Association between plasma viscosity and all‐cause mortality: results from the MONICA–Augsburg Cohort Study 1984–92

Köenig, Wolfgang; Sund, M.; Löwel, Hannelore; Döring, Angela; Ernst, E.

doi:10.1046/j.1365-2141.2000.02026.x

Cited by 37 publications

(19 citation statements)

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“…In contrast to two other prospective studies (Koenig et al, 2000;Lowe et al, 2000), plasma viscosity was not associated with incident mortality. Following adjustment for evidence of baseline CVD, and for classic cardiovascular risk factors (which were associated with baseline levels of blood viscosity determinants: Lowe et al, 1988), only fibrinogen (measured as clottable fibrinogen by the von Clauss assay) was significantly associated with mortality.…”

Section: Discussioncontrasting

confidence: 51%

“…Three prospective studies (the present; and Koenig et al, 2000, andLowe et al, 2000) have now shown that measures (or determinants) of blood viscosity are associated with incident mortality. However, the results of the present study, and of another prospective study in West of Scotland men (Lowe et al, 2000), show that a major part of this association is due to the mutual associations of blood viscosity and its determinants, baseline evidence of CVD, cardiovascular risk factors and risk of death.…”

Section: Discussionmentioning

confidence: 99%

“…Only two recent studies have reported on the association of viscosity with total mortality. Koenig et al (2000) reported a significant, independent association of plasma viscosity (whole blood viscosity was not measured) with mortality in the prospective Augsburg MONICA cohort. Lowe et al (2000) reported a significant association of calculated whole-blood viscosity with mortality in the West of Scotland Coronary Prevention Study; however, only fibrinogen remained associated with mortality after adjustment for baseline CVD and classic cardiovascular risk factors.…”

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confidence: 99%

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Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland

et al. 2003

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Summary. There is increasing evidence that blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen) are associated with an increased risk of incident cardiovascular events; however, their associations with mortality are not established. We therefore studied the associations of these variables with cardiovascular events and total mortality in 1238 men and women aged 25-64 years, followed for 13 years in the first North Glasgow MONICA (MONItoring CArdiovascular disease) survey and West of Scotland centres in the Scottish Heart Health Study. After adjustment for age and sex, increasing whole blood viscosity, plasma viscosity, haematocrit and fibrinogen (analysed by both von Clauss and heat precipitation assays) were significantly associated with mortality. Only the association for fibrinogen (von Clauss assay) remained significant after adjustment for major cardiovascular risk factors. We conclude that clottable fibrinogen may be independently associated with mortality. However, the significance of this association, and the extent to which viscosity is associated with mortality, remain to be established in larger studies and meta-analyses.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland

et al. 2003

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“…Therefore plasma viscosity, in addition to intraluminal pressure and flow pattern, is a major determinant of endothelial shear stress in this particular region. Plasma viscosity is used as a marker for different diseases in humans such as coronary artery disease (Koenig et al 2000;Lowe et al 2000), lupus erythematosus (Reid & DeCeulaer, 1999;Rosenson et al 2001) and rheumatoid arthritis (Grassi et al 1998). However, an increase in plasma viscosity with the progression of disease (Hoffmeister et al 2001) or with therapy (Gibbs et al 2001) was not observed.…”

Section: Differences In Plasma Viscositymentioning

confidence: 97%

Whole Blood Viscosity, Plasma Viscosity and Erythrocyte Aggregation in Nine Mammalian Species: Reference Values and Comparison of Data

Windberger

Bartholovitsch

Plasenzotti

et al. 2003

Experimental Physiology

288

174

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In this study species-specific values for whole blood viscosity (WBV), plasma viscosity (PV) and erythrocyte aggregation (EA) were determined in a total of 360 animals. We used 40 individual adult animals of nine mammalian species: horse, pig, dog, cat, rat, cattle, sheep, rabbit and mouse. WBV measurements were carried out using a LS30 viscometer, PV was measured using OCR-D and EA was measured using a Myrenne aggregometer and the LS30 (aggregation index at low shear rate). At low shear rates (0.7 s _1 and 2.4 s _1 ) haematocrit (Hct)-standardized (40 % Hct) samples showed a higher value of WBV and EA in horse, pig, dog and cat. In cattle, sheep, rabbit and mouse, EA and WBV were markedly decreased and EA was almost undetectable, although the plasma fibrinogen concentration was higher in these animals. Rats showed the highest WBV at low shear rate in native blood and WBV was not different from horse in Hct-standardized blood; however, EA was very low in the rat, a result that might be explained by mechanical or geometrical properties of the red blood cell. EA correlated with the plasma protein concentration in each species except dog and mouse. In horse, cattle and pig, EA correlated with the plasma fibrinogen concentration. At high shear rate (94 s _1 ), WBV was higher in cattle than cat and rat, and dog had higher values than horse, suggesting specific interspecies differences depending on low shear and high shear values of WBV, as a result of mechanisms that influence RBC flexibility. PV was highest in cattle and lowest in rabbit and mouse and did not correlate with WBV. Haemorheological parameters differed between the species. Each species has its own rheological fingerprint. The physiological significance of these variations among mammalian species has not yet been established. Viscosity contributes to endothelial cell shear stress. While haemorheological parameters differ across the species it may be postulated that factors influencing flow-mediated endothelial cell signal transduction are different among the species. Experimental Physiology (2003) 88.3, 431-440. 2496 Publication of The Physiological Society

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“…In addition, we prospectively analyzed the association between plasma viscosity and total mortality in the same cohort and found a RR to die of 2.68 (95 % CI, 1.63 -4.42) in subjects being in the top quintile of the plasma viscosity distribution compared to the bottom quintile [13].…”

Section: Plasma Viscositymentioning

confidence: 99%

Systemic Low-Grade Inflammation and Risk of Coronary Heart Disease: Results from the MONICA/KORA Augsburg Cohort Studies

Köenig¹,

Meisinger²,

Baumert³

et al. 2005

Gesundheitswesen

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Atherosclerosis is characterised by a non-specific local inflammatory process accompanied by a systemic response. A number of prospective studies in initially healthy subjects and in patients with manifest atherosclerosis have now convincingly demonstrated a strong and independent association between even slightly elevated concentrations of various systemic markers of inflammation (plasma viscosity, C-reactive protein [CRP], and other acute phase reactants) and a number of cardiovascular endpoints. Presently, CRP, the classical acute phase protein, seems to be the marker of choice for the clinical situation. Initial evidence suggests that measurement of CRP adds to global risk assessment based on the Framingham risk score. The recent AHA/CDC consensus report recommends the measurement of CRP in asymptomatic subjects at intermediate risk for future coronary events (10-year risk of 10 -20 %) and in selected patients after an acute coronary syndrome. Whether CRP shall alter treatment strategies in subjects without clinically manifest atherosclerosis is presently being tested in a large randomised clinical trial. In addition, recent research has suggested that CRP may not only be a risk marker, but may be directly involved in the pathogenesis of atherothrombosis. However, there are other emerging biomarkers. Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ), an enzyme produced by monocytes/macrophages, T-cells and mast cells was found to generate proinflammatory and proatherogenic molecules from oxidised LDL. We tested the association of these new biomarkers with traditional risk factors Übersicht S62This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.

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Association between plasma viscosity and all‐cause mortality: results from the MONICA–Augsburg Cohort Study 1984–92

Cited by 37 publications

References 36 publications

Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland

Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland

Whole Blood Viscosity, Plasma Viscosity and Erythrocyte Aggregation in Nine Mammalian Species: Reference Values and Comparison of Data

Systemic Low-Grade Inflammation and Risk of Coronary Heart Disease: Results from the MONICA/KORA Augsburg Cohort Studies

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