Association between physical activity and risk of prevalent psoriasis

Zheng, Qi; Miao, Xiao; Xu, Rong; Ma, Tian; Zhang, Ya Nan; Li, Hong Jin; Li, Bin; Li, Xin

doi:10.1097/md.0000000000011394

Cited by 21 publications

(23 citation statements)

References 47 publications

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“…Gisondi et al ( 18 ) reported that SUA levels were significantly higher in obese patients than in non-obese patients with psoriasis. Zheng et al ( 45 ) highlighted the fact that intense physical activity lowered the prevalence of psoriasis by reducing fat accumulation. Our meta-analysis showed that SUA levels were significantly higher in patients with moderate to severe psoriasis in European and American regions and Southeast Asia.…”

Section: Discussionmentioning

confidence: 99%

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Zhang

Liu

Sun³

et al. 2021

Front. Med.

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Background: Our earlier meta-analysis showed that the correlation between psoriasis and hyperuricemia might be region-dependent and that hyperuricemia was more common in patients with psoriasis in Western Europe. However, no further analysis could be conducted owing to the scarcity of data.Objective: Our study aimed to further explore the association between psoriasis and hyperuricemia.Methods: Six databases (PubMed, Embase, the Cochrane Central Register of Controlled Trials, the China National Knowledge Infrastructure database, the Chinese Scientific Journals Full Text Database, and the Wanfang Data Knowledge Service Platform) were searched for studies published between January 1980 and February 2021.Results: The search strategy yielded 291 relevant studies, of which 27 observational studies were included in this analysis. Serum uric acid (SUA) levels (mean difference [MD] 0.99, 95% confidence interval [CI] 0.48–1.49, P = 0.0001) and hyperuricemia frequency (odds ratio [OR] 5.39, 95% CI 1.88–15.40, P = 0.002) were higher in the psoriasis group than in the control group, and the subgroup differences were significant. In addition, SUA levels were significantly higher in patients with moderate to severe psoriasis from European and American countries (MD 0.89, 95% CI 0.18–1.60, P = 0.01) and Southeast Asia (MD 1.79, 95% CI 0.55–3.02, P = 0.004), while no significant differences were found between the Middle East subgroup (MD 0.63, 95% CI −0.33 to 1.59, P = 0.20). Similar results were obtained from the meta-analysis of SUA levels in patients with metabolic syndrome, obesity, or a special type of psoriasis (such as arthritic or erythrodermic psoriasis).Conclusions: Our meta-analysis study provides extended data regarding the correlation between psoriasis and hyperuricemia and the differences in SUA levels between psoriasis patients and controls in Southeast Asia, the Middle East, and European and American countries. Patients with moderate to severe psoriasis in European and American countries and Southeast Asia or those with metabolic syndrome and obesity were more likely to have higher uric acid levels.Systematic Review Registration: PROSPERO, identifier: CRD42014015091.

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Section: Discussionmentioning

confidence: 99%

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Zhang

Liu

Sun³

et al. 2021

Front. Med.

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“…A recently published meta-analysis combined data of 13 studies including a total of 149,499 participants [ 46 ]. There was no significant difference in the level of exercise between people without and with psoriasis when analyzed for the overall effect but the subgroup analysis showed that patients with psoriasis performed vigorous exercises significantly less than controls (RR 0.76; 95% CI 0.67–0.85; p < 0.00001).…”

Section: Association Between Psoriasis and Cardiovascular Risk Factormentioning

confidence: 99%

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Masson

Lobo²,

Molinero³

2020

Adv Ther

129

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Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular disorders. The high incidence of cardiovascular events in the population with psoriasis could be explained by several mechanisms. The high prevalence of traditional cardiovascular risk factors and metabolic abnormalities contributes to the high cardiovascular burden in patients with psoriasis. Likewise, the presence of systemic inflammation in combination with metabolic abnormalities may act in a synergistic manner to increase cardiovascular risk in these patients. This review focused on epidemiologic and clinical evidence linking psoriasis to cardiovascular risk factors and cardiovascular disease. We described the possible pathophysiological mechanisms that justify this association and analyzed the best way to stratify the cardiovascular risk in patients with psoriasis. We also described the usefulness of the therapies frequently used in cardiovascular prevention and analyzed the impact of the specific psoriasis medication on cardiovascular risk factors or major atherosclerotic events. Knowledge of the application of different cardiovascular prevention strategies could mean an advantage in performing the difficult task of estimating cardiovascular risk and treating cardiovascular risk factors in this particular group of patients.

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“…Furthermore, the severity of psoriasis is significantly correlated with comorbidities [40,41]. Although psoriasis is not an immediately life-threatening disease, it still reduces the quality of life of patients and brings a heavy economic burden on society [42]. Additionally, some patients with psoriasis, especially women, will have quite serious psychological disorders that will [43,44].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Jueyin Granules for Patients with Mild‐to‐Moderate Psoriasis Vulgaris: Protocol for a Multicenter Randomized Placebo‐Controlled Trial

Zhang

Hong-ya

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. The etiology and pathogenesis of psoriasis are complex. Blood-heat syndrome is the core pathogenesis of psoriasis. Based on theories of Chinese medicine (CM), heat-clearing and blood-cooling (HCBC) are the primary treatment. Very few studies have investigated the pharmacological mechanism of the CM HCBC method for treating psoriasis. This multicenter randomized controlled trial will focus on treating psoriasis blood-heat syndrome with the HCBC method using Jueyin granules (JYKL). This will be an objective and standardized evaluation of the efficacy, safety, and reproducibility of the HCBC method to obtain objective evidence meeting international standards that aim to establish a clinical standard suitable for the popular application of CM for treating psoriasis. Methods and Analysis. A five-center randomized double-blind placebo-controlled clinical design will be used in this study. At least 196 participants will be randomly assigned to receive either JYKL or placebo treatment approximately 30 minutes after meals in the morning and evening (one sachet per time, twice daily for 8 consecutive weeks). The study duration will be 17 weeks, including 1 week of screening, 8 weeks of intervention, and 8 weeks of follow-up. The patients will be evaluated every 2 weeks, and the measures will be compared with baseline values. The primary outcome measure will be the psoriasis lesion area severity index. We will also observe the recurrence rate, body surface area, physician global assessment, dermatology life quality index, quality of life index, visual analogue scale score, CM symptom score, combined drug use, and adverse events. This trial is registered with NCT03961230.

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Association between physical activity and risk of prevalent psoriasis

Cited by 21 publications

References 47 publications

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Updated Evidence of the Association Between Elevated Serum Uric Acid Level and Psoriasis

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Efficacy and Safety of Jueyin Granules for Patients with Mild‐to‐Moderate Psoriasis Vulgaris: Protocol for a Multicenter Randomized Placebo‐Controlled Trial

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