Association between pre-diagnostic dietary pattern and survival of ovarian cancer: Evidence from a prospective cohort study

Wen, Zhao-Yan; Liu, Chuan; Liu, Fang-Hua; Wei, Yifan; Xu, He-Li; Wang, Ran; Li, Xinyu; Li, Yi-Zi; Shi, Yan; Qin, Xue; Gao, Song; Li, Xiuqin; Zhao, Yuhong; Gong, Ting-Ting; Wu, Qi‐Jun

doi:10.1016/j.clnu.2021.12.033

Cited by 24 publications

(31 citation statements)

References 42 publications

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“…Thus, it is particularly crucial to find modifiable prognostic factors that can improve the prognosis of OC. Of note, diet is a modifiable factor that could contribute to the improvement of OC survival, which has been verified by our previous research ( 8 – 10 ).…”

Section: Introductionsupporting

confidence: 83%

“…The FFQ was performed by well-trained and skilled researchers through face-to-face interviews. Pre-diagnosis dietary information was measured at baseline through the FFQ, its validity and reliability have been verified by previous studies ( 8 , 9 ). The reproducibility coefficients (Spearman correlation coefficients and intraclass correlation coefficients) were above 0.5 for most food groups, and the correlation coefficients (Spearman correlation coefficients) were between 0.3 and 0.7 for most food groups between the FFQ and weighed dietary records ( 8 – 10 ).…”

Section: Methodsmentioning

confidence: 81%

“…Pre-diagnosis dietary information was measured at baseline through the FFQ, its validity and reliability have been verified by previous studies (8,9). The reproducibility coefficients (Spearman correlation coefficients and intraclass correlation coefficients) were above 0.5 for most food groups, and the correlation coefficients (Spearman correlation coefficients) were between 0.3 and 0.7 for most food groups between the FFQ and weighed dietary records (8)(9)(10). All newly diagnosed OC patients were required to report their usual intake frequency of each food item during the year prior to OC diagnosis, with seven response options: almost never, 2-3 times per month, 1 time per week, 2-3 times per week, 4-6 times per week, 1-2 times per day, and more than two times per day.…”

Section: Dietary Exposure and Assessmentmentioning

confidence: 87%

“…The OOPS is an ongoing ambispective cohort study of newly diagnosed OC patients, designed to assess the associations of demographic and clinical characteristics as well as lifestyle factors with the OC prognosis ( 8 , 23 , 24 ). During the time period between January 2015 and December 2020, 853 newly diagnosed OC patients aged 18–75 years were recruited.…”

Section: Methodsmentioning

confidence: 99%

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Phytosterol intake and overall survival in newly diagnosed ovarian cancer patients: An ambispective cohort study

et al. 2022

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BackgroundPhytosterol is a bioactive compound existing in all plant foods, which might have anticancer properties. The aim of this study was to first assess the impact of the pre-diagnosis phytosterol intake on overall survival (OS) of patients with ovarian cancer (OC).Materials and methodsThis ambispective cohort study recruited 703 newly diagnosed OC patients to investigate the aforementioned associations. Dietary intake was assessed using a validated 111-item food frequency questionnaire. Deaths were ascertained until March 31, 2021, through active follow-up and medical records. Cox proportional hazards regression models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsDuring the median follow-up of 37.17 months, 130 deaths occurred. The median age at diagnosis of 703 OC patients was 53.00 (interquartile: 48.00–60.00) years. Of these, almost half patients (48.08%) were diagnosed in advanced International Federation of Gynecology and Obstetrics (FIGO) stage (III-IV). Additionally, more than half patients were serous carcinoma (68.14%), poorly differentiated (85.21%), and no residual lesions (78.66%). Patients consumed the highest tertile of dietary campesterol (HR = 0.54, 95% CI = 0.31–0.94, P trend < 0.05), stigmasterol (HR = 0.60, 95% CI = 0.37–0.98), and β-sitosterol (HR = 0.63, 95% CI = 0.40–0.99) were significantly associated with better OS compared with those with the lowest tertile of intake. The curvilinear associations were observed between total phytosterols and β-sitosterol intake and OC survival (P non-linear < 0.05). Significant associations were generally consistent across different subgroups stratified by demographical, clinical, and immunohistochemical characteristics. Moreover, there were significant interactions between phytosterol intake and age at diagnosis, body mass index, as well as expressions of Wilms’ tumor-1 and Progestogen Receptor (all P interaction < 0.05).ConclusionPre-diagnosis higher campesterol, stigmasterol, and β-sitosterol intake were associated with better survival among OC patients.

