Association between polymorphisms in interleukin-18 promoter and risk of coronary artery disease: a meta-analysis

Zheng, Liduan; Li, Sufang; Cui, Yuxia; Wu, Mingxin; Su, Li-Na; Hu, Dan; Xiong, Wei-Jue; Chen, Hong

doi:10.1042/bsr20192721

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…For -607C/A, the overall OR related with a decreased risk of CAD in different genetic models including allelic (OR=0.8), recessive (OR=0.7) dominant (OR=0.7), homozygous (OR=0.6), and heterozygous models (OR=0.7). Additionally, IL-18 polymorphisms were associated with MI and multivessel (MV) disease [ 143 ]. Overall, genetic variation of the IL-18 can regulate the production of IL-18 and could potentially predict future coronary events.…”

Section: Genetic Evidencementioning

confidence: 99%

The Role of Interleukin-18 in the Development and Progression of Atherosclerosis

Bahrami

Sathyapalan

Sahebkar

2021

CMC

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: Atherosclerosis (AS) as a chronic inflammatory disorder of the cardiovascular system, is one of the leading cause of ischemic heart disease, stroke and peripheral vascular disease. There is growing evidence on the role of innate and adaptive immunity in the pathogenesis of atherosclerosis. Interleukin-18 is one of the novel proinflammatory cytokines involved in the atherogenesis, atherosclerotic plaque instability and plaque rupture. In this review, we overview the findings of the preclinical and clinical studies about the role and mechanism of action of IL-18 in the pathogenesis of AS, which could offer novel prognostic and therapeutic approaches.

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Section: Genetic Evidencementioning

confidence: 99%

The Role of Interleukin-18 in the Development and Progression of Atherosclerosis

Bahrami

Sathyapalan

Sahebkar

2021

CMC

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“…Also, a meta-analysis of 15 studies published by Lian et al, suggested that the -137 polymorphism and the -607 polymorphism in the IL-18 promoter were associated with CAD and its consequences. [ 29 ] The information presented by Tiret et al [ 28 ] in 2005 is confirmed by the analysis of the data.…”

Section: Discussionmentioning

confidence: 59%

Identification of Risk Genes Associated with Myocardial Infarction—Big Data Analysis and Literature Review

Tirdea

Hostiuc

Moldovan

et al. 2022

IJMS

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Acute myocardial infarction occurs when blood supply to a particular coronary artery is cut off, causing ischemia or hypoxia and subsequent heart muscle destruction in the vascularized area. With a mortality rate of 17% per year, myocardial infarction (MI) is still one of the top causes of death globally. Numerous studies have been done to identify the genetic risk factors for myocardial infarction, as a positive family history of heart disease is one of the most potent cardiovascular risk factors. The goal of this review is to compile all the information currently accessible in the literature on the genes associated with AMI. We performed a big data analysis of genes associated with acute myocardial infarction, using the following keywords: “myocardial infarction”, “genes”, “involvement”, “association”, and “risk”. The analysis was done using PubMed, Scopus, and Web of Science. Data from the title, abstract, and keywords were exported as text files and imported into an Excel spreadsheet. Its analysis was carried out using the VOSviewer v. 1.6.18 software. Our analysis found 28 genes which are mostly likely associated with an increased risk for AMI, including: PAI-1, CX37, IL18, and others. Also, a correlation was made between the results obtained in the big data analysis and the results of the review. The most important genes increasing the risk for AMI are lymphotoxin-a gene (LTA), LGALS2, LDLR, and APOA5. A deeper understanding of the underlying functional genomic circuits may present new opportunities for research in the future.

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“…In addition to RA predisposition, increasing evidence on the association between IL-18 polymorphisms and other disease conditions has also been reported by systematic reviews and meta-analyses. The -607 C/A and/or -137 G/C polymorphisms in IL-18 may confer susceptibility to tuberculosis, especially in Asians [33]; inflammatory bowel disease, including both Crohn's disease and ulcerative colitis in Asians and Africans [34][35][36]; vasculitis [37] and systemic lupus erythematosus in Europeans and Asians [38]; Behcet's disease [39], various types of liver diseases [40,41], hepatitis B virus in East Asians and hepatitis C virus infection in South Asians [42] and Asian populations [43]; diabetic nephropathy in Asians [44]; allergic asthma and allergic dermatitis [45][46][47], Alzheimer's disease in Asians [48,49]; periodontitis [50], coronary artery disease in East Asians [51,52]; head and neck cancer risk, especially nasopharyngeal cancer, in Asian populations [53]; breast cancer in East Asians from China [54,55]; and prostate cancer in Asian and Caucasian populations [56]. IL-18 has been reported to be a potential clinical biomarker.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses

Chen,

Ye,

Liu

et al. 2024

Journal of Immunology Research

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This study systematically analyzes the association between interleukin-18 (IL-18) gene polymorphisms and rheumatoid arthritis (RA) susceptibility. The electronic databases Ovid MEDLINE, Ovid Excerpta Medica Database, and Cochrane Library were searched to identify meta-analyses that included case–control studies reporting IL-18 gene polymorphisms and RA susceptibility. Data were reanalyzed using Review Manager Software 5.1, and Mantel–Haenszel random effects were applied for the five genetic models: allelic, recessive, dominant, homozygote, and heterozygote. The effect size of odds ratios (ORs) and their corresponding 95% confidence interval (CI) were calculated. A total of seven meta-analyses with poor quality were included. The IL-18 polymorphisms -607 A/C, -137 C/G, -920 T/C, and -105 C/A have been reported. With weak evidence, IL-18 -607 A/C polymorphisms were associated with a reduced risk of RA susceptibility using the allele model (OR = 0.76, 95% CI: 0.61 − 0.93, p=0.01), dominant model (OR = 0.67, 95% CI: 0.50 − 0.90, p=0.008), homozygote model (OR = 0.57, 95% CI: 0.35 − 0.91, p=0.02), and heterozygote model (OR = 0.71, 95% CI: 0.54 − 0.93, p=0.01) in the overall population. IL-18 gene polymorphisms and RA susceptibility are affected by ethnicity: With weak evidence, IL-18 -137 C/G polymorphisms were related to reduce RA susceptibility in the Asian population (allele model: OR = 0.59, 95% CI: 0.40 − 0.88, p=0.01; dominant model: OR = 0.57, 95% CI: 0.37 − 0.89, p=0.01; heterozygote model: OR = 0.60, 95% CI: 0.38 − 0.94, p=0.03). IL-18 -607 A/C gene polymorphisms are a protective factor for RA susceptibility in the overall population, and IL-18 −137 C/G gene polymorphisms are a protective factor for RA susceptibility in the Asian population. Further studies are needed to confirm these results owing to the limitations of the included studies.

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Association between polymorphisms in interleukin-18 promoter and risk of coronary artery disease: a meta-analysis

Cited by 12 publications

References 34 publications

The Role of Interleukin-18 in the Development and Progression of Atherosclerosis

The Role of Interleukin-18 in the Development and Progression of Atherosclerosis

Identification of Risk Genes Associated with Myocardial Infarction—Big Data Analysis and Literature Review

Interleukin-18 Gene Polymorphisms and Rheumatoid Arthritis Susceptibility: An Umbrella Review of Meta-Analyses

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