Association between per and polyfluoroalkyl substances and markers of inflammation and oxidative stress

Omoike, Ogbebor Enaholo; Pack, Robert P.; Mamudu, Hadii M.; Liu, Ying; Strasser, Sheryl; Zheng, Shimin; Okoro, Joy; Wang, Liang

doi:10.1016/j.envres.2020.110361

Cited by 98 publications

(44 citation statements)

References 38 publications

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“…In this prior work, the relationship between PFNA and CRH was stronger among women who experienced stress, indicating a joint effect of chemical and non-chemical stressors on CRH ( Eick et al, 2022 ). Other pathways may be through inflammation, as studies have linked depression to elevated maternal biomarkers of inflammation and recent work suggests that PFAS are also associated with chronic inflammation ( Omoike et al, 2021 ; Lahti-Pulkkinen et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors

Eick

Enright

Padula

et al. 2022

Environment International

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Section: Discussionmentioning

confidence: 99%

Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors

Eick

Enright

Padula

et al. 2022

Environment International

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“… 15 , 16 In addition, FAS exposure is associated with increased inflammatory markers and oxidative stress. 14 , 36 Given the systemic effects which can be induced by both oxidative stress and PPARα dysregulation, the combination of these two molecular actors may in part explain the broad health effects observed in association with PFAS exposure.…”

Section: Discussionmentioning

confidence: 99%

Associations between PFAS occurrence and multimorbidity as observed in an electronic health record cohort

Ward‐Caviness¹,

Moyer²,

Weaver³

et al. 2022

Environmental Epidemiology

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Background: Per and polyfluoroalkyl substances (PFAS) are associated with health outcomes ranging from cancer to high cholesterol. However, there has been little examination of how PFAS exposure might impact the development of multiple chronic diseases, known as multimorbidity. Here, we associated the presence of one or more PFAS in water systems serving the zip code of residence with chronic disease and multimorbidity. Methods: We used data from the unregulated contaminant monitoring rule 3 to estimate exposure to PFAS for a random sample of 10,168 patients from the University of North Carolina Healthcare System. The presence of 16 chronic diseases was determined via. their electronic health records. We used a logistic regression model in a cross-sectional study design to associate the presence of one or more PFAS with multimorbidity. Models were adjusted for age, race, sex, smoking status, socioeconomic status, and 20 county-level confounders. Results: There were four PFAS found in water systems that served at least one zip code represented in our patient data: PFOA, PFHpA, PFOS, and PFHxS. Exposure to any PFAS was associated with a odds ratio of 1.25 for multimorbidity (95% confidence interval = 1.09, 1.45). Among the chronic diseases with at least 300 cases, we observed associations with dyslipidemia, hypertension, ischemic heart disease, and osteoporosis. Conclusion: Exposure to PFAS is associated with a range of chronic diseases as well as multimorbidity. Accounting for the joint impacts of PFAS on multiple chronic conditions may give an increasingly clear picture of the public health impacts of PFAS.

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“…Overall, MetS is a cluster of interrelated risk factors (obesity, insulin resistance, dyslipidemia, and hypertension) all known as risk factors of cardiovascular diseases (CVD), therefore different mode of action/adverse outcome pathways (AOPs) of PFAS could influence the final results [14,43]. For instance, the PFAS-to-lipid associations are explained in animal studies by transactivation of peroxisome proliferator-activated receptor α (PPARα) contributing to a liver metabolic pathway which plays an important role in the regulation of cholesterol and triglyceride levels; or oxidative stress has been proposed to be a key player in the pathogenesis of hypertension [44][45][46][47]. Other putative molecular initiating/key events for PFAS might be explained by mitochondrial dysfunction, interference of protein binding, partitioning into lipid bilayers (enterohepatic cycling of both bile acids and PFAS), altered calcium homeostasis, and inappropriate activation of molecular signals controlling cell functions [14,48].…”

Section: Discussionmentioning

confidence: 99%

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Jeddi

Zuanna

Barbieri

et al. 2021

IJERPH

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Background: Studies on the association between perfluoroalkyl substances (PFAS) and metabolic syndrome (MetS) are limited, and results are inconsistent. We aimed to examine the associations between PFAS serum levels and the prevalence of MetS among highly exposed young adults (ages 20–39) residents of a large area of the Veneto Region (North-Eastern Italy) primarily stemming from PFAS water contamination before September 2013. A total of 15,876 eligible young adult residents living in the investigated municipalities were enrolled in the study from January 2017 to July 2019. Methods: MetS was defined by using a modified harmonized definition requiring the presence of 3 of the following: obesity (body mass index ≥30), elevated triglyceride (TG), reduced high-density lipoprotein cholesterol, elevated blood pressure, and hemoglobin A1c ≥ 6.1% or self-reported diabetes mellitus or drug treatment for hyperglycemia. Multivariable generalized additive models were performed to identify the associations between four serum PFAS, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), and risk of MetS controlling for potential confounders. Results: A total of 1282 participants (8.1%) met the criteria of MetS with a higher prevalence among men. PFOA, PFHxS, and PFNA were not associated with the risk of MetS, whereas PFOS showed a consistent protective effect against the risk of MetS (OR 0.76, (95% CI: 0.69, 0.85) per ln-PFOS). However, we found statistically significant positive associations between PFAS serum levels and individual components of MetS, mainly elevated blood pressure and elevated TG. Conclusion: Our results did not support a consistent association between PFAS and MetS and conflicting findings were observed for individual components of MetS.

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Association between per and polyfluoroalkyl substances and markers of inflammation and oxidative stress

Cited by 98 publications

References 38 publications

Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors

Prenatal PFAS and psychosocial stress exposures in relation to fetal growth in two pregnancy cohorts: Applying environmental mixture methods to chemical and non-chemical stressors

Associations between PFAS occurrence and multimorbidity as observed in an electronic health record cohort

Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

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