Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study

Yuan, Hong; Zhou, Ziyi; Zhang, Nan; He, Qiong; Guo, Zhangyou; Liu, Lishun; Song, Yun; Chen, Ping; Wei, Yaping; Xu, Qiuyue; Li, Ya; Zhang, Yuanyuan; Qin, Xianhui; Xu, Xiping; Duan, Yong

doi:10.1111/jch.14516

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…Despite all mice receiving the same diet, we observed notably higher levels of antioxidants and anti-inflammatory compounds in shamF compared to shamM. These compounds, likely derive from food intake, included carnosic acid [19], arachidonic acid [20], choline [21], nicotinamide [22], D-pantothenic acid [23], gamma-crocetin [24], ruscogenin [25], 4-hydroxycinnamic acid [26], oleamide [27, 28] ( Figure 3C). Conversely, shamM mice exhibited elevated levels of metabolites associated with resistance to high-fat diet-related diseases, such as 5-HEPE [29] and 12-HEPE [30], and a higher level of protective L-Anserine [31] than shamF ( Figure 3C) .…”

Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Sex-related Serum Metabolomic Featuresmentioning

confidence: 99%

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Castration Model Illuminates Sex Differences in Healthy Aging: Insights from Metabolome and Transcriptome Analyses

Jiang,

Ge,

Wang

et al. 2023

Preprint

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Females typically outlive males, a disparity mitigated by castration, yet the molecular underpinnings remain elusive. Our study leverages untargeted metabolomics and RNA sequencing to uncover the pivotal compounds and genes influencing healthy aging post-castration, examining serum, kidney, and liver biospecimens from 12-week and 18-month old castrated male mice and their unaltered counterparts. Behavioral tests and LC-MS/MS metabolomics reveal that castrated males exhibit altered steroid hormones, superior cognitive performance, and higher levels of anti-oxidative compounds like taurine, despite identical diets. Integrated metabolome-transcriptome analysis confirms reduced lipid peroxidation and oxidative stress in female and castrated male mice, suggesting a protective mechanism against aging. Histological examinations post- cisplatin treatment highlight the model’s applicability in studying drug toxicity and reveal varying susceptibility in organ-specific toxicities, underlining the crucial role of sex hormones in physiological defenses. In essence, our castration model unveils a feminized metabolic and transcriptomic intermediary, serving as a robust tool for studying gender-specific aspects of healthy aging and exploring sex hormone-induced differences in diverse biomedical domains.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Sex-related Serum Metabolomic Featuresmentioning

confidence: 99%

Castration Model Illuminates Sex Differences in Healthy Aging: Insights from Metabolome and Transcriptome Analyses

Jiang,

Ge,

Wang

et al. 2023

Preprint

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“…According to current literature, the increased circulating levels of B5 should be correlated with a good state of health that is reflected in effective immune responses (63,68). Moreover,…”

Section: B5 Vitamin (Pantothenic Acid)mentioning

confidence: 97%

“…According to current literature, the increased circulating levels of B5 should be correlated with a good state of health that is reflected in effective immune responses ( 63 , 68 ). Moreover, by increasing the level of SOD in the lungs and inhibiting the accumulation of neutrophils, B5 derivatives significantly attenuate pulmonary edema ( 69 ) ( Figure 3 ).…”

Section: Water-soluble Vitaminsmentioning

confidence: 99%

E, K, B5, B6, and B9 vitamins and their specific immunological effects evaluated by flow cytometry

et al. 2023

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It has been proven that vitamins play an essential role in preventing certain diseases since ancient times. It is thus fruitless to approach the roles of vitamins without making reference to the techniques used in evaluating the effects of these micronutrients. Therefore, the aim of this paper was to summarize the immunological effects of E, K, B5, B6, and B9 vitamins evaluated by flow cytometry. Some of these significant effects were presented and discussed: (a) The role of vitamins E in the prevention and treatment of different types of cancer. (b) The properties of K vitamins in the development and maintenance of pheochromocytoma Cell Line 12 (PC12) cells in Parkinson’s disease; (c) The improvement effect of vitamin B5 on the loss of bone mass in low estrogen conditions; (d) The anticancer role of vitamins B6. (e) The role of Vitamin B9 in the regulation of Treg cells. As such, the flow cytometry technique used to assess these properties is essential to evaluate the immunomodulatory effects of certain vitamins. The technique undergoes constant improvement which makes it possible to determine several parameters with a role in the modulation of the immune function and at the same time increase the accuracy of the methods that highlight them.

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“…On the other hand, greater baseline levels of plasma VB5 are associated with an increased risk of all-cause death in Chinese patients with hypertension, particularly in older adults and those with sufficient folate levels. If the findings are validated, they could influence the development of new therapeutic and dietary recommendations as well as therapies that would maximize VB5 levels [ 157 ]. Furthermore, a 12-month prospective investigation discovered a strong correlation between higher VB5 intake and higher rates of genome damage, a biomarker for a higher risk of cancer [ 80 ] ( Table 2 ).…”

Section: Pantothenic Acid/vb5 Bioavailability Dose and Efficiencymentioning

confidence: 99%

B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency

Munteanu,

Schwartz

2023

Nutrients

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The present review deals with two main ingredients of energy/power drinks: B vitamins and glucuronolactone and their possible effect on the immune system. There is a strong relationship between the recommended daily dose of selected B vitamins and a functional immune system. Regarding specific B vitamins: (1) Riboflavin is necessary for the optimization of reactive oxygen species (ROS) in the fight against bacterial infections caused by Staphylococcus aureus and Listeria monocytogenes. (2) Niacin administered within normal doses to obese rats can change the phenotype of skeletal fibers, and thereby affect muscle metabolism. This metabolic phenotype induced by niacin treatment is also confirmed by stimulation of the expression of genes involved in the metabolism of free fatty acids (FFAs) and oxidative phosphorylation at this level. (3) Vitamin B5 effects depend primarily on the dose, thus large doses can cause diarrhea or functional disorders of the digestive tract whereas normal levels are effective in wound healing, liver detoxification, and joint health support. (4) High vitamin B6 concentrations (>2000 mg per day) have been shown to exert a significant negative impact on the dorsal root ganglia. Whereas, at doses of approximately 70 ng/mL, sensory symptoms were reported in 80% of cases. (5) Chronic increases in vitamin B12 have been associated with the increased incidence of solid cancers. Additionally, glucuronolactone, whose effects are not well known, represents a controversial compound. (6) Supplementing with D-glucarates, such as glucuronolactone, may help the body’s natural defense system function better to inhibit different tumor promoters and carcinogens and their consequences. Cumulatively, the present review aims to evaluate the relationship between the selected B vitamins group, glucuronolactone, and the immune system and their associations to bioavailability, doses, and efficiency.

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Association between plasma Vitamin B5 levels and all‐cause mortality: A nested case‐control study

Cited by 5 publications

References 31 publications

Castration Model Illuminates Sex Differences in Healthy Aging: Insights from Metabolome and Transcriptome Analyses

Castration Model Illuminates Sex Differences in Healthy Aging: Insights from Metabolome and Transcriptome Analyses

E, K, B5, B6, and B9 vitamins and their specific immunological effects evaluated by flow cytometry

B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency

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