Association between Ocular Pseudoexfoliation and Sensorineural Hearing Loss

Singham, Nandini Vijaya; Zahari, Mimiwati; Peyman, Mohammadreza; Prepageran, Narayanan; Subrayan, Visvaraja

doi:10.1155/2014/825936

Cited by 18 publications

(21 citation statements)

References 12 publications

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“…; Singham et al. ). It has been suggested that in XFS, the cochlea might be affected through exfoliation microfibrillar deposits that lead to dysfunction of the mechanoreceptors in the inner ear (organ of Corti) and thus impact on hearing (Cahill et al.…”

Section: Introductionmentioning

confidence: 99%

Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open‐angle glaucoma

Tryggvason

Jónasson

Cotch

et al. 2015

Acta Ophthalmologica

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Purpose To determine if adults, aged 66–96 years, with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), or primary open-angle glaucoma (POAG) have poorer hearing than controls of similar age. Methods Case (XFS/XFG and POAG) and control status were diagnosed in the Reykjavik Glaucoma Studies (RGS) using slit-lamp examination, visual field testing, and optic disc photographs; the RGS data were merged with the Age, Gene/Environment Susceptibility–Reykjavik Study (AGES-R) that collected hearing data using air-conduction, pure-tone thresholds obtained at 0.5, 1, 2, 3, 4, 6 and 8 kHz categorized by better ear (BE) and worse ear (WE), based on pure-tone averages (PTAs) calculated separately for low and middle frequencies (PTA512 – mean of thresholds at 0.5, 1, and 2 kHz) and high frequencies (PTA3468 – mean of thresholds at 3, 4, 6 and 8 kHz). Multivariable linear regression was used to test for differences in PTAs between cases and controls. Results The mean age for 158 XFS/XFG cases (30.4% male) was 77.4 years, 95 POAG cases (35.8% male) was 77.9 years, and 123 controls (46.3% male) was 76.8 years. Using multivariable linear regression analysis there were no consistent, statistically significant differences in PTAs between the two case groups and controls in either the low or high frequency range, even when stratified by age group. Conclusion Among the older individuals examined in this study, hearing loss is highly prevalent and strongly associated with male gender and increasing age. Since we did not find consistent statistically significant difference in hearing between cases and controls, the diagnosis of XFS/XFG or POAG does not as such routinely call for audiological evaluation.

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Section: Introductionmentioning

confidence: 99%

Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open‐angle glaucoma

Tryggvason

Jónasson

Cotch

et al. 2015

Acta Ophthalmologica

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“…Literature review of positive risk factors for XFS in general [Tables 5 - 7 ][ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 ] and XFS in young subjects [ Table 8 ][ 82 83 84 85 86 87 88 89 90 91 …”

Section: Resultsmentioning

confidence: 99%

A Case–Cohort Study of Exfoliation Risk Factors and Literature Review

Mansour

Konstas

Mansour

et al. 2021

Middle East African Journal of Ophthalmology

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The purpose of the study is to evaluate the risk factors associated with exfoliation in a case-cohort setting and literature review. This single-center, prospective, case-cohort study was carried out from January 2010 to April 2020 on patients operated for cataract surgery by a single surgeon in Lebanon. Forty-nine consecutive patients with exfoliation syndrome (XFS) and 62 consecutive control patients were identified and further investigated for selected systemic (diabetes mellitus, systemic hypertension, asthma, or atopy) and ocular variables (baseline vision, severity of nuclear sclerosis, glaucoma, eye rubbing, history of dry eye, or allergic eye disease). The mean baseline Snellen visual acuity was 20/283 in XFS versus 20/145 in control cases ( P = 0.012). XFS also demonstrated significantly denser nuclear sclerosis than controls ( P = 0.00958). By univariate analysis, allergic conjunctivitis (15 [30.6%] vs. 2 [3.2%]; P < 0.001), dry eye (20 [40.8%] vs. 13 [21.0%]; P = 0.0133), and habitual rubbing of the eyes (33 [67.3%] vs. 19 [30.6%]; P < 0.001) were associated with the presence of XFS. Habitual ocular rubbing was closely associated with allergic conjunctivitis (odds ratio [OR] = 13.0; 95% confidence interval [CI]: 2.8–58.8; P = 0.032). After multivariable analysis, the following variables showed significant results: glaucoma (OR = 34.5; 95% CI: 4.4–250; P = 0.010), duration of surgery (OR = 5.6; 95% CI 2.43–12.9; P < 0.001), and habitual ocular rubbing (OR = 4.42; 95% CI: 1.97–9.90; P = 0.029). This study shows a novel potential correlation between eye rubbing and XFS in a Lebanese cohort. Chronic eye rubbing induces or may exacerbate preexistent zonular damage in subjects with XFS, hence the need to better manage concurrent ocular surface disorder in these patients.

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“…Researchers have noted the association between PEX and some neurological diseases. Singham et al suggested that the accumulation of pseudoexfoliation material in sensorineural cells could explain the association between PEX and hearing loss [26]. Zojaji et al also showed a strong association between PEX and sensorineural hearing loss [27].…”

Section: Discussionmentioning

confidence: 99%

Electrodiagnostic Signs of Carpal Tunnel Syndrome in Ocular Pseudoexfoliation Syndrome: A Case-Control Study

Shahriari

Karimzadeh

Esmaily

et al. 2021

Preprint

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Purpose To assess the occurrence and severity of electrodiagnostic signs of carpal tunnel syndrome (ED-CTS) in patients with ocular pseudoexfoliation (PEX) and compare them with normal subjects.Method A 1:1 case-control study was designed and 60 patients with PEX were recruited from May 2019 to February 2021, and the findings were compared with 59 age- and gender-matched healthy controls. All patients underwent complete ophthalmologic examination and nerve conduction velocity test at the median nerve was used to assess the occurrence and severity of ED-CTS in both hands.Results The mean age of participants was 59.8 ± 4.5 years. Occurrence of ED-CTS was 38.3% in PEX patients and 20.3% in control subjects (P = 0.025). There was also a significant difference in the severity, and presence of asymptomatic CTS (P < 0.05). Adjusting other variables, including; age, sex and job difficulty, having severe ED-CTS showed a 3.49-fold higher chance in the PEX group (P = 0.002). Conclusion There is a direct relation between PEX and the occurrence, as well as severity of ED-CTS.

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Association between Ocular Pseudoexfoliation and Sensorineural Hearing Loss

Cited by 18 publications

References 12 publications

Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open‐angle glaucoma

Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open‐angle glaucoma

A Case–Cohort Study of Exfoliation Risk Factors and Literature Review

Electrodiagnostic Signs of Carpal Tunnel Syndrome in Ocular Pseudoexfoliation Syndrome: A Case-Control Study

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