Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows

Polymorphism of insulin-like growth factor 1 gene and its relationship with reproductive performances and milk yield in Sarda dairy sheep

“…Nucleotide variations at the 5′ UTR of the IGF-I gene were also found in cattle and had been correlated with reproductive traits ( Mullen et al., 2011 ; Nicolini, Carriquiry & Meikle, 2013 ). Also, in other animals’ species a positive effect of some polymorphisms of the IGF-I gene on reproductive activity has been found and many times this effect has been linked to the type of animal management ( Hax et al., 2017 ). The important role of IGF-I hormone has been recognized in several reproductive stages, in fact, the higher levels of this hormone in pregnancy are necessary for fetal development and in postpartum favor the recovery of ovarian function ( Kawashima et al., 2006 ; Satue, Marcilla, Medica, Cravana & Fazio, 2018 ).…”

Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico

“…This approach may have resulted in the discounting of embryonic mortality which occurs at a high rate prior to 45 gestational days (Diskin et al, 2016), thereby masking the effect of the polymorphism. Conversely, Shirasuna et al (2011) and Hax et al (2017) found lesser CFHIs in cows with allele G of the STAT5A polymorphism. The effect of this allele may be due to the gene's role in the growth hormone signaling pathway, as STAT proteins are activated specifically to regulate gene transcription, increasing the insulin-like growth factor 1 level.…”

“…Conversely, Shirasuna et al. (2011) and Hax et al. (2017) found lesser CFHIs in cows with allele G of the STAT5A polymorphism.…”

“…Ortega et al (2016) reported similar frequencies of 0.49 for allele A and 0.51 for allele G. For the STAT5A polymorphism, the frequencies of allele C and G were 0.58 and 0.42, respectively. Shirasuna et al (2011) reported frequencies of 0.56 for allele C and 0.44 for allele G and Hax et al (2017) reported frequencies of 0.52 and 0.48, respectively.…”

“… Shirasuna et al. (2011) reported frequencies of 0.56 for allele C and 0.44 for allele G and Hax et al. (2017) reported frequencies of 0.52 and 0.48, respectively.…”