Association Between Prediabetes and Osteoarthritis: A
                    Meta-Analysis

Xi, Li; Zhou, Yong; Liu, Jianxiu

doi:10.1055/a-1730-5251

Cited by 4 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, after further controlling for other factors such as BMI, the association became insignificant [ 46 ]. A potential reason for this insignificant association is that DM can be categorized as either prediabetes or DM since previous meta-analysis found no association between prediabetes and OA, indicating that mild hyperglycemia might not be associated with an increased risk of OA [ 40 ]. Another possible explanation is the mediation effect of obesity on DM and OA as a shared risk factor.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies included type 2 DM (T2DM) and specific joints such as knee and hand OA. Other narrative reviews have looked at the association between metabolic syndrome and OA [ 16 , 36 , 37 , 38 , 39 , 40 ]. Previous reviews were limited to specific joints for OA and specific forms of DM such as T2DM and did not investigate the impact of DM on symptoms and physical function among people with OA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Osteoarthritis and Diabetes: Where Are We and Where Should We Go?

et al. 2023

View full text Add to dashboard Cite

Diabetes mellitus (DM) and osteoarthritis (OA) are chronic noncommunicable diseases that affect millions of people worldwide. OA and DM are prevalent worldwide and associated with chronic pain and disability. Evidence suggests that DM and OA coexist within the same population. The coexistence of DM in patients with OA has been linked to the development and progression of the disease. Furthermore, DM is associated with a greater degree of osteoarthritic pain. Numerous risk factors are common to both DM and OA. Age, sex, race, and metabolic diseases (e.g., obesity, hypertension, and dyslipidemia) have been identified as risk factors. These risk factors (demographics and metabolic disorder) are associated with DM or OA. Other possible factors may include sleep disorders and depression. Medications for metabolic syndromes might be related to the incidence and progression of OA, with conflicting results. Given the growing body of evidence indicating a relationship between DM and OA, it is vital to analyze, interpret, and integrate these findings. Therefore, the purpose of this review was to evaluate the evidence on the prevalence, relationship, pain, and risk factors of both DM and OA. The research was limited to knee, hip, and hand OA.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteoarthritis and Diabetes: Where Are We and Where Should We Go?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…First, knee OA and cardiovascular diseases have common risk factors such as age and obesity. Moreover, knee OA can increase the risk of traditional risk factors for cardiovascular diseases, i.e., hypercholesterolemia [29], hypertension [30], aortic calcification [31], lumbar atherosclerotic calcification [32] or diabetes [33,34]. Of importance, a study with a 3 year follow-up reported a strong association between hypertension and impaired glucose tolerance with knee OA occurrence [35].…”

Section: Discussionmentioning

confidence: 99%

Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies

et al. 2022

View full text Add to dashboard Cite

Background Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes. Aims To map and grade all health outcomes associated with knee OA using an umbrella review approach. Methods The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance bias. The evidence was then graded from convincing (class I) to weak (class IV). Results Among 3,847 studies initially considered, five meta-analyses were included for a total of five different outcomes. Three adverse outcomes were significantly associated with knee OA (i.e., cardiovascular mortality, falls, and subclinical atherosclerosis). The presence of knee OA was associated with a significantly higher risk of cardiovascular mortality (odds ratio, OR = 1.17; 95%CI, confidence intervals: 1.02–1.34), falls (RR = 1.34; 95%CI: 1.10–1.64), and conditions associated with subclinical atherosclerosis (OR = 1.43; 95%CI: 1.003–2.05). The certainty of each of this evidence was weak. Conclusions Our umbrella review suggests that knee OA can be considered as putative risk factor for some medical conditions, including cardiovascular diseases and falls, however, it is important to note that the evidence is affected by potential biases.

show abstract

Is there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study

Wang,

Peng,

Yang

et al. 2024

Diabetol Metab Syndr

View full text Add to dashboard Cite

Objective The relationship between blood glucose levels and osteoarthritis (OA) is unclear. This study aimed to investigate the genetic causal relationship between blood glucose-related traits and OA. Methods We first performed univariate Mendelian randomization (UVMR) analyses using published genome-wide association study (GWAS) datasets with fasting glucose (FG), 2 h-glucose post-challenge glucose (2hGlu), and glycosylated hemoglobin (HbA1c) as exposures, and hip osteoarthritis (HOA) and knee osteoarthritis (KOA) as outcomes; then, we performed inverse analyses of them. We used Inverse-variance weighted (IVW) analysis as the primary analysis, and sensitivity analyses were performed. Moreover, we performed multivariate Mendelian randomization (MVMR) to estimate the independent effect of exposure on outcome after adjusting for body mass index (BMI). Summarized data for blood glucose-related traits were obtained from the MAGIC Consortium study of the glucose trait genome and for OA from the UK Biobank and arcOGEN. Summarized data for BMI were obtained from the GIANT Consortium meta-analysis of individuals of European ancestry. A two-sided p value < 0.05 in UVMR was considered suggestive of significance when p < 0.0167 (Bonferroni correction p = 0.05/3 exposures) was considered statistically significant. Results We found significant negative genetic causality of FG for HOA and KOA, and these associations remained significant after we adjusted for the effect of BMI [odds ratios (ORs) of 0.829 (0.687–0.999, p = 0.049) and 0.741 (0.570–0.964, p = 0.025)]. HbA1c also had an independent negative genetic causal effect on HOA after adjustment for BMI [0.665 (0.463–0.954, p = 0.027)]. At the same time, there was no evidence of reverse genetic causality of OA on blood glucose-related traits. Conclusion We further elucidated the relationship between blood glucose-related traits and OA by adjusting for the effect of BMI from a genetic causal perspective. This