Association between pain, anxiety, and alpha2 frontal activity in women with fibromyalgia

Abstract

Fibromyalgia is a disorder of the central nervous system, with the presence of chronic generalized pain, fatigue, morning stiffness, anxiety and depression symptoms. Higher amplitudes of the frequency band alpha2 have been associated with higher relaxation in this population. In the present study, we analysed the association between pain, anxiety, and the spectral power of alpha2 frontal in women with fibromyalgia. Thirty-one women diagnosed with fibromyalgia, for at least three months, took part in the study. Results revealed a statistically significant positive relationship between pain and anxiety levels. However, we found no association between the spectral power of alpha2 in the frontal cortex and the measures between anxiety and pain in the patients. Present findings emphasize the importance of understanding the cortical activity and the central control mechanisms in fibromyalgia.

Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review

“…Finally, 76 studies were included. 1 , 5 – 8 , 10 , 11 , 15 , 16 , 18 – 27 , 30 – 33 , 35 , 37 – 49 , 51 , 56 , 59 , 60 , 63 , 66 – 69 , 74 – 76 , 79 , 80 , 82 , 89 – 91 , 95 – 98 , 100 – 105 , 109 , 110 , 112 – 115 , 120 , 122 , 124 – 126 Figure 1 depicts the PRISMA flow diagram of study selection along with reasons for study exclusion at every stage.…”

“…Finally, 76 studies were included. 1,[5][6][7][8]10,11,15,16,[18][19][20][21][22][23][24][25][26][27][30][31][32][33]35,[37][38][39][40][41][42][43][44][45][46][47][48][49]51,56,59,60,63,[66][67][68][69][74][75][76]79,80,82,[89]…”

“…However, because included studies used heterogeneous statistical methods for hypothesis testing, we did not superimpose effect size estimation contours on the plots. Modified albatross plots were used for comparison of PAF, frequency-specific power, and frequency-specific connectivity at theta (4-8 Hz), alpha (8)(9)(10)(11)(12)(13), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and gamma frequencies in cross-sectional (diagnostic biomarker), longitudinal (monitoring biomarker), and descriptive studies (monitoring/diagnostic biomarker). For graphical presentation of longitudinal study results, we only included studies that reported pain relief.…”