Association between Periodontitis and Gene polymorphisms of hBD-1 and CD14: a meta-analysis

Chen, Chen; Fan, Xiaomiao; Yu, Shiwen; Liu, Peicheng; Pan, Yaping; Li, Lin; Li, Chen

doi:10.1016/j.archoralbio.2019.05.029

Cited by 7 publications

(9 citation statements)

References 42 publications

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“…Based on previous literature reports, we selected four DEFB1 gene single nucleotide polymorphisms, namely rs11362, rs1800972, rs1799946, and rs1047031, which could potentially influence the risk of oral cavity disorders.However, although some of the published data suggested a correlation between DEFB1 gene polymorphisms located in the 5' promoter region at positions rs11362, rs1800972, and rs1799946 and the risk of oral pathologies,10,[16][17][18] we were unable to find it significant. Consistent with our observations, recent meta-analyses performed by Chen et al and by Zhong et al did not reveal any significant associations between those polymorphisms and the risk of periodontitis 23,24. However, the latter authors identified DEFB1-G1654A polymorphism as a potential genetic susceptibility factor for periodontitis.…”

supporting

confidence: 92%

Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362

Ślebioda

Woźniak

Dorocka‐Bobkowska

et al. 2020

J Oral Pathology Medicine

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Objectives The purpose of this meta‐analysis was to reveal a potential association of the four functional polymorphisms in human Beta‐defensin 1 (DEFB1) gene: rs1047031(c*5G > A) at 3’UTR and rs11362 (−20 G > A), rs1800972(−44 C > G), and rs1799946 (−52 G > A) at 5’UTR with the risk of common oral cavity pathologies that included periodontitis, caries, lichen planus, and recurrent aphthous stomatitis. Methods The relevant studies were obtained by the two researchers from PubMed, Scopus, and Web of Science up to April 29, 2020. The manual search of the reference lists was also performed. Studies on DEFB1 gene polymorphisms and oral cavity disorders, using the case‐control genetic association analysis approach, and published as full texts in English were included. To assess the association strength, odds ratios (ORs) with their 95% confidence intervals (CIs) were extracted. Results Thirteen publications met the inclusion criteria and were incorporated in this meta‐analysis. Statistically significant values of the association tests were found only for the rs1047031 polymorphism. Allele distribution in the rs1047031 polymorphism was significantly associated with susceptibility to oral cavity pathologies (adjusted P value = 0.003). The rare variant allele carriers had a significantly higher risk for oral disasters under recessive (CC vs CT + TT), and CC vs CT models. No significant correlations between rs11362, rs1800972, and rs1799946 and the risk of oral pathologies were revealed. Conclusions Significant association between rs1047031 polymorphism and risk of oral pathologies has been found, and therefore, we suggest to include this polymorphism in future research concerning the genetic background of the oral cavity diseases.

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supporting

confidence: 92%

Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362

Ślebioda

Woźniak

Dorocka‐Bobkowska

et al. 2020

J Oral Pathology Medicine

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“…The current smoking prevalence is much lower in females than in males; however, cigarette and shish smoking are potential threats and affect all general populations (Bassiony 2009). In this investigation, we aimed to examine the present hypothesis: CS might contribute to nucleotide changes in the HBD-1 gene, which might lead to the initiation of multiple smoking-related diseases (Wang et al 2015;Slebioda et al 2021;Loo et al 2012;Chen et al 2019) such as chronic periodontitis (Zupin et al 2017), and chronic obstructive pulmonary disease (Matsushita et al 2002). Consequently, we aimed to identify the possible associations between HBD-1 polymorphisms rs1047031, rs1799946, rs2738047, and rs11362 and smoking by investigating the polymorphic distributions and effects on different parameters between smokers and non-smokers control among the Saudi population.…”

