Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Abstract

Background: Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. Methods: The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships. Results: There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891. Conclusions: Our current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.

Potential Genes Associated with COVID-19 and Comorbidity

“…MBL2 encodes a vital molecule in the innate immune system, a soluble mannose-binding lectin. An MBL2 deficiency is related to the susceptibility of infectious diseases 77 . The MBL2 variant rs5030737 is positively correlated with the number of COVID-19 cases but not with the number of deaths.…”

Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection

“…The basic structural subunit of MBL is a homotrimer of MBL polypeptides, entwined in a triple helix. Each single polypeptide chain has four domains: (1) a 21-amino acid N-terminal cysteine-rich region involved in oligomerization, (2) a 59-amino acid collagen-like domain, (3) a 30-amino acid α -helical, hydrophobic coiled-coil neck domain, which is crucial for initiating the oligomerization, and (4) a 188-amino acid C-terminal carbohydrate recognition domain ( Shen et al, 2020 ). The homozygous mutation, i.e., BB, results in the overall absence of the MBL2 protein, whereas heterozygous mutation; i.e., AB, results in a 5 to 10-fold reduction in serum MBL2 protein level when compared to the wild type, i.e., AA.…”

The influence of single nucleotide polymorphisms of NOD2 or CD14 on the risk of Mycobacterium tuberculosis diseases: a systematic review

“…The molecular basis of immune response to infectious diseases is an indispensable approach to understand how gene regulation ultimately may impact clinical outcomes. In recent decades, a great deal of research has sought to identify associations between genetic polymorphisms and risk of Mtb diseases [36,37]. Most of the target loci are PRRs contributing to control of mycobacterial diseases, especially TB [38].…”