Association between periodontal disease and oral squamous cell carcinoma: a systematic review and meta-analysis

Li, Rui; Hou, Mengjie; Yu, Lei; Wen, Li; Liu, Ruihan; Wang, Hongyan

doi:10.1016/j.bjoms.2023.05.004

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…[ 5 ] Limited studies have been conducted to establish a clear and comprehensive understanding of the relationship between the pathogenesis of periodontitis and OSCC. [ 5 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

Analyzing Pooled Microarray Gene Expression Data to Uncover Common Pathways in Periodontitis and Oral Squamous Cell Carcinoma from the Gene Expression Omnibus

Karri,

Amrutha,

Shrinivas

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Periodontitis and oral squamous cell carcinoma (OSCC) are prevalent oral diseases with distinct etiologies, yet they share certain molecular and biological characteristics. Gene expression datasets from the gene expression omnibus (GEO) repository (GSE30784 for OSCC and GSE10334 for periodontitis) were analyzed. Data preprocessing and differential gene expression analysis using GEO2R identified common differentially expressed genes (DEGs), and FunRich software facilitated the construction of a protein-protein interaction (PPI) network on the STRING database. Cytoscape, coupled with the CytoHubba plugin, identified Cluster of Differentiation 19 (CD19) and Von Willebrand Factor (VWF) as the top hub genes, with Complement C3 (C3) also highly ranked. Functional enrichment analysis highlighted pathways such as the B-cell receptor signaling pathway, complement and coagulation cascades, and hematopoietic cell lineage. Additionally, miRNet analysis identified key miRNAs, including hsa-mir-26a-5p, hsa-mir-129-2-3p, and hsa-mir-27a-3p, associated with these pathways. These findings suggested an association of molecular mechanisms between periodontitis and OSCC, with identified hub genes and miRNAs potentially serving as therapeutic targets.

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“…[ 5 ] Limited studies have been conducted to establish a clear and comprehensive understanding of the relationship between the pathogenesis of periodontitis and OSCC. [ 5 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

Analyzing Pooled Microarray Gene Expression Data to Uncover Common Pathways in Periodontitis and Oral Squamous Cell Carcinoma from the Gene Expression Omnibus

Karri,

Amrutha,

Shrinivas

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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show abstract

“…It is posited that the microbiota promotes oncogenesis by inducing inflammation, producing carcinogenic substances, and inhibiting apoptosis [ 11 ]. A connection between periodontitis and OSCC was explored, and a positive association has been indicated [ [12] , [13] , [14] , [15] ].…”

Section: Introductionmentioning

confidence: 99%

Dysbiosis linking periodontal disease and oral squamous cell carcinoma-A brief narrative review

Acharya,

Hegde,

Acharya

et al. 2024

Heliyon

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Re: Association between periodontal disease and oral squamous cell carcinoma: a systemic review and meta-analysis

Sethi,

Kumar Bhagania,

Uribe Rivera

2023

British Journal of Oral and Maxillofacial Surgery

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Association between periodontal disease and oral squamous cell carcinoma: a systematic review and meta-analysis

Cited by 7 publications

References 46 publications

Analyzing Pooled Microarray Gene Expression Data to Uncover Common Pathways in Periodontitis and Oral Squamous Cell Carcinoma from the Gene Expression Omnibus

Analyzing Pooled Microarray Gene Expression Data to Uncover Common Pathways in Periodontitis and Oral Squamous Cell Carcinoma from the Gene Expression Omnibus

Dysbiosis linking periodontal disease and oral squamous cell carcinoma-A brief narrative review

Re: Association between periodontal disease and oral squamous cell carcinoma: a systemic review and meta-analysis

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