Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis

Zhang, W.; Zhang, L.C.; Chen, H.; Tang, Peifu

doi:10.4238/2015.july.13.10

Cited by 10 publications

(17 citation statements)

References 18 publications

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“…All of the studies were published in English. A total of 2807 participants took part in the studies, with 1 recruiting men and women, [ 25 ] and 3 women only. [ 23 , 24 , 26 ] Four studies investigated rs35767, [ 23 – 26 ] 3 studies assessed rs2288377, [ 23 – 25 ] and 3 studies evaluated rs5742612.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 2807 participants took part in the studies, with 1 recruiting men and women, [ 25 ] and 3 women only. [ 23 , 24 , 26 ] Four studies investigated rs35767, [ 23 – 26 ] 3 studies assessed rs2288377, [ 23 – 25 ] and 3 studies evaluated rs5742612. [ 23 – 25 ] The pooled minor allele frequency for rs35767, rs2288377, rs5742612 was 0.291 (95% CI: 0.275–0.308), 0.100 (95% CI: 0.088–0.113), and 0.131 (95% CI: 0.118–0.146), respectively.…”

Section: Resultsmentioning

confidence: 99%

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Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk

Chen

Zhang²,

Li³

et al. 2017

Medicine

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Background:Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization. We aimed to perform a meta-analysis to assess the association of three IGF-1 single nucleotide polymorphisms (SNPs) rs35767, rs2288377, and rs5742612 with osteoporosis risk.Methods:A systematic search of PubMed, Web of Science, Embase, Medline, Scopus, CNKI, and Wanfang databases was conducted. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using a fixed effects model.Results:Four Chinese case-control studies with a total of 2807 participants were included in this meta-analysis. The results revealed an association between rs35767 and osteoporosis risk in all study subjects (women and men) in dominant (OR 1.32, 95% CI 1.13–1.53, P < .001), recessive (OR 1.73, 95% CI 1.35–2.21, P < .001), homozygote (OR 1.89, 95% CI 1.46–2.45, P < .001), and allelic (OR 1.31, 95% CI 1.18–1.47, P < .001) models. Subgroup analysis according to gender showed that rs35767 was associated with osteoporosis risk in women under dominant (OR 1.29, 95% CI 1.08–1.54, P = .005), recessive (OR 1.59, 95% CI 1.19–2.12, P = .002), homozygote (OR 1.73, 95% CI 1.28–2.34, P < .001), and allelic (OR 1.28, 95% CI 1.12–1.47, P < .001) models. Meta-analysis did not find associations of rs2288377 and rs5742612 with osteoporosis risk. There was no evidence of between-study heterogeneity and publication bias.Conclusion:Our results suggest that rs35767 is associated with osteoporosis risk in Chinese, whereas there is no association of rs2288377 and rs5742612 with osteoporosis risk.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk

Chen

Zhang²,

Li³

et al. 2017

Medicine

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“…Uthra et al . investigated the role of cytosine-adenine (CA) [ 17 , 18 ] repeats in IGF1 promoter region in DR development based on a Southern Indian cohort. The study showed that CA [ 18 ] repeats genotype was a risk factor of DR [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, single nucleotide polymorphism (SNP) has become an important mean of revealing the susceptibility of individuals to some diseases. IGF1 protein encoded gene, IGF1 is located on chromosome 12q22-23 [ 16 ] and consisted of 5 exons and 4 introns, including a number of SNPs [ 17 , 18 ]. However, few studies referred to the association between IGF1 SNPs and DR occurrence.…”

Section: Introductionmentioning

confidence: 99%

IGF1gene polymorphisms associated with diabetic retinopathy risk in Chinese Han population

et al. 2017

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ObjectiveThis study aimed to explore the association of insulin-like growth factor 1 gene (IGF1) polymorphisms with diabetic retinopathy (DR) in a Chinese Han population.MethodsPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Genotype frequencies were compared by chi-square test. Odds ratio (OR) with 95% confidence interval (95%CI) was calculated to express the risk intensity of DR. Linkage disequilibrium between IGF1 polymorphisms was analyzed by Haploview. Serum IGF1 concentration was measured by enzyme-linked immunosorbent assays (ELISA) and assessed by student's t test.ResultsAG genotype of rs6218 and TT genotype of rs35767 were significantly associated with the elevated risk of DR (rs6218: OR=1.77, P=0.04; rs35767: OR=2.32, P=0.03) and type II diabetes mellitus (T2DM) (rs6218: OR=1.92, P=0.00. rs35767: OR=2.29, P=0.02). Only T allele of rs35767 significantly increased the risk of DR (OR=1.45, P=0.04), however, rs6218 (OR=1.92, P=0.00), rs35767 (OR=0.02, P=0.02) and rs5742612 (OR=2.21, P=0.04) showed obvious association with T2DM. Haplotypes were only associated with T2DM, but not DR. Minor allele homozygote of rs35767 was obviously correlated with serum IGF1 level.ConclusionIGF1 rs6218 and rs35767 polymorphisms contribute to the risk of DR. IGF1 rs35767 polymorphism may participate in the regulation of serum IGF1 concentration in DR.

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“…The effect of IGF-I deficiency has been confirmed in humans, in which patients with a mutant IGF-IR show growth retardation both before and after birth, and a mutant IGF-I gene can lead to significantly decreased BMD (Camacho-Hübner et al, 2002; Walenkamp et al, 2005; Walenkamp and Wit, 2007). Furthermore, a recent study showed a significant association between polymorphisms in the IGF-I gene and risk of osteoporosis in a population of Chinese women (Zhang et al, 2015). Thus, both GH and IGF-I are key regulators of peak bone mass acquisition in animals and in humans.…”

Section: Gh/igf Effects On Bonementioning

confidence: 99%

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Lindsey

Mohan

2016

Molecular and Cellular Endocrinology

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The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the regulation of bone formation, and deficiencies in this system have been shown to contribute to the development of osteoporosis and other diseases of low bone mass. The GH/IGF axis is regulated by a complex set of hormonal and local factors which can act to regulate this system at the level of the ligands, receptors, IGF binding proteins (IGFBPs), or IGFBP proteases. A combination of in vitro studies, transgenic animal models, and clinical human investigations has provided ample evidence of the importance of the endocrine and local actions of both GH and IGF-I, the two major components of the GH/IGF axis, in skeletal growth and maintenance. GH- and IGF-based therapies provide a useful avenue of approach for the prevention and treatment of diseases such as osteoporosis.

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Association between polymorphisms in insulin-like growth factor-1 and risk of osteoporosis

Cited by 10 publications

References 18 publications

Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk

Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk

IGF1gene polymorphisms associated with diabetic retinopathy risk in Chinese Han population

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

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