Association between Platelet Count and Admission of Intensive Care Unit in Maternal Sepsis

Abstract

Background: Maternal sepsis is a major cause of gestational morbidity worldwide. Due to physiological adjustment after pregnancy, it is challenging to identify whether there is association between platelet count (PLT/PC) and severity of maternal sepsis. Therefore, we aimed to find out the correlation between PLT/PC and Intensive Care Unit (ICU) admission and risk threshold of PLT/PC in maternal sepsis while deterioration. Methods: We retrospectively distinguished 144 patients who were diagnosed as maternal sepsis in Third Affiliated Hospital of Guangzhou Medical University from September 4, 2018, to May 11, 2022. Information about demographic, laboratory, maternal and fetal outcome were collected through electronic medical record system in our hospital. Subjects were divided into three groups according to PLT/PC. To compare outcomes between them, a multivariate logistic regression analysis was conducted. Results: There were 20.8% (30/144) patients whose PLT/PC was ≤100 (×109/L), 83.3% of them (25/30) were admitted into ICU. 51.4% (74/144) of subjects had a PLT/PC of 100-200 (×109/L), 62.2% (42/74) of them gained the admission of ICU. After adjusting for confounders, in the PLT/PC of ≤100 group, the odd of admission into ICU was more 16.8 times than in the reference group (PLT/PC of 100-200) (p＜0.05). Conclusions: We should be warned whether there were deterioration when the PLT/PC was ＜100×109/L in maternal sepsis.