Association between peptidyl arginine deiminase 4 (PADI4)-104C/T polymorphism and rheumatoid arthritis: a meta-analysis in the Chinese population

Abstract

ABSTRACT. The correlation between the -104C/T polymorphism in the peptidyl arginine deiminase 4 (PADI4) gene and rheumatoid arthritis (RA) risk has been analyzed in several studies. However, the results are inconclusive and remain to be confirmed in several ethnic groups. The effect of the PADI4-104C/T polymorphism on RA risk in the Chinese population was evaluated in a meta-analysis. Studies with dates of publication up to July 2015 conforming to the inclusion criteria were retrieved from PubMed and Chinese databases. The associations were assessed with pooled odds ratios (ORs) and 95% confidence intervals (CIs). Ten studies, including 2119 RA cases and 1962 controls, that conformed to the study criteria were included in this analysis. The overall analysis indicated a significant association between the PADI4- 30-2.37). Analysis of data stratified by the geographic area and source of controls revealed that the PADI4-104C/T polymorphism was significantly associated with RA risk in a North Chinese population. In conclusion, the results of this meta-analysis indicated that the PADI4-104C/T variants could influence the risk of RA in the Chinese population; further studies in other ethnic groups are required to draw definite conclusions.

Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population

“…Of the 10 potentially relevant articles (9–18) identified for full study retrieval, two (9,10) were excluded due to repeated studies. Finally, 8 case-control studies (11–18) met the inclusion criteria (Figure 1). The publication year of involved studies ranged from 2007 to 2012.…”

Peptidylarginine deiminase 4 -104C/T polymorphism and risk of rheumatoid arthritis: A pooled analysis based on different populations

“…Although many studies have been conducted to elucidate the relationship between PADI4 -104C/T polymorphism and RA risk, a definite conclusion has not been drawn. So far, several meta-analyses have been published regarding the relationship between PADI4 -104C/T polymorphism and RA risk [ 21 – 25 ]. Nevertheless, their results were inconclusive and inconsistent.…”

“…For example, one meta-analysis reported that there was significant association between PADI4 -104C/T polymorphism and RA risk in both an Asian and European population [ 21 ], whereas two meta-analyses found significant association only in Asian individuals [ 23 , 24 ]. Furthermore, the meta-analysis performed by Yang et al [ 22 ] showed that the pooled estimates for PADI4 -104C/T polymorphism were not statistically significantly associated with RA; only one meta-analysis was conducted in a separate ethnic group [ 25 ]. Therefore, we conducted this updated meta-analysis to assess the relationship between PADI -104C/T polymorphism and RA risk in different populations.…”

“…Because we found only one study from Spain, Hungary, and Iran, respectively [ 18 – 20 ], we do not discuss the association between PADI -104C/T and RA among these populations in the current meta-analysis. In comparison with previous meta-analyses [ 21 – 25 ], the current study involved more research in multiethnic groups. Furthermore, the effects of gene-environment interactions on RA risk were also evaluated in each separate ethnic group.…”

The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases

“…In addition, the study discovered an association between the presence of anti-PAD4 antibodies and a haplotype composed of three single nucleotide polymorphisms with an odds ratio of 2.59 [ 52 ]. Alternatively, another polymorphism (PAD4 104C/T) was reported as an RA risk factor in a Chinese study [ 53 ]. Martinez-Prat et al [ 54 ] measured antibodies against PAD3 and PAD4 in RA patients.…”