BackgroundWith the increase in revision total hip arthroplasty (THA) cases, understanding its causes is essential for a surgeons' clinical decision-making. Studies have reported on revision THA epidemiology in developed countries; however, its epidemiology in China remains unclear. We reviewed revision THA causes in a tertiary center in China. MethodsWe retrospectively identified 1,353 revision THAs at our institution from January 1999 to December 2018 (20 years). The causes for revision THA were compared among patients who were grouped based on the time of revision surgery, age at revision, and number of revisions, using the Student's t-test. ResultsAseptic loosening (826 hips, 61.0%) and infection (151 hips, 11.2%) were the most common reasons for revision THA. Compared with the number of cases from January 1999 to December 2008, the number of cases from January 2009 to December 2018 increased 2.4-fold; the proportion of revisions due to aseptic loosening, periprosthetic fracture, instability, and osteolysis increased, and infection rate decreased. The infection rate was higher among patients aged over 60 years, whereas the incidence rate of aseptic loosening, periprosthetic fracture, and instability was higher among those aged 60 years or less. Infections (52.8%) were more common than aseptic loosening (37.4%) in second or subsequent revisions.ConclusionAseptic loosening and infection remain the most common causes of revision THAs at our center. Although the proportion of infections has decreased in the recent decade, a national database is necessary for a more comprehensive understanding of the causes of revision THAs in China. This work provides an understanding and comparison of the causes of revision THA in an orthopedic center among the Chinese population. This may reveal a potential change in revision THAs causes in the future, reminding surgeons to find a proper way to treat them.