Association between overweight/obesity and clinical activity in rheumatoid arthritis

Álvarez-Nemegyei, José; Pacheco‐Pantoja, Elda; González-Salazar, Melina; López-Villanueva, Ricardo F.; May-Kim, Sherlin; Martínez-Vargas, Liliane; Quintal-Gutiérrez, Daniel

doi:10.1016/j.reumae.2018.11.014

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…The subject of obesity as a determinant of QoL, which in our study turned out to have a negative effect in the regression analysis, is associated with the increasing problem of disability, pain, and the number of affected joints. 38 There are studies which show that obesity in RA patients is associated with chronic inflammation, immune response, and chronic deficiency of vitamin D. In their study, Liu et al concluded that obesity reduces the chances of remission in RA and negatively affects disease activity and treatment outcomes reported by patients. 39 It needs to be emphasised that the knowledge about the association between obesity and RA is incomplete and requires continuous research.…”

Section: Discussionmentioning

confidence: 99%

“…36–38 Accordingly, in the case of RA, longer disease duration may be associated with greater disheartenment with life and long-term treatment, fatigue related to frequent visits to medical facilities or increasing disability in the course of progressive inflammation, 36 which in turn results in even greater mental health problems in the area of stress, depression, and discouragement. 37 , 38 …”

Section: Discussionmentioning

confidence: 99%

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Quality of Life and Depression in Rheumatoid Arthritis Patients Treated with Biologics – A Single Centre Experience

Tański¹,

Szalonka²,

Tomasiewicz³

2022

PRBM

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Introduction Patients with rheumatoid arthritis (RA) often experience depression, which has a very negative impact on the assessment of the quality of life (QoL). However, there are not many studies that assess the relationship between depression and QoL in RA patients. The aim of the study was to assess the level of QoL and determine the mutual relationship between anxiety and depression levels and QoL in patients treated for RA. Material and Methods The study included 101 patients (aged:52.4±16.97), who met the established criteria for a diagnosis of RA and treatment with a biological agent. Only standardized tools were used to examine the patients: WHO-QoL, HADS and the VAS scale. Results The mean RA duration in the group studied was 13.54±9.51 years and the disease activity score was 4.8±0.8. The mean QoL perception score was 3.48± 0.8. Nearly 40% of the respondents could not clearly determine their QoL, perceiving it as neither poor nor good, and 10% believed their QoL is poor or very poor. The correlation analysis revealed that anxiety is significantly and negatively associated with QoL in the psychological domain (r = −0.472, p < 0.001) and social domain (r = −0.298, p = 0.023) and depression is significantly and negatively associated with QoL in the psychological domain (r = −0.322, p = 0.01) and physical health domain (r = −0.209, p = 0.04). In the multiple linear regression model, depression was an independent negative predictor affecting the following domains: perception of QoL and perception of health, and physical health. Conclusion RA patients treated with biologics present a low level of health perception and an average level of QoL perception. Depression and anxiety negatively correlate with QoL domains: the higher the anxiety and depression levels, the poorer the QoL in the psychological and social relationships domains. Depression is an independent determinant of decreased QoL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality of Life and Depression in Rheumatoid Arthritis Patients Treated with Biologics – A Single Centre Experience

Tański¹,

Szalonka²,

Tomasiewicz³

2022

PRBM

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“…Notably, weight overloading, uneven weight loading, or uneven distribution of weight are comon causes of arthritis during later stages of life. 4,5 For example, in my kung-fu class, my teacher asked me to hold the split stance: one foot forward and one foot back while moving a stick in one hand. While performing this movement, I felt pain in my hand and lower back.…”

Section: General Reasons For Body Achesmentioning

confidence: 99%

Hand and back muscle pain and how to avoid them: A regulatory writer's story

Xu¹

2022

Med Writ

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“…Most measures of body fats mass were found to be positively correlated with the degree to which joints were swollen. Routine treatment for RA patients must involve assessing and working to enhance body composition (8) , therefore, this study was aimed to explain about correlation between BMI and rheumatoid factor (RF)…”

Section: Introductionmentioning

confidence: 99%

The Correlation Study between Rheumatoid Arthritis and Obesity in Babylon Province

Mahdi¹,

Hussein²,

Dabbi³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: The prevalence of obesity has risen dramatically in recent years. History of obesity is a significant risk factor for the development of rheumatoid arthritis (RA).Objective: This study aimed to survy about obesity as a major threat for public health and attachment with other disease such as RA, and because several research refer to association to each other in differnet patients around the world. Subjects and Methods: It included 64 serum samples, classified as 16 from obese patients, 16 from rheumatoid patients, 16 from patients with both rheumatoid arthritis and obesity, and 16 from healthy individuals. All of these were recruited between October 2021 and August 2022, from different government hospital laboratory and private labs in Babylon City. Results:The results revealed significant differences (P>0.05) between control group and group of patients who had rheumatoid and obesity regarding the level of rheumatoid factor (RF), also showed positive correlation between body mass BMI and rheumatoid factor in the group of patients who had rheumatoid and obesity, but it revealed negative correlation between body mass index and rheumatoid factor in the group of patients who had obesity. Conclusion: Rehumatoid factor (RF) doesn't make important role in the obesity, and there is no association between rehumatoid arthritis and body mass index.

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Association between overweight/obesity and clinical activity in rheumatoid arthritis

Cited by 10 publications

References 18 publications

Quality of Life and Depression in Rheumatoid Arthritis Patients Treated with Biologics – A Single Centre Experience

Quality of Life and Depression in Rheumatoid Arthritis Patients Treated with Biologics – A Single Centre Experience

Hand and back muscle pain and how to avoid them: A regulatory writer's story

The Correlation Study between Rheumatoid Arthritis and Obesity in Babylon Province

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