Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma

Lorente, Leonardo; Rodriguez, Sergio T; Sanz, Pablo; Abreu-González, Pedro; Díaz, Dácil; Moreno, Antonia Ruíz; Borja, Elisa; Martı́n, Marı́a; Jiménez, Alejandro; Barrera, Manuel

doi:10.3390/ijms17040500

Cited by 24 publications

(16 citation statements)

References 52 publications

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“…Lipid peroxidation can be assessed through the biomarker malondialdehyde (MDA), a major product of lipid peroxidation that can be easily measured in plasma 18 by the chemical methods listed in the second section of table I. Several studies have shown the potential uses of this marker in the anesthesia and intensive care setting.…”

Section: Lipid Peroxidationmentioning

confidence: 99%

Hyperoxia and oxidative stress in anesthesia and critical care medicine

Ottolenghi¹,

Sabbatini²,

Brizzolari³

et al. 2020

Minerva Anestesiol

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Oxygen administration is particularly relevant in patients undergoing surgery under general anesthesia and in those who suffer from acute or critical illness. Nevertheless, excess O2, or hyperoxia, is also known to be harmful. Toxicity arises from the enhanced formation of Reactive Oxygen Species (ROS) that, exceeding the antioxidant defense, may generate oxidative stress. Oxidative stress markers are used to quantify ROS toxicity in clinical and non-clinical settings and represent a promising tool to assess the optimal FiO2 in anesthesia and critical care setting. Despite controversial, the guidelines for the regulation of FiO2 in such settings suggest the adoption of high perioperative oxygen levels. However, hyperoxia has also been shown to be an independent mortality risk factor in critically ill patients. In this literature review, we discuss the biochemical mechanisms behind oxidative stress and the available biomarkers for assessing the pro-oxidant vs antioxidant status. Then, we summarize recent knowledge on the hyperoxia-related consequences in the most common anesthesia and critical care settings, such as traumatic brain injury or cardiac arrest. To this purpose, we searched the Pubmed database according to the following combination of key words: ("hyperoxia" OR "FiO2" OR "oxygen therapy") AND ("oxidative stress" OR "ROS" OR "RNS" OR "lipid peroxidation") AND ("anesthesia" OR "surgery" OR "intensive care"). We focused in the results from the past 20 years. Available evidence points toward a conservative monitoring and use of oxygen, unless there is solid proof of its efficacy.

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Section: Lipid Peroxidationmentioning

confidence: 99%

Hyperoxia and oxidative stress in anesthesia and critical care medicine

Ottolenghi¹,

Sabbatini²,

Brizzolari³

et al. 2020

Minerva Anestesiol

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“…23 Serum TAC levels were analysed in the current study to determine their association with 1-year LT mortality.…”

Section: Methodsmentioning

confidence: 99%

Serum total antioxidant capacity prior to liver transplantation for hepatocellular carcinoma is associated with 1-year liver transplantation survival

et al. 2018

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ObjectiveTo determine whether there was an association between serum total antioxidant capacity (TAC) levels prior to in liver transplantation (LT) for hepatocellular carcinoma (HCC) and 1-year LT mortality.MethodsThis observational retrospective single-centre study of patients with LT for HCC measured serum levels of TAC and malondialdehyde (as a biomarker of lipid peroxidation) before LT. The study endpoint was 1-year LT mortality.ResultsThis study included 142 patients who underwent LT for HCC. Patients who survived the first year (n = 127) had significantly lower aged liver donors, significantly higher serum TAC levels, and significantly lower serum malondialdehyde levels compared with the non-survivors (n = 15). Logistic regression analysis found that serum TAC levels (odds ratio [OR] 0.275; 95% confidence interval [CI] 0.135, 0.562) and the age of the LT donor (OR 1.050; 95% CI 1.009, 1.094) were associated with 1-year LT mortality. There was an inverse association between serum levels of TAC and malondialdehyde levels (rho = –0.22).ConclusionsThere was an association between low serum TAC levels prior to LT for HCC and mortality during the first year after LT. There was an inverse association between serum TAC levels and lipid peroxidation as measured by malondialdehyde levels.

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“…Previously, we determined serum levels of malondialdehyde [ 24 ], caspase-cleaved cytokeratin-18 [ 25 ], and sCD40L [ 26 ] in some of those patients. In the current work, serum levels of substance P were analyzed to determine their association with LT mortality at one year.…”

Section: Methodsmentioning

confidence: 99%

Patients with high serum substance P levels previously to liver transplantation for hepatocellular carcinoma have higher risk of one-year liver transplantation mortality

et al. 2018

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PurposeSubstance P is a tachykinins family member with inflammatory effects. Higher circulating levels of substance P have been found in patients with liver diseases and in patients with higher severity of liver diseases. The objective of this study was to determine whether serum levels of substance P levels, prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) are associated with one-year LT mortality.Material and MethodsIn this observational retrospective unicenter study were included patients with LT for HCC. Serum levels of substance P were measured before LT. The end-point of the study was one-year mortality after LT.ResultsWe found that one-year survivor patients (n = 127) showed a lower age in liver donors (p = 0.03) and lower levels of serum substance P levels (p = 0.003) than non-survivor patients (n = 15). Logistic regression analysis showed that serum levels of substance P (levels) were associated with one-year mortality (Odds Ratio = 1.011; 95% CI = 1.004–1.018; p = 0.002) controlling for the age of the LT donor.ConclusionsWe believe that our study is the first study reporting data on circulating levels of substance P previously to LT for HCC, and an association between elevated levels of serum substance P before LT and mortality during the first year of LT.

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Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma

Cited by 24 publications

References 52 publications

Hyperoxia and oxidative stress in anesthesia and critical care medicine

Hyperoxia and oxidative stress in anesthesia and critical care medicine

Serum total antioxidant capacity prior to liver transplantation for hepatocellular carcinoma is associated with 1-year liver transplantation survival

Patients with high serum substance P levels previously to liver transplantation for hepatocellular carcinoma have higher risk of one-year liver transplantation mortality

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