Association Between Obesity and Cancer Mortality: An Internal Medicine Outpatient Clinic Perspective

Ramdass, Vede; Caskey, Elizabeth; Sklarz, Tammarah; Ajmeri, Saaniya; Patel, Vaishali; Balogun, Ayobamidele; Pomary, Victor; Hall, Jillian; Qari, Omar; Tripathi, Rahul; Hunter, Krystal; Roy, Satyajeet

doi:10.14740/jocmr4543

Cited by 9 publications

(6 citation statements)

References 63 publications

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“…It is worth noting, however, that some studies observed that HbA1c was positively associated with cancer mortality. 45,46 Many guidelines have started to recommend non-fasting lipids (total, HDL & LDL cholesterol as well as triglyceride) as the standard for cardiovascular risk assessment. 47,48 The current study suggests that non-fasting glucose (PPG4-7.9h) may be used for cancer mortality risk assessment.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Plasma Glucose and Associated Cancer Mortality

Wang,

Fang,

Habenicht

et al. 2024

Preprint

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BACKGROUND This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults. METHODS This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up to December 31, 2019. The experimental exposures were levels of plasma glucose, including PPG with a fasting time of 0-3.9 h (PPG0-3.9h) and 4-7.9 h (PPG4-7.9h), plasma glucose with a fasting time ≥ 8 h (PGfasting), and plasma glucose at 2 h after oral glucose tolerance test (PG2hOGTT). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazards models. RESULTS A 1-natural-log-unit increase in PPG4-7.9h was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50-7.00]. However, PPG0-3.9h, PGfasting, PG2hOGTT, hemoglobin A1c, and insulin were not significantly associated with cancer mortality. The positive association of PPG4-7.9h with cancer mortality remained in those without a prior diagnosis of cancer. CONCLUSIONS High PPG4-7.9h is associated with a higher cancer mortality risk in US adults. Lowering PPG4-7.9h may reduce cancer mortality.

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Section: Discussionmentioning

confidence: 99%

Postprandial Plasma Glucose and Associated Cancer Mortality

Wang,

Fang,

Habenicht

et al. 2024

Preprint

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“…Only a few studies have evaluated the association between Hba1c levels and the mortality of multiple cancers [ 20 , 32 , 33 , 34 ]. A previous study with 2,686 participants without a history of diabetes and a mean duration of follow-up of 7.54 ± 2.1 years failed to show any significant increase in cancer mortality in the HbA1c < 6.5% group [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Glycosylated Hemoglobin Level and Cancer-Related Mortality in Patients without Diabetes

Yoo

Lee

et al. 2022

JCM

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Background: Previous studies have reported that abnormal glucose metabolism is associated with poor cancer outcomes. Glycated hemoglobin A1c (HbA1c) is an important indicator of glucose metabolism. This study aimed to investigate the relationship between nondiabetic HbA1c levels and cancer-related mortality. Methods: This was a retrospective cohort study of Koreans who attended an annual or biennial health checkup program. The study group was categorized based on the quintile of HbA1c level (Q1, 3.0–5.1%; Q2, 5.2–5.3%; Q3, 5.4%; Q4, 5.5–5.6%, Q5, 5.7–6.4%). Cancer-related mortality was determined using the mortality data from the Korea National Statistical Office. Participants with an established diagnosis of diabetes or cancer were excluded. Cancer-related mortality was assessed depending on each HbA1c level with adjustment for factors that could influence mortality. Results: A total of 589,457 participants were included in this study. During a median follow-up duration of 6.99 years, 1,712 cancer-related deaths were reported. The risk of cancer-related mortality was significantly higher in the Q5 group (hazard ratio (HR) 1.23, range 1.02–1.47 in model 1; HR 1.25, range 1.04–1.50 in model 2). HbA1c levels were linearly associated with cancer-related deaths (Ptrend = 0.021 in model 1; 0.013 in model 2). HbA1c level and colorectal, stomach, and lung cancer mortality exhibited a positive relationship, whereas liver cancer-related mortality showed an inverse relationship with HbA1c level (Ptrend = 0.001). Conclusions: Our study showed that abnormal glucose metabolism is significantly associated with cancer-related mortality, and its relationship varies with each type of cancer.

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“…Rising HbA1c and increasing age were associated with increased cancer mortality (28). We now have moderate-certainty evidence that periodontal treatment using subgingival instrumentation significantly improves glycemic control in people with both periodontitis and DM compared to no treatment or usual care (29). The study findings support the Mediterranean dietary model as a suitable model for T2DM and the concept that the beneficial health effects of the Mediterranean diet lie primarily in the synergy among various nutrients and foods rather than on any individual component (30).…”

Section: Discussionmentioning

confidence: 99%