Association Between Obesity and Sarcoidosis: A Systematic Review and Meta-analysis

Wambui, David; Ndili, Ogugua; Kearney, Gregory D.

doi:10.11648/j.ajim.20200805.18

Cited by 1 publication

(2 citation statements)

References 67 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found an increased risk of sarcoidosis with obesity (BMI ≥30.0 kg·m −2 ) and abdominal obesity measured using waist circumference. In the Black Women's Health Study and the Nurses’ Health Study, a 42% to 74% increased sarcoidosis risk was observed with BMI ≥30.0 kg m −2 , which is in line with our results [ 3 ]. Adipose tissue is a metabolically active endocrine organ that secretes a variety of proinflammatory adipokines that induce a chronic inflammatory state in obese individuals, which may play a role in sarcoidosis aetiopathogenesis [ 34 ].…”

Section: Discussionsupporting

confidence: 92%

“…Several recent studies, mostly in women [ 3 ], have shown that obesity is associated with a higher sarcoidosis risk, but there is little data on the association between obesity and sarcoidosis in men. Previous studies have measured body mass index (BMI) via self-reported height and weight, but none of them have investigated waist circumference.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modifiable lifestyle risk factors for sarcoidosis: a nested case–control study

et al. 2023

View full text Add to dashboard Cite

We aimed to investigate whether obesity, tobacco use, alcohol consumption, and physical inactivity are associated with sarcoidosis risk. We conducted a matched case-control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identifiedviamedical records and matched to controls (n=660) on sub-cohort, sex, birth, and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95%CI). Compared with never smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95%CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95%CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34 (95%CI 0.94–1.92) but not with overweight (aOR 0.99; 95%CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds (aOR 1.25; 95%CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95%CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%