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Section: Introductionsupporting

confidence: 83%

Section: Methodsmentioning

confidence: 81%

Section: Dietary Exposure and Assessmentmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

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Phytosterol intake and overall survival in newly diagnosed ovarian cancer patients: An ambispective cohort study

et al. 2022

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“…The OOPS study has provided results for diet and OC survival (Table 6). For instance, pre-diagnosis healthy pattern was related to better survival, whereas animal foods pattern was associated with worse survival (18); pre-diagnosis dairy product intake was associated with worse survival (19); prediagnosis total cruciferous vegetables and isothiocyanates intake was associated with better survival (20); pre-diagnosis consumption of vitamin B was associated with worse survival (21).…”

Section: Key Publicationsmentioning

confidence: 99%

A Follow-Up Study of Ovarian Cancer (OOPS): A Study Protocol

Gong

Liu

et al. 2022

Front. Nutr.

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The ovarian cancer (OC) follow-up study (OOPS) is an on-going hospital-based large prospective longitudinal cohort study aimed to explore the relationship between pre/post-diagnostic biological, clinical, environmental, and lifestyle factors with focus on the diet and OC prognosis (including drug resistance, relapse, and mortality). Patients recruited during the baseline survey were between 18 and 79 years old, with histologically confirmed OC diagnosis. Their follow-up and medical treatment were conducted at the gynecological oncology ward at Shengjing Hospital of China Medical University, Shenyang, China after 2015. A total of 703 OC patients made up the final OOPS study population. The follow-up stage was conducted in both passive and active modes. In the passive mode, the follow-up was performed by linkage to the Liaoning Providence Center for Disease Control and Prevention every 6 months to obtain health outcome results. The status of lifestyle factors was re-estimated using the same measurements as those in the baseline survey. OC participants in the OOPS study completed a questionnaire and anthropometric examinations. In addition, biological specimens were collected during the baseline survey, which included blood, urine, and stool samples that were stored for further use. This article is intended to serve as an introduction to this project and to provide details for investigators who may be carry out related analysis.

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Diet and Survival in Black Women With Epithelial Ovarian Cancer

Armidie,

Bandera,

Johnson

et al. 2024

JAMA Netw Open

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ImportanceOvarian cancer survival among Black women is the lowest across all racial and ethnic groups. Poor dietary quality also disproportionately affects Black populations, but its association with ovarian cancer survival in this population remains largely unknown.ObjectiveTo examine associations between dietary patterns and survival among Black women diagnosed with epithelial ovarian cancer (EOC).Design, Setting, and ParticipantsThis prospective cohort study was conducted among self-identified Black women aged 20 to 79 years newly diagnosed with histologically confirmed EOC in the African American Cancer Epidemiology Study (AACES) between December 2010 and December 2015, with follow-up until October 2022. AACES is a population-based study of ovarian cancer risk and survival among Black women in 11 US regions. Data were analyzed from March 2023 to June 2024.ExposuresDietary patterns were assessed by the Healthy Eating Index-2020 (HEI-2020) and Alternative Healthy Eating Index-2010 (AHEI-2010), with scores calculated based on dietary intake in the year prior to diagnosis and collected via the validated Block 2005 Food Frequency Questionnaire. Higher scores indicate better dietary quality.Main outcomes and measuresHazard ratios (HRs) and 95% CIs were estimated from multivariable Cox models for the association between adherence to dietary recommendations and overall mortality among all participants and those with high-grade serous ovarian cancer (HGSOC).ResultsAmong 483 Black women with EOC (mean [SD] age, 58.1 [10.5] years), 310 deaths were recorded during a median (IQR) follow-up of 4.3 (2.0-8.2) years. No association of dietary patterns with mortality was found among women with EOC overall. However, among 325 women with HGSOC, better adherence to HEI-2020 was associated with decreased mortality in later quartiles compared with the first quartile (HR, 0.63; 95% CI, 0.44-0.92 for quartile 2; HR, 0.67; 95% CI, 0.46-0.97 for quartile 3; HR, 0.63; 95% CI, 0.44-0.91 for quartile 4 ). Similar results were observed with AHEI-2010 among women with HGSOC for the second (HR, 0.62; 95% CI, 0.43-0.89) and fourth (HR, 0.67; 95% CI, 0.45-0.98) quartiles compared with quartile 1.Conclusions and relevanceIn this study, women with moderate and high prediagnosis dietary quality had significantly lower mortality rates from HGSOC compared with women with the lowest prediagnosis dietary quality. These findings suggest that even moderate adherence to dietary guidelines prior to diagnosis may be associated with improved survival among Black women with HGSOC, the most lethal form of ovarian cancer.

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Association between pre-diagnostic dietary pattern and survival of ovarian cancer: Evidence from a prospective cohort study

Cited by 24 publications

References 42 publications

Phytosterol intake and overall survival in newly diagnosed ovarian cancer patients: An ambispective cohort study

Phytosterol intake and overall survival in newly diagnosed ovarian cancer patients: An ambispective cohort study

A Follow-Up Study of Ovarian Cancer (OOPS): A Study Protocol

Diet and Survival in Black Women With Epithelial Ovarian Cancer

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