health is moderated by personality factors.

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Section: Discussioncontrasting

confidence: 46%

How to tell a happy from an unhappy schizotype: personality factors and mental health outcomes in individuals with psychotic experiences

Alminhana

Farias

Claridge

et al. 2016

Rev. Bras. Psiquiatr.

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“…38 DRD3 has also been linked to neuroticism and behavioral inhibition; however, this result has not been reproduced. 39,40 The other highly ranked SNPs for Agreeableness included rs11219218 (P ¼ 1.6 Â 10 À5 ), which is located 5 kb upstream of SCN3B and is responsible for generating and propagating action potentials in neurons and muscle. We also identified rs11219218 as being significantly associated with this trait (P ¼ 0.02); however, the GWA study showed an opposite trend.…”

Section: Agreeablenessmentioning

confidence: 99%

Genome-wide association study of the five-factor model of personality in young Korean women

et al. 2013

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Personality is a determinant of behavior and lifestyle associated with health and human diseases. Although personality is known to be a heritable trait, its polygenic nature has made the identification of genetic variants elusive. We performed a genome-wide association study on 1089 Korean women aged 18-40 years whose personality traits were measured with the Revised NEO Personality Inventory for the five-factor model of personality. To reduce environmental factors that may influence personality traits, this study was restricted to young adult women. In the discovery phase, we identified variants of PTPRD (protein tyrosine phosphatase, receptor type D) that associated this gene with the Openness domain. Other genes that were previously reported to be associated with neurological phenotypes were also associated with personality traits. In particular, DRD1 and ORIA2 were linked to Neuroticism, NKAIN2 with Extraversion, HTR5A with Openness and DRD3 with Agreeableness. Data from our replication study of 2090 subjects confirmed the association between ORIA2 and Neuroticism. We first identified and confirmed a novel region on ORIA2 associated with Neuroticism. Candidate genes for psychiatric disorders were also enriched. These findings contribute to our understanding of the genetic architecture of personality traits and provide critical clues to the neurobiological mechanisms that influence them.

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“…DRD3 has been implicated by association studies as a possible candidate gene for a number of neuropsychiatric disorders including schizophrenia, 2 alcoholism, 16,17 cocaine abuse, 18 bipolar illness, 19,20 Tourette syndrome, 21 opiate dependence, 22 novelty seeking, 23 anorexia nervosa, 24 Parkinson's disease 25 and others. In most cases the results have been inconclusive, partly due to small subject numbers.…”

Section: Discussionmentioning

confidence: 99%

Characterisation, mutation detection, and association analysis of alternative promoters and 5′ UTRs of the human dopamine D3 receptor gene in schizophrenia

et al. 2002

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The dopamine D 3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported associations between polymorphisms in DRD3 and these disorders, but these findings may have reflected linkage disequilibrium with pathogenic variants that are further upstream. We have isolated and sequenced approximately 9 kb of genomic sequence upstream of the human DRD3 translational start site. Using 5Ј RACE, we have identified within this region three additional exons and two putative promoter regions which show promoter activity in three different cell lines. A 5Ј UTR identified only in lymphoblasts is spread over three exons and is 353 bp long. A second 5Ј UTR, found in adult and fetal brain, lymphocytes, kidney and placenta is spread over two exons and is 516 bp long. A 260-bp sequence within this 9 kb corresponds to a previously reported EST, but corresponding mRNA could not be found in the tissues above. The EST, 5Ј UTRs and putative promoter regions have been analysed for polymorphisms, revealing 10 single nucleotide polymorphisms, seven of which were tested for association in a large sample of unrelated patients with schizophrenia and matched controls. No associations were observed with schizophrenia. In addition we failed to replicate previous findings of association with homozygosity of the Ser9Gly variant. The results from this study imply that neither the coding nor the regulatory region of DRD3 plays a major role in predisposition to schizophrenia.

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Association between novelty‐seeking and the dopamine D3 receptor gene in bipolar patients: A preliminary report

Cited by 17 publications

References 0 publications

How to tell a happy from an unhappy schizotype: personality factors and mental health outcomes in individuals with psychotic experiences

How to tell a happy from an unhappy schizotype: personality factors and mental health outcomes in individuals with psychotic experiences

Genome-wide association study of the five-factor model of personality in young Korean women

Characterisation, mutation detection, and association analysis of alternative promoters and 5′ UTRs of the human dopamine D3 receptor gene in schizophrenia

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