Association Between Platelet Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis: Cross-Sectional Study

Furukawa, Shinya; Yagi, Sen; Shiraishi, Kana; Mori, Kenichirou; Nakamura, Tomoyuki; Kawasaki, Keitarou; Mizukami, Yuji; Suzuki, Seiyuu; Uraoka, Masayoshi; Shibata, Naozumi; Nakamura, Sanae; Imamine, Satoshi; Murakami, Hidehiro; Ohashi, Katsuhisa; Torisu, Masamoto; Hasebe, Aki; Yano, Harumi; Murakami, Masato; Takeshita, Eiji; Ikeda, Yoshio; Hiasa, Yoichi

doi:10.21203/rs.3.rs-60855/v1

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…According to the calculated maximum Youden index, the cut-offs for SDNN, SDSD and RMSSD should be 16.807ms, 14.721ms, 15.516ms and 77.5beats/min, respectively. Cut-offs for other quantitative variables were decided using either commonly used or previously published clinical references [8,9]. The accuracy, sensitivity and speci city for our model was 89.0%, 84.4% and 91.5%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Lower ultra-short-term heart rate variability is a risk factor for worse mucosal healing in ulcerative colitis

Guo

Chen

Zhu

et al. 2022

Preprint

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Background Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychological scales are time-consuming and the results may not be comparable among patients with different educational levels and cultural backgrounds. Alternatively, heart rate variability (HRV) is an indicator for psychological stress and not biased by educational and cultural backgrounds. Aims In this study, we try to explore the relationship between psychological stress and UC by analyzing the effect of ultra-short-term HRV on mucosal and histological remission status of UC. Methods This is a retrospective case-control study on UC inpatients from 2018 through 2020. Ultra-short-term HRV were calculated using baseline electrocardiography. Patients were divided into case and control groups according to their Mayo endoscopic scores or histological Geboes scores. Three variables of ultra-short-term HRV (SDNN, SDSD and RMSSD) were compared between different groups. And for those variables with significant differences, we built univariate and multivariate logistic regressions to depict the relationship between HRV variables and remission status of UC. Results All three HRV variables showed significant differences between the mucosal groups. However, none of them showed significant difference between the histological groups. In further logistic regression analyses, smaller RMSSD was detected as a risk factor for severe mucosal healing status (OR = 5.21). Conclusions Lower ultra-short-term HRV (i.e. smaller RMSSD) is shown to correlate with worse mucosal healing status. However, ultra-short-term HRV cannot predict histological healing status according to our data.

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Section: Resultsmentioning

confidence: 99%

Lower ultra-short-term heart rate variability is a risk factor for worse mucosal healing in ulcerative colitis

Guo

Chen

Zhu

et al. 2022

Preprint

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“…Эта модель прогнозирования риска предлагает объективный инструмент для правильного принятия клинических решений [3]. Повышенное количество тромбоцитов, по мнению Furukawa S. et al [4] увеличивает риск рецидива у пациентов с язвенным колитом, что, по их мнению, может быть использовано как важный прогностический тест. Созвучно с данной точкой зрения и применительно к другим заболеваниям многие авторы видят в факторах риска, тем более в сочетании их наличия прогностические свидетельства возникновения или рецидивов заболеваний.…”

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Methodology and algorithms for the formation of prognostic decisions in gastroenterology on the example of ulcerative colitis

Baranovsky

2022

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The creation of a system for predicting the nature of the course of the acute phase of ulcerative colitis (UC) would be able to block possible complications and other life-threatening variants of the development of the pathological process with timely preventive therapy. The purpose of the study. To formulate an effective methodology and create effective decisive rules for predicting the nature of the course of diseases of the digestive system in the phase of acute phenomena of the pathological process on the example of UC for justification based on the prognostic conclusion of the volume, content and intensity of individual therapy. Material, methods and results of the study. 366 patients with UC were examined (men - 213, women - 153). Age of patients: from 18 to 78 years. Patients with distal colitis - 211, with left-sided colitis - 68, with subtotal - 66, with total - 21. Acute course of UC occurred in 167 patients. All other 199 patients had a relapse of the chronic course of UC. At the same time, 140 patients had a rare recurrence of the disease, and 59 patients often had a recurrent course. We observed a chronic continuously recurrent course of UC in 14 patients out of 59 patients. The use of mathematical forecasting methods in the form of an inhomogeneous sequential procedure, discriminant and cluster analyses used in the construction of the prognostic program made it possible to identify from a large number of clinical signs of UC 28 the most significant symptoms of the acute phase of the disease for prognosis and to give them an appropriate quantitative characteristic. The developed computer program, which individually summarizes the prognostic coefficients of each patient, provides the clinician with information about the degree of risk of developing an “unfavorable” course of the disease (complications, hormonal resistance, hormonal dependence, extra-intestinal manifestations, etc.) or assumes a “favorable” course of UC: a rapid adequate response of the body to standard therapeutic measures. Conclusion. The materials of the article allow us to accurately predict the course of UC in the acute phase of the disease, which can serve as a methodological and methodological basis for further progressive scientific movement in solving more significant and global problems in gastroenterology

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Association Between Platelet Count and Mucosal Healing in Japanese Patients With Ulcerative Colitis: Cross-Sectional Study

Cited by 2 publications

References 6 publications

Lower ultra-short-term heart rate variability is a risk factor for worse mucosal healing in ulcerative colitis

Lower ultra-short-term heart rate variability is a risk factor for worse mucosal healing in ulcerative colitis

Methodology and algorithms for the formation of prognostic decisions in gastroenterology on the example of ulcerative colitis

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