Association between periodontitis and metabolic syndrome: A case‐control study

Abstract

BackgroundOver the past few years, the association between metabolic disorders and periodontitis has been widely studied and recognized. However, the relationship between metabolic syndrome (MetS) and periodontitis remains controversial. The aim of the present case‐control (1:3) study is to evaluate the potential association between periodontitis and MetS, as well as the influence of risk variables on this association.MethodsSamples comprised 122 individuals with MetS (cases) and 366 controls. Plaque index, probing depth, clinical attachment level, and bleeding on probing were evaluated through a full‐mouth periodontal examination. The association between risk variables, MetS, and periodontitis was tested through univariate analysis and multivariate logistic regression.ResultsA high prevalence of periodontitis was observed among cases (54.6%) when compared with controls (45.4%). Significant variables associated with the occurrence of periodontitis in the final logistic model were: MetS (odds ratio [OR] = 2.02; P = 0.003), number of teeth ≤14 (OR = 1.78; P = 0.034), and smoking (OR = 2.19; P = 0.001).ConclusionsAn important risk association between MetS and periodontitis was reported, being that individuals with MetS presented worse periodontal status and higher prevalence, severity, and extension of periodontitis.

Relationship between Apical Periodontitis and Metabolic Syndrome and Cardiovascular Events: A Cross-Sectional Study

“…A study including 8314 participants found an OR = 1.4 ( p < 0.05) for the association between periodontal disease and MetS [ 63 ]. A case-control study recently published found that patients with MetS presented worse periodontal status and higher prevalence, severity, and extension of periodontitis [ 64 ]. Dental caries, a component of TDI, has also been associated with MetS among the middle-aged urban Chinese population [ 65 ], and a recent study found an association between decayed teeth and MetS [ 66 ].…”

Association of periodontitis with metabolic syndrome: A case-control study

“…Metabolic syndrome (MetS) is defined as the combination of three out of five of the following interrelated conditions: increased plasma glucose, hypertension, dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein [HDL]), and/or elevated abdominal circumference. [ 1 ] Abdominal obesity, hypertension, and hyperglycemia are the most frequently occurring components of MetS. [ 2 ] MetS is multifactorial disorder, also known by other names such as Reaven’s syndrome, insulin resistance syndrome, plurimetabolic syndrome, syndrome X, and the deadly quartet.…”

“…[ 2 ] Periodontitis is becoming an important public health concern with different severity rates in individuals, synchronizing with other systemic conditions. [ 1 ]…”

“…MetS and periodontitis are linked through common risk factors and pathways, sharing inflammation and oxidative stress/mitochondrial dysfunction mechanism as a common link. 1 8 ] Thus, chronic systemic inflammation accelerates an individual with periodontitis to develop MetS or vice versa. [ 1 ] However, other studies reported different strengths of association, including tobacco, gender, and age as confounding factors while evaluating the association between MetS and periodontitis.…”

“… 1 8 ] Thus, chronic systemic inflammation accelerates an individual with periodontitis to develop MetS or vice versa. [ 1 ] However, other studies reported different strengths of association, including tobacco, gender, and age as confounding factors while evaluating the association between MetS and periodontitis. A very little information is available on the association between periodontitis and MetS as a sole clinical entity in Indian population.…”