Association between ovine Toll-like receptor 4 (<i>TLR4)</i> gene coding variants and presence of <i>Eimeria</i> spp. in naturally infected adult Turkish native sheep

Yaman, Yalçın; Aymaz, Ramazan; Keleş, Murat; Bay, Veysel; Özüiçli, Mehmet; Şenlik, Bayram

doi:10.1080/10495398.2020.1824921

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…Genes that potentially affect immune responses are associated with metabolism, mitochondrial function, longevity, heat shock responses, and other physiological responses [97]. Several studies have been conducted to identify QTLs for GIP resistance in ruminants (Table-4) [2,11,[97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115]. The mechanisms underlying GIP resistance have been studied [53].…”

Section: Genetic Markers Of Gip Resistancementioning

confidence: 99%

“…The host relies almost entirely on T lymphocytes, in particular, T helper 2 (Th2) cells to eliminate GIPs during infection, which triggers the development of the specific cytokines The difference in the hinge segment of IgHA can render the molecule more or less versatile and thus more or less capable of binding antigens with a number of epitope separations of any particular pathogen [111,112] TLRs (TLR-2, TLR-4 and TLR-9) Following GIPs infection, the TLR genes are rather commonly displayed in the intestinal mucosa of genetically resistant animals [113,114] The CLRs The CLRs genes are responsible for the natural identification of carbohydrate surface found on the GIPs. The mannose receptor to bind to Trichuris muris's excretory/secretory [115] GIPs=Gastrointestinal parasites, MHC=Major histo-compatibility complex, FEC=Fecal egg count, IFN-γ=Interferon gamma, IgHA=Immunoglobulin heavy chain, IL=Interleukin, CLR=C-type lectin receptors, TLR=Toll-like receptors Available at www.veterinaryworld.org/Vol.15/October-2022/10.pdf responsiveness, and reproductive success [118].…”

Section: Mhc Class II Locus Drb1mentioning

confidence: 99%

“…The germline-encoded PRRs, including the C-type lectin receptors (CLRs) [115] and toll-like receptors (TLRs) [114], NOD-like receptors, and RIG I-like receptors, are some of the first pathogen detection systems. The PRR proteins identify damage-associated molecular patterns and pathogen-associated molecular Available at www.veterinaryworld.org/Vol.15/October-2022/10.pdf patterns.…”

Section: Pattern Recognition Receptors (Prrs)mentioning

confidence: 99%

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Prevalence and resistance to gastrointestinal parasites in goats: A review

2022

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Gastrointestinal parasitism, particularly nematode infection, is a major health issue affecting goats worldwide, resulting in clinical diseases and productivity loss. Prevalent gastrointestinal parasites (GIPs) affecting goats in South Africa are the Strongyloides papillosus, Eimeria spp., and Strongyles, especially the Haemonchus contortus and Trichostrongylus spp. According to the issues discussed in this paper and by other authors, the prevalence and intensity of various GIPs vary with an animal's location, breed, age, sex, and season. Because GIPs easily develop resistance to chemical treatment, selecting and breeding genetically GIP-resistant animals would be a relatively simple and inexpensive strategy for reducing or eliminating the current reliance on chemotherapy. Potential phenotypic indicators for selecting GIP-resistant goats include parasitological, immunological, and pathological phenotypic markers. Synergistic use of these indicators should be encouraged for a more accurate simplified genotype selection of resistant animals. Genes with Mendelian inheritance, particularly those involved in immunoregulatory mechanisms, have been identified in goats. Exploring this knowledge base to develop cost-effective molecular tools that facilitate enhanced genetic improvement programs is a current challenge. Future statistical and biological models should investigate genetic variations within genomic regions and different candidate genes involved in immunoregulatory mechanisms, as well as the identification of single nucleotide polymorphisms known to affect GIP infection levels.

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Section: Genetic Markers Of Gip Resistancementioning

confidence: 99%

Section: Mhc Class II Locus Drb1mentioning

confidence: 99%

Section: Pattern Recognition Receptors (Prrs)mentioning

confidence: 99%

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Prevalence and resistance to gastrointestinal parasites in goats: A review

2022

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“…For instance, an Australian study deciphering sheep variance in fecal egg counts employing the GWAS methodology with 600,000 SNPs determined that the QTL explaining the high variance was located within chromosome 2 [ 18 ]. Furthermore, in a study conducted on Turkish native breeds, namely Karacabey Merino, Kıvırcık, İmroz (Gökçeada), Chios, Cine Çapari, and Karakaçan sheep, a total of 14 variants within the TLR4 gene were found associated with coccidian oocyst count [ 33 ]. Search for prior studies associating Tapeworm ( Moniezia spp. )…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis of Gastrointestinal Parasite Resistance in Akkaraman Sheep

Arzık

Kızılaslan

White

et al. 2022

Genes

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Genome-wide association studies (GWAS) have been used as an effective tool to understand the genetics of complex traits such as gastrointestinal parasite (GIP) resistance. The aim of this study was to understand the genetics of gastrointestinal parasite (nematodes, Moniezia spp., Eimeria spp.) resistance in Akkaraman sheep by performing genomic heritability estimations and conducting GWAS to uncover responsible genomic regions. This is one of the first studies to examine the genetic resistance of Akkaraman sheep to the tapeworm parasite. The samples from 475 animals were genotyped using the Axiom 50K Ovine Genotyping Array. Genomic heritability estimates ranged from 0.00 to 0.34 for parasite resistance traits. This indicates that measured phenotypes have low to moderate heritability estimates. A total of two genome-wide significant SNP associated with TNEM3 and ATRNL1 genes and 10 chromosome-wide significant SNPs related with 10 genes namely NELL1, ST6GALNAC3, HIPK1, SYT1, ALK, ZNF596, TMCO5A, PTH2R, LARGE1, and SCG2 were suggested as candidates for parasite resistance traits. The majority of these candidate genes were involved in several basic biological processes that are essential and important for immune system functions and cellular growth; specifically, inflammatory responses, cellular transport, cell apoptosis, cell differentiation, histone de-acetylation, and endocytosis. These results have implications for animal breeding program studies due to the effect that the genetic background has on parasite resistance, which underlies many productive, health, and wellness-related traits.

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Association between ovine Toll-like receptor 4 (TLR4) gene coding variants and presence of Eimeria spp. in naturally infected adult Turkish native sheep

Cited by 2 publications

References 31 publications

Prevalence and resistance to gastrointestinal parasites in goats: A review

Prevalence and resistance to gastrointestinal parasites in goats: A review

Genomic Analysis of Gastrointestinal Parasite Resistance in Akkaraman Sheep

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