Association Between Perioperative Fibrinogen Levels and the Midterm Outcome in Patients Undergoing Elective Endovascular Repair of Abdominal Aortic Aneurysms

Kapetanios, Dimitrios; Karkos, Christos D.; Pliatsios, Ioannis; Mitka, Maria; Giagtzidis, Ioakeim T.; Konstantinidis, Konstantinos; Papazoglou, Konstantinos

doi:10.1016/j.avsg.2018.09.021

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…In the mechanism underlying AAA rupture prevention by EVAR, it is thought that thrombi formed by blood trapped between the aneurysm wall and the stentgraft (SG) placed within the AAA become a structure that supports the SG, which excludes the aneurysm from systemic circulation and pressure within the aneurysm becomes lower than systemic pressure. 3) Therefore, aortic aneurysm diameter shrinkage following EVAR is considered a predictor of good long-term prognosis, such as high free rate for secondary intervention, EVAR-related complication, and good survival rate. 2) As factors influencing on the long-term prognosis of EVAR, endoleak with residual blood flow in the aneurysm sac has a major impact, and HP-EL such as type I and type III, with these endoleaks, intra-aneurysm sac pressure would be high, are known to be risk factors of AAA rupture following EVAR from the time of SG introduction and are thought to require early treatment.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing on the Aneurysm Sac Shrinkage after Endovascular Abdominal Aortic Aneurysm Repair by the Analysis of the Patients with the Aneurysm Sac Shrinkage and Expansion

Aoki,

Maruta,

Masuda

et al. 2023

Annals of Vascular Diseases

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therapy (40.5% vs. 66.7%, p = 0.044) and TXA (79.8% vs. 38.9%, p <0.001), were significantly associated with sac shrinkage. By multivariate analysis, the odds ratio of sac shrinkage was 11.7 for males, 0.1 for the patients on antiplatelet therapy, and 6.5 for the patient who received TXA. The patients with patent inferior mesenteric artery (IMA) were less in the shrinkage group (20.3% vs. 77.8%, p <0.001) and with two or less patent lumbar arteries (LAs) were more in the shrinkage group (82.3% vs. 33.3%, p < 0.001). The odd ratio of sac shrinkage was 7.8 for occluded IMA and 3.9 for two or less patent LAs. Conclusion:The possibility of sac shrinkage would be high for the patient with occluded IMA and two or less patent LA at the end of EVAR, and that patient received TXA after EVAR.

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Section: Discussionmentioning

confidence: 99%

Factors Influencing on the Aneurysm Sac Shrinkage after Endovascular Abdominal Aortic Aneurysm Repair by the Analysis of the Patients with the Aneurysm Sac Shrinkage and Expansion

Aoki,

Maruta,

Masuda

et al. 2023

Annals of Vascular Diseases

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“…The authors noted that there was no significant association between perioperative fibrinogen levels and post-operative endoleak, lower limb ischemia, or need for re-intervention. They did note, however, that patients with endoleak had higher median levels of fibrinogen compared to those with no endoleak [ 9 ].…”

Section: Prognostic Protein Categorization and Functionsmentioning

confidence: 99%

Current Prognostic Biomarkers for Abdominal Aortic Aneurysm: A Comprehensive Scoping Review of the Literature

Khan,

Abu-Raisi,

Feasson

et al. 2024

Biomolecules

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Abdominal aortic aneurysm (AAA) is a progressive dilatation of the aorta that can lead to aortic rupture. The pathophysiology of the disease is not well characterized but is known to be caused by the general breakdown of the extracellular matrix within the aortic wall. In this comprehensive literature review, all current research on proteins that have been investigated for their potential prognostic capabilities in patients with AAA was included. A total of 45 proteins were found to be potential prognostic biomarkers for AAA, predicting incidence of AAA, AAA rupture, AAA growth, endoleak, and post-surgical mortality. The 45 proteins fell into the following seven general categories based on their primary function: (1) cardiovascular health, (2) hemostasis, (3) transport proteins, (4) inflammation and immunity, (5) kidney function, (6) cellular structure, (7) and hormones and growth factors. This is the most up-to-date literature review on current prognostic markers for AAA and their functions. This review outlines the wide pathophysiological processes that are implicated in AAA disease progression.

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“…Platelets, in conjugation with endothelial cells and coagulation proteins, are the crucial mediator of vascular hemostasis and thrombosis. Disruption to any of these processes could result in atherosclerotic plaque formation [9][10][11] (Figure 2, leading to variety of thrombotic diseases including CVDs (cardiovascular diseases) [12,13], abdominal aortic aneurysms (AAAs) [14,15], pulmonary embolism (PE) [16], and stroke [17,18]. The process of hemostasis is divided into two stages: (1) primary (involves rapid platelet activation) and (2) secondary (requires additional coagulation pathways to form polymeric fibrin) processes (Table 1).…”

Section: Mechanism Of Thrombus Formationmentioning

confidence: 99%

“…Platelets, in conjugation with endothelial cells and coagulation proteins, are the crucial mediator of vascular hemostasis and thrombosis. Disruption to any of these processes could result in atherosclerotic plaque formation [ 9 , 10 , 11 ] ( Figure 2 , leading to variety of thrombotic diseases including CVDs (cardiovascular diseases) [ 12 , 13 ], abdominal aortic aneurysms (AAAs) [ 14 , 15 ], pulmonary embolism (PE) [ 16 ], and stroke [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Thrombolytic Enzymes of Microbial Origin: A Review

Diwan

Usmani

Sharma

et al. 2021

IJMS

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Enzyme therapies are attracting significant attention as thrombolytic drugs during the current scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various sources, the application of microbial-derived thrombolytic and fibrinolytic enzymes to prevent and treat vascular occlusion is promising due to their advantageous cost–benefit ratio and large-scale production. Thrombotic complications such as stroke, myocardial infarction, pulmonary embolism, deep venous thrombosis, and peripheral occlusive diseases resulting from blood vessel blockage are the major cause of poor prognosis and mortality. Given the ability of microbial thrombolytic enzymes to dissolve blood clots and prevent any adverse effects, their use as a potential thrombolytic therapy has attracted great interest. A better understanding of the hemostasis and fibrinolytic system may aid in improving the efficacy and safety of this treatment approach over classical thrombolytic agents. Here, we concisely discuss the physiological mechanism of thrombus formation, thrombo-, and fibrinolysis, thrombolytic and fibrinolytic agents isolated from bacteria, fungi, and algae along with their mode of action and the potential application of microbial enzymes in thrombosis therapy.

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Association Between Perioperative Fibrinogen Levels and the Midterm Outcome in Patients Undergoing Elective Endovascular Repair of Abdominal Aortic Aneurysms

Cited by 10 publications

References 27 publications

Factors Influencing on the Aneurysm Sac Shrinkage after Endovascular Abdominal Aortic Aneurysm Repair by the Analysis of the Patients with the Aneurysm Sac Shrinkage and Expansion

Factors Influencing on the Aneurysm Sac Shrinkage after Endovascular Abdominal Aortic Aneurysm Repair by the Analysis of the Patients with the Aneurysm Sac Shrinkage and Expansion

Current Prognostic Biomarkers for Abdominal Aortic Aneurysm: A Comprehensive Scoping Review of the Literature

Thrombolytic Enzymes of Microbial Origin: A Review

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