Association between PDCD1 gene polymorphisms and psoriasis susceptibility in the Chinese population

Hua, Shan; Fan, Bin; Mao, Weiwei; Xu, Rong; Wang, Yifei; Kuai, Le; Ding, Xiaojie; Li, Bin; Chen, Jie; Miao, Xiao

doi:10.1111/ijd.15665

Cited by 5 publications

(7 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in two other separate case-control studies, no associations were detected between PD-1.6 polymorphism and the risk of developing CRC in subjects from Heilongjiang Province in Northeast China [ 2 ] and Eastern China [ 36 ]. However, associations between PD-1.6 polymorphisms and several infectious and autoimmune diseases have been reported in many studies [ 20 , 27 , 29 , 30 , 32 , 55 , 56 ]. For PD-1.5 and PD-1.9 , controversial results have been reported for their association with cancer diseases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Alharbi

Vaali-Mohammed²,

Alomar³

et al. 2022

Medicina

View full text Add to dashboard Cite

Checkpoint programmed death-1 (PD-1) has been identified as an immunosuppressive molecule implicated in the immune evasion of transformed cells. It is highly expressed in tumor cells in order to evade host immunosurveillance. In this study, we aimed to assess the association between single nucleotide polymorphisms (SNP) of PD-1 and the risk of colorectal cancer (CRC) in the Saudi population. For this case-control study, the TaqMan assay method was used for genotyping three SNPs in the PD-1 gene in 100 CRC patients and 100 healthy controls. Associations were estimated using odds ratios (ORs) and 95% confidence intervals (95% CIs) for multiple inheritance models (codominant, dominant, recessive, over-dominant, and log-additive). Moreover, PD-1 gene expression levels were evaluated using quantitative real-time PCR in colon cancer tissue and adjacent colon tissues. We found that the PD-1 rs10204525 A allele was associated with an increased risk of developing CRC (OR = 2.35; p = 0.00657). In addition, the PD-1 rs10204525 AA homozygote genotype was associated with a high risk of developing CRC in the codominant (OR = 21.65; p = 0.0014), recessive (OR = 10.97; p = 0.0015), and additive (OR = 1.98; p = 0.012) models. A weak protective effect was found for the rs2227981 GG genotype (OR = 2.52; p = 0.034), and no significant association was found between the rs2227982 and CRC. Haplotype analysis showed that the rs10204525, rs2227981, rs2227982 A-A-G haplotype was associated with a significantly increased risk of CRC (OR = 6.79; p =0.031).

show abstract

Section: Discussionmentioning

confidence: 99%

“…Variations such as SNPs could influence the gene at the transcriptional level. Several types of cancers and immune diseases have been linked to genetic polymorphisms in the PD-1 and PD-L1 genes [ 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Alharbi

Vaali-Mohammed²,

Alomar³

et al. 2022

Medicina

View full text Add to dashboard Cite

show abstract

“…The MMP-9 rs3918242 polymorphism was evaluated in 14 studies with a total of 4733 subjects (2287 cases and 2446 controls) [ 11 , 13 – 17 , 19 , 20 , 22 , 23 , 25 , 29 , 30 , 32 ]. Genotypes in each of these studies were in HWE.…”

Section: Resultsmentioning

confidence: 99%

“…The MMP-9 rs3918242 polymorphism is a common cytosine-to-thymidine mutation at position -1562 within the MMP-9 gene promoter [ 11 ]. Previous studies have shown that the T allele of this SNP was associated with increased promoter activity and higher MMP-9 levels [ 14 , 23 ]. Given the prominent role of MMP-9 in COPD pathogenesis, dysregulation of MMP-9 expression induced by this SNP may increase the risk of COPD in genotypes containing the T allele.…”

Section: Discussionmentioning

confidence: 99%

Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis

et al. 2021

View full text Add to dashboard Cite

IntroductionGiven evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between genetic polymorphisms in MMP genes and COPD risk. However, reliable measures of these results are lacking.Material and methodsWe assessed the published evidence for association of the MMP-3, MMP-9 and MMP-12 polymorphisms with COPD risk using meta-analytic techniques. Odds ratio (OR) and 95% confidence intervals (CI) were calculated for each study using fixed or random effect models.ResultsA total of 23 case-control studies were included in the meta-analysis. No significant association was observed between the MMP-9 rs3918242 polymorphism and COPD risk in the overall populations under the dominant (T/T + C/T vs C/C: OR=1.30, 95% CI: 1.00-1.69, P=0.054) and allele contrast (T allele vs C allele: OR=1.22, 95% CI: 0.97-1.53, P=0.088) models. However in sub-group analysis the polymorphism rs3918242 was significant in Asians under the dominant model (T/T + C/T vs C/C: OR=1.66, 95% CI: 1.02-2.72, P=0.043). The results for MMP-12 rs2276109 showed an association with COPD only in mixed populations (G/G + A/G vs A/A: OR=1.57, 95% CI: 1.10-2.24, P=0.013; G allele vs A allele: OR=1.52, 95% CI: 1.09-2.14, P=0.015). We did not find any significant association of the MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD.ConclusionsThe findings in this meta-analysis suggest that the risk of COPD is associated with the MMP-9 rs3918242 and MMP-12 rs2276109 polymorphisms in certain ethnic groups.

show abstract

“… 110 The G allele of PD1.6 increased the risk of psoriasis in the Chinese subjects. 111 The frequency of the rs2787094 C allele of ADAM33 gene was significantly linked with psoriasis in a Han population. 112 The HCP5 gene 335 T> G polymorphism was associated with the increased risk of developing psoriasis in the Indian patients.…”

Section: The Other Genesmentioning

confidence: 96%

Psoriasis: An Immunogenetic Perspective

Kocaaga

2022

Glob Med Genet

View full text Add to dashboard Cite

Psoriasis is an erythematous-squamous dermatosis with a polygenic inheritance history. Both environmental and genetic factors play a role in the etiology of the disease. Over the past two decades, numerous linkage analyzes and genome-wide association studies have been conducted to investigate the role of genetic variation in disease pathogenesis and progression. To date, >70 psoriasis susceptibility loci have been identified, including HLA-Cw6, IL12B, IL23R, and LCE3B/3C. Some genetic markers are used in clinical diagnosis, prognosis, treatment, and personalized new drug development that can further explain the pathogenesis of psoriasis. This review summarizes the immunological mechanisms involved in the etiopathogenesis of psoriasis and recent advances in susceptibility genes and highlights new potential targets for therapeutic intervention.

show abstract

Association between PDCD1 gene polymorphisms and psoriasis susceptibility in the Chinese population

Cited by 5 publications

References 24 publications

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis

Psoriasis: An Immunogenetic Perspective

Contact Info

Product

Resources

About