Section: Discussionmentioning

confidence: 99%

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

Almutairi

et al. 2021

Environ Sci Pollut Res

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Human β-defensin (HBD), a member of the antimicrobial peptides, is essential for respiratory epithelial cells’ microbial defense, and is affected by cigarette smoking (CS). Its expression is upregulated by stimulation from microbes or inflammation. Genetic polymorphisms in the HBD-1 gene have been implicated in the development of various smoking-related diseases, including chronic obstructive pulmonary disease and asthma. Thus, we sought to analyze possible associations between HBD-1 single-nucleotide polymorphism (SNP) in HBD-1 gene and CS in ethnic Saudi Arabian subjects. Variants rs1047031 (C/T), rs1799946 (C/T), rs2738047 (C/T), and rs11362 (C/T) were investigated by genotyping 575 blood specimens from males and females, smokers/non-smokers: 288/287. The CT and CT+TT genotypes of rs1799946 presented an ~5-fold increased correlation with CS among the female smokers, compared with the female controls (OR = 5.473, P = 0.02003; and OR = 5.211, P = 0.02028, respectively), an observation similar to rs11362 SNP in female smokers, but with protective effects in TT genotype, compared with the CC reference allele (OR = 0.143, P = 0.04368). In shisha smokers, the heterozygous CT and the CT/TT genotype of rs2738047 polymorphism showed the same results with ~3-fold increased correlation with CS (OR = 2.788; P = 0.03448), compared with the cigarette smokers category. No significant association was shown in genotypic distributions and allelic frequencies of rs1047031. Further investigations, including large study samples, are required to investigate the effects of shisha on human beta-defensin expression and protein levels.

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“…But in contrast, other case-control studies did not confirm this association [ 29 , 30 ]. However, in meta-analyses, no association of rs2569190 in the CD14 gene with periodontitis could be confirmed [ 15 , 31 ]. Furthermore, applying stratified analysis by ethnicity and the severity of periodontitis, no significant associations were assessed between CD14 SNP rs2569190 and periodontitis [ 15 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, in meta-analyses, no association of rs2569190 in the CD14 gene with periodontitis could be confirmed [ 15 , 31 ]. Furthermore, applying stratified analysis by ethnicity and the severity of periodontitis, no significant associations were assessed between CD14 SNP rs2569190 and periodontitis [ 15 , 31 ]. Investigating the impact of these SNPs on the occurrence of aggressive or chronic periodontitis, a meta-analysis was performed [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to their functional consequences, all described SNPs are highly involved in the immune response and could thus represent a possible link between periodontal and cardiovascular diseases. And indeed, in a variety of case-control studies as well as in meta-analyses, their impact on periodontitis as well as CV diseases was assessed (CD14 [15][16][17], NF-κΒ [14,18,19], TLR2 [20,21], and TLR4 [4,22,23]).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

Schulz

Zielske

Schneider

et al. 2021

Mediators of Inflammation

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Background. The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system—(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-κΒ (NF-κB)—was investigated. Materials and Methods. In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe periodontitis as well as on CV outcome was assessed. Results. All investigated genetic variants were not associated with preexisting CV events or severe periodontitis in CV patients. In Kaplan-Meier survival analyses, the CT genotype of CD14 single-nucleotide polymorphism (SNP) rs2569190 was shown to be an independent predictor for combined CV endpoint (log rank: p = 0.035 ; cox regression; hazard ratio: 1.572; p = 0.044 ) as well as cardiovascular death (log rank: p = 0.019 ; cox regression; hazard ratio: 1.585; p = 0.040 ) after three years of follow-up. Conclusions. SNPs in CD14, NF-κΒ, TLR2, and TLR4 are no risk modulators for preexisting CV events or severe periodontitis in CV patients. The CT genotype of CD14 SNP rs2569190 provides prognostic value for further CV events within 3 years of follow-up.

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Association between Periodontitis and Gene polymorphisms of hBD-1 and CD14: a meta-analysis

Cited by 7 publications

References 42 publications

Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362

Beta‐defensin 1 gene polymorphisms in the pathologies of the oral cavity—Data from meta‐analysis: Association only with rs1047031 not with rs1800972, rs1799946, and rs11362

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

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