Association Between Postoperative Complications and Clinical Cancer Outcomes

Scaife, Courtney L.; Hartz, Arthur J.; Pappas, Lisa M.; Pelletier, Peter; He, Tao; Glasgow, Robert E.; Mulvihill, Sean J.

doi:10.1245/s10434-013-3267-0

Cited by 22 publications

(11 citation statements)

References 22 publications

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“…Artinyan et al similarly demonstrated that the negative effect of perioperative morbidity on long-term outcomes after CRC resection was largely mediated by infectious complications [19]. In a separate study, Scaife et al queried the NSQIP database for solid malignancies and investigated the relationship of infectious complications with long-term outcomes [22]. The authors noted that infectious complications were associated with over a threefold increased risk of death in the long-term.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long‐Term Survival

et al. 2015

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Background The association of postoperative complications with long-term oncologic outcomes remains unclear. We sought to determine the incidence of complications among patients who underwent surgery for adrenocortical carcinoma (ACC) and define the relationship of morbidity with long-term survival. Methods Patients who underwent surgery for ACC between 1993 and 2014 were identified from 13 academic institutions participating in the US ACC group study. The incidence and type of the postoperative complications, the factors associated with them as well their association with long-term survival were analyzed. Results A total of 265 patients with median age of 52 years (IQR 44–63) were identified; at surgery, the majority of patients underwent an open abdominal procedure (n = 169, 66.8 %). A postoperative complication occurred in 99 patients for a morbidity of 37.4 %; five patients (1.9 %) died in hospital. Factors associated with morbidity included a thoraco-abdominal operative approach (reference: open abdominal; OR 2.85, 95 % CI 1.00–8.18), and a hormonally functional tumor (OR 3.56, 95 % CI 1.65–7.69) (all P < 0.05). Presence of any complication was associated with a worse long-term outcome (median survival: no complication, 58.9 months vs. any complication, 25.1 months; P = 0.009). In multivariate analysis, after adjusting for patient- and disease-related factors postoperative infectious complications independently predicted shorter overall survival (hazard ratio (HR) 5.56, 95 % CI 2.24–13.80; P < 0.001). Conclusion Postoperative complications were independently associated with decreased long-term survival after resection for ACC. The prevention of complications may be important from an oncologic perspective.

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Section: Discussionmentioning

confidence: 99%

Incidence of Perioperative Complications Following Resection of Adrenocortical Carcinoma and Its Association with Long‐Term Survival

et al. 2015

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“…Postoperative complications may result in shorter survival and impaired QoL, and the outcome of surgery depends profoundly on the frequency, severity grade and management of complications. 3 Comprehensive efforts have been made to define and classify severity grade of complications after pancreatic surgery, and the consensus definitions have been widely implemented. 4 However, a need to refine the concepts and redefine specific complications has recently been recognized.…”

Section: Introductionmentioning

confidence: 99%

Survival, Complications and Patient Reported Outcomes after Pancreatic Surgery

Baekelandt

Fagerland

Hjermstad

et al. 2019

HPB

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“…In addition, we found that LC was negatively associated with these delayed recovery issues, including pelvic fluid collections and infections. This adds to the body of literature linking postoperative complications with worse oncologic outcomes in major gastrointestinal surgery .…”

Section: Discussionmentioning

confidence: 90%