Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

Li, You; He, Kunlun; Cao, Lei; Xu, Tao; Gou, Ruoyu; Luo, Tingyu; Song, Xiaomin; Chen, Ziqi; Li, Tingjun; Qin, Jianguang; Zhang, Zhiyong; Cai, Jiansheng

doi:10.1186/s12882-022-02945-x

Cited by 3 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The non-linear association indicates that earlier intervention, instead of >1 µg/g, may provide more benefits. A similar significant association was also observed in two previous studies (15,16). Of note, in a cohort study with an ample sample size (35,545 men and 33,050 women), no significant association was found between dietary cadmium intake and kidney stones (hazard ratio = 0.97 for men and 0.99 for women), contrary to our findings (11).…”

Section: Discussionsupporting

confidence: 91%

“…Some observational studies have preliminarily examined the association between cadmium and kidney stone. In the United States, Ferraro et al (10) included 15,690 participants and found that women with urinary cadmium >1 µg/g had a 1.40-fold risk of renal stones. Contrary to their findings, Thomas et al (11) reported that dietary cadmium was not associated with kidney stone risk in two large prospective cohorts in the general population.…”

mentioning

confidence: 99%

See 1 more Smart Citation

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Zai-zhi

Luo

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundThe association between urinary cadmium and kidney stone risk is inconsistent in previous studies, which needs further exploration. This study was performed to explore the association between urinary cadmium and kidney stone.Materials and methodsData from the National Health and Nutrition Examination Survey (2011–2020) were included and further analyzed. Urinary cadmium was stratified into quartiles with quartile 1 (Q1: 0.025–0.104 μg/L) and quartile 4 (Q4: 0.435–7.581 μg/L). Further weighted logistic regression was adopted to evaluate the association between urinary cadmium and kidney stone. A subgroup analysis was used to verify the findings. The non-linear association was examined using the restricted cubic spline (RCS) regression.ResultsA total of 9,056 adults aged 20 years and above were included in this study. In the fully adjusted model, an increased risk of kidney stones was identified for quartile 2 (OR = 1.40, 95% CI = 1.06–1.84, P < 0.05), quartile 3 (OR = 1.18, 95% CI = 0.88–1.59, P > 0.05), and quartile 4 (OR = 1.54, 95% CI = 1.10–2.06, P < 0.05). A similar association was found between continuous cadmium increase and OR of kidney stones in the fully adjusted model (OR = 1.13, 95% CI = 1.01–1.26, P < 0.05). The RCS also indicated a non-linear association between urinary cadmium concentration and kidney stone risk (P for non-linear < 0.001).ConclusionIn summary, cadmium exposure is identified as a risk factor for kidney stones in this study. Their non-linear association makes demands on early intervention for the cadmium-exposed population. Medical interventions for kidney stone prevention should take cadmium exposure into account.

show abstract

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Zai-zhi

Luo

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…The concentration of Cd in non-contaminated soils can vary from 0.1–0.5 mg kg −1 ; nevertheless, human activities ( Figure 1 ) have increased Cd concentration to more than tolerable limits [ 5 ]. Cadmium can cause kidney stones, renal tube damage, emphysema, liver damage, and reduced calcium (Ca) supply to the human body [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Zinc Oxide Nanoparticles to Mitigate Cadmium Toxicity: Mechanisms and Future Prospects

Umair Hassan,

Huang,

Haider

et al. 2024

Plants

View full text Add to dashboard Cite

Cadmium (Cd), as the most prevalent heavy metal contaminant poses serious risks to plants, humans, and the environment. The ubiquity of this toxic metal is continuously increasing due to the rapid discharge of industrial and mining effluents and the excessive use of chemical fertilizers. Nanoparticles (NPs) have emerged as a novel strategy to alleviate Cd toxicity. Zinc oxide nanoparticles (ZnO-NPs) have become the most important NPs used to mitigate the toxicity of abiotic stresses and improve crop productivity. The plants quickly absorb Cd, which subsequently disrupts plant physiological and biochemical processes and increases the production of reactive oxygen species (ROS), which causes the oxidation of cellular structures and significant growth losses. Besides this, Cd toxicity also disrupts leaf osmotic pressure, nutrient uptake, membrane stability, chlorophyll synthesis, and enzyme activities, leading to a serious reduction in growth and biomass productivity. Though plants possess an excellent defense mechanism to counteract Cd toxicity, this is not enough to counter higher concentrations of Cd toxicity. Applying Zn-NPs has proven to have significant potential in mitigating the toxic effects of Cd. ZnO-NPs improve chlorophyll synthesis, photosynthetic efficiency, membrane stability, nutrient uptake, and gene expression, which can help to counter toxic effects of Cd stress. Additionally, ZnO-NPs also help to reduce Cd absorption and accumulation in plants, and the complex relationship between ZnO-NPs, osmolytes, hormones, and secondary metabolites plays an important role in Cd tolerance. Thus, this review concentrates on exploring the diverse mechanisms by which ZnO nanoparticles can alleviate Cd toxicity in plants. In the end, this review has identified various research gaps that need addressing to ensure the promising future of ZnO-NPs in mitigating Cd toxicity. The findings of this review contribute to gaining a deeper understanding of the role of ZnO-NPs in combating Cd toxicity to promote safer and sustainable crop production by remediating Cd-polluted soils. This also allows for the development of eco-friendly approaches to remediate Cd-polluted soils to improve soil fertility and environmental quality.

show abstract

Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report

Zheng

Yang

et al. 2023

Open Medicine

View full text Add to dashboard Cite

Nephrolithiasis is a highly prevalent disease worldwide that is associated with significant suffering, renal failure, and cost for the healthcare system. A patient with nephrolithiasis was found to have SLC6A20 variation. SLC6A20 gene in human is located on chromosome 3p21.3, which is a member of SLC6 family of membrane transporters and the product of this gene expression is transporter protein of sub-amino acid transporter system. The previous studies have reported that the mutation of SLC6A20 may cause hyperglycinuria or iminoglycinuria which may lead to nephrolithiasis. The object was to investigate the relationship between nephrolithiasis and SLC6A20 through pedigree genetic analysis. To explore whether the SLC6A20 mutation can cause hereditary nephrolithiasis, and provide evidence for further research. The urine and blood were collected from the patients for compositional analysis. DNA sequencing was applied to analyze the gene mutation. Labial gland and kidney biopsy were conducted for pathological analysis. As a result we reported a rare family case of nephrolithiasis accompanied by primary Sjogren’s syndrome and investigated it by examining the family members with whole exome gene sequencing technology and detecting 20 different amino acids and 132 kinds of organic acids in the urine with gas chromatography-mass spectrometry. We discovered that the proband and her mother had hyperglycinuria and the proband (Ⅱ2), her sister (Ⅱ3), and mother (Ⅰ1) were found to carry the SLC6A20 gene exon NM_020208.3 sequence c.1072T > C heterozygous mutation, and the other family members (Ⅰ2, Ⅱ1, Ⅱ4, Ⅲ1, Ⅲ2) did not carry the genetic mutation. As a conclusion, the heterozygous mutation of SLC6A20 (c.1072T > C) might be contributed to hyperglycinuria and the formation of nephrolithiasis.

show abstract

Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case–control study

Cited by 3 publications

References 41 publications

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Application of Zinc Oxide Nanoparticles to Mitigate Cadmium Toxicity: Mechanisms and Future Prospects

Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report

Contact Info

Product

Resources

About