Association between physical activity and thyroid function in American adults: a survey from the NHANES database

Tian, Lijun; Lu, Cihang; Teng, Weiping

doi:10.1186/s12889-024-18768-4

BMC Public Health

2024

DOI: 10.1186/s12889-024-18768-4

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Association between physical activity and thyroid function in American adults: a survey from the NHANES database

Lijun Tian,

Cihang Lu,

Weiping Teng

Abstract: Objective Physical activity (PA) is closely related to our lives, and the effects of PA on thyroid function have not been elucidated. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2012, we included 5877 participants and analyzed the associations of thyroid function with weekly physical activity (PAM, expressed in metabolic equivalents of task) and physical activity time (PAT) in American adults. Univaria… Show more

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Cited by 3 publications

References 52 publications

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Effect of physical exercise on metabolism in patients with atrial fibrillation

Wang,

Weng,

Xia

et al. 2024

Front. Cardiovasc. Med.

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Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is closely linked to metabolic dysfunctions, including obesity, diabetes, and dyslipidemia. These lead to pathological changes in myocardial metabolism and mitochondrial energy metabolism, thereby aggravating AF's incidence and severity. This review introduces the role of metabolic dysfunctions in exacerbating AF, assesses the therapeutic potential of physical exercise and investigates it as a non-pharmacological intervention to alleviate these metabolic disturbances. Evidence suggests that regular physical activity not only enhances metabolic profiles but also reduces the frequency of AF episodes and improves overall cardiovascular health. At the same time, the review emphasizes the need for individualized exercise regimens, individualized to the metabolic and cardiac conditions of each patient to optimize benefits and minimize risks. Additionally, it calls for more basic studies and large-scale clinical trials to establish and refine evidence-based exercise guidelines specific to AF management.

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Effect of physical exercise on metabolism in patients with atrial fibrillation

Wang,

Weng,

Xia

et al. 2024

Front. Cardiovasc. Med.

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Association between FT3 Levels and Exercise-Induced Cardiac Remodeling in Elite Athletes

Di Gioia,

Squeo,

Lemme

et al. 2024

Biomedicines

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Background: Previous studies demonstrated that variations of fT3, even within the euthyroid range, can influence cardiac function. Our aim was to investigate whether thyroid hormones, even within the euthyroid range, are associated with the magnitude of exercise-induced cardiac remodeling in Olympic athletes. Methods: We evaluated 1342 Olympic athletes (mean age 25.6 ± 5.1) practicing different sporting disciplines (power, skills, endurance, and mixed). Athletes underwent blood testing (thyroid stimulating hormone, fT3, and fT4), echocardiography, and exercise-stress testing. Athletes taking thyroid hormones, affected by thyroiditis, or presenting TSH out of ranges were excluded. Results: The level of thyroid hormones varied according to the type of sporting discipline practiced: endurance athletes presented the lowest TSH (p < 0.0001), fT3 (p = 0.007), and fT4 (p < 0.0001) in comparison to the remaining ones. Resting heart rate (HR) was positively correlated to fT3 in athletes of different disciplines (power: p = 0.0002, R2 = 0.04; skill: p = 0.0009, R2 = 0.05; endurance: p = 0.007, R2 = 0.03; and mixed: p = 0.04, R2 = 0.01). The same results were seen for peak HR in the exercise-stress test in athletes engaged in power, skill, and endurance (respectively, p < 0.0001, R2 = 0.04; p = 0.01, R2 = 0.04; and p = 0.005, R2 = 0.02). Moreover, a positive correlation was observed with cardiac dimensions, i.e., interventricular septum (power: p < 0.0001, R2 = 0.11; skill: p = 0.02, R2 = 0.03; endurance: p = 0.002, R2 = 0.03; mixed: p < 0.0001, R2 = 0.04). Furthermore, fT3 was directly correlated with the left ventricle (LV) end-diastolic volume in skills (p = 0.04, R2 = 0.03), endurance (p = 0.04, R2 = 0.01), and mixed (p = 0.04, R2 = 0.01). Conclusions: Thyroid hormones, even within the euthyroid range, are associated with cardiac adaptive response to exercise and may contribute to exercise-induced cardiac remodeling.

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Assessment of Thyroid Profile in Pregnancy-associated Hypertensive Disorders

Aziz

2024

King Khalid University Journal of Health Sciences

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Background: Hypertensive disorders of pregnancy (HDP), affect approximately 10.92% of pregnancies globally, with a notable prevalence in Saudi Arabia. Aims and Objectives: This study aims to assess the thyroid hormone profile in pregnant women diagnosed with normotensive conditions, gestational hypertension, and preeclampsia. Material and Methods: The cross-sectional study includes total of 147 pregnant women, categorized into three groups based on clinical diagnosis: preeclampsia (n=50), gestational hypertension (n=47), and normotensive controls (n=50). Blood pressure was recorded on more than two occasions after 20 weeks of gestation. Proteinuria was assessed using the dipstick method in a 24-hour urine sample. The levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free tetra iodothyronine (FT4) were estimated using the ELISA method. Based on the interpretation of laboratory results and clinical conclusion, study subjects were grouped as thyroid dysfunction types. Statistical analysis was performed using ANOVA followed by Tukeys Honest test at 0.001 level of significance. Results: The results indicate significant difference in general characteristics among the three groups at 0.001 level. Overall thyroid profile parameters showed no significant difference among the groups. Mean TSH was increased in all groups with no significant difference. A total of 4% of study subjects in all groups reported subclinical hypothyroidism, whereas 2% reported subclinical hyperthyroidism. Conclusion: The study shows that while thyroid profile parameters were elevated in gestational hypertension, there was no significant difference compared to controls. It also found that 4% of participants had subclinical hypothyroidism, and 2% had subclinical hyperthyroidism. The study highlights the need for multicenter research to improve understanding and generalizability of thyroid dysfunction in gestational hypertension.

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Association between physical activity and thyroid function in American adults: a survey from the NHANES database

Cited by 3 publications

References 52 publications

Effect of physical exercise on metabolism in patients with atrial fibrillation

Effect of physical exercise on metabolism in patients with atrial fibrillation

Association between FT3 Levels and Exercise-Induced Cardiac Remodeling in Elite Athletes

Assessment of Thyroid Profile in Pregnancy-associated Hypertensive Disorders

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