Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women

Figueiredo, Amanda Faria de; Trujillo, Janet; Freitas-Vilela, Ana Amélia; Franco‐Sena, Ana Beatriz; Rebelo, Fernanda; Cunha, Geraldo Marcelo da; Castro, Maria Beatriz Trindade de; Farnum, Amanda; Mokhtar, Rana; Holick, Michael F.; Kac, Gilberto

doi:10.1016/j.jpsychires.2017.07.009

Cited by 21 publications

(19 citation statements)

References 42 publications

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“…Multiple studies have demonstrated that 25(OH)D deficiency during the first trimester of pregnancy is predictive of elevated depressive symptoms during the second and/or third trimesters (21)(22)(23) . In three of the studies reviewed here, the prevalence of 25(OH)D deficiency was ≥40 % (27,28,30) .…”

Section: Discussionmentioning

confidence: 99%

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Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Szpunar

2019

Public Health Nutr.

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ObjectivePostpartum depression affects up to 20 % of new mothers within the first 12 months of parturition. 25-Hydroxyvitamin D (25(OH)D) has known importance in bone health, but it may also play an important role in other functions, including reproduction and fertility, immune function and mental health. This clinical commentary reviews literature evaluating 25(OH)D deficiency during pregnancy and the incidence of postpartum depressive symptomatology.DesignNarrative review, summary and recommendations.Setting/ParticipantsA literature search revealed five relevant studies of antepartum women, three based in the USA, one in Turkey and one in Iran.ResultsThree of the five studies measured serum 25(OH)D concentrations during the first or second trimester and discovered an association with 25(OH)D deficiency and depressive symptoms postpartum. One study determined an almost significant (P=0·058) inverse relationship with first-trimester 25(OH)D concentration and depressive symptoms postpartum, and the last study, which was a secondary analysis, did not find an association.ConclusionsThe Endocrine Society recommends routine vitamin D supplementation during pregnancy and lactation due to increased metabolic demand in the mother, but a recent Cochrane review recommended against screening. Vitamin D should be the target of more studies during pregnancy and the postpartum period since it appears to have an important role for both medical and mental health. Vitamin D supplementation is a relatively safe and cost-effective intervention during pregnancy, and it may prove to be important in the prevention of postpartum depression.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated correlations of low 25(OH)D concentration in early pregnancy with increased depressive symptomatology later in pregnancy (21)(22)(23) . The present commentary encompasses the findings of currently published literature regarding 25(OH)D deficiency during pregnancy and depressive symptoms in the postpartum period.…”

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confidence: 99%

Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Szpunar

2019

Public Health Nutr.

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“…Among samples of pregnant women from Hanoi City and rural Hai Duong Province, Vietnam (15° N; n = 541), and from Thailand (14° N; n = 120) 48% and 47.2% were deemed insufficient, respectively, using a cut-off of <75 nmol/L [ 56 , 57 ]. More recently, in a Brazilian cohort of 229 pregnant women (23°S), the prevalence of 25(OH)D <75 nmo/L was 33.9% [ 58 ], while 13.2% of 910 pregnant women from Singapore (1°22′ N) had maternal concentrations <50 nmol/L [ 42 ]. Indeed, even within the current study, a degree of insufficiency was observed when using the 75 nmol/L cut-off.…”

Section: Discussionmentioning

confidence: 99%

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

et al. 2017

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Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4.6° S). This study was conducted in pregnant mothers originally recruited to the Seychelles Child Development Nutrition Study. Blood samples (n = 202) taken at delivery were analysed for serum 25-hydroxyvitamin D (25(OH)D) concentrations. Multiple linear regression models assessed associations between maternal 25(OH)D and birth weight, infant head circumference, and neurocognitive outcomes in the children at age 5 years. Mothers were, on average, 27 years of age, and the children’s average gestational age was 39 weeks. None of the women reported any intake of vitamin D supplements. Maternal 25(OH)D concentrations had a mean of 101 (range 34–218 nmol/L) and none were deficient (<30 nmol/L). Maternal 25(OH)D concentrations were not associated with child anthropometric or neurodevelopmental outcomes. These findings appear to indicate that a higher vitamin D status is not a limiting factor for neonatal growth or neurocognitive development in the first 5 years of life. Larger studies with greater variability in vitamin D status are needed to further explore optimal cut-offs or non-linear associations (including for maternal health) that might exist among populations with sub-optimal exposure.

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“…Os sintomas depressivos foram medidos a cada trimestre, utilizando-se a Escala Depressiva Pós-natal de Edimburgo, e a probabilidade de ocorrência de sintomas depressivos diminuiu ao longo da gravidez (p= 0,005). As mulheres com maiores concentrações de 25hidroxivitamina D no primeiro trimestre apresentaram menor odds ratio (OR) para o desenvolvimento de sintomas depressivos durante a gestação (CUNHA et al, 2017).…”

Section: Yan Et Al (2017)unclassified

Estratégias Dietéticas Para a Gestação E Lactação

Medeiros¹,

Araújo²,

Pereira³

2019

Enci Bio

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RESUMOEm virtude do pequeno número de estudos que analisam os benefícios de mudanças dietéticas no desenvolvimento da gestação, do parto e da lactação, esta revisão sistemática buscou investigar os efeitos da oferta de suplementação de nutrientes e outras modificações dietéticas, em desfechos desejáveis nos processos de gestação e lactação, bem como na prevenção de desfechos clínicos indesejáveis nos recém-nascidos. Foi estruturada conforme as recomendações Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), resultando na seleção de 11 artigos para comporem os resultados do estudo. Buscaram-se artigos originais, indexados às bases de dados eletrônicas PubMed Central (PMC); Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Scientific Eletronic Library Online (SciELO) e publicados entre 2008 e 2018, nos idiomas: português, inglês e espanhol. Os descritores estão listados no Medical Subject Heading (MeSH) -em inglês, e nos Descritores em Ciências da Saúde (DeCS)-em português. Com esse estudo pode-se observar a importância da nutrição durante o período gravídico puerperal e seu impacto na saúde materno-infantil. Nota-se que a qualidade de vida da mãe e, principalmente, a qualidade da sua alimentação são imprescindíveis para um bom desenvolvimento fetal. Sendo assim, a avaliação nutricional completa, com foco em uma intervenção precoce, para correção dos desvios diagnosticados, faz-se essencial durante todo o período gestacional e puerperal. PALAVRAS-CHAVE: Resultado da gravidez. Período pós-parto. Suplemento alimentar. DIETARY STRATEGIES FOR PREGNANCY AND LACTATION: A SYSTEMATIC REVIEWABSTRACT Because of the small number of studies that examine the benefits of dietary changes in the development of pregnancy, childbirth and lactation, this systematic review sought to investigate the effects of nutrient supplementation and other dietary changes on desirable outcomes in gestational processes and lactation, as well as in preventing undesirable clinical outcomes in newborns. It was structured according to

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Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women

Cited by 21 publications

References 42 publications

Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

Estratégias Dietéticas Para a Gestação E Lactação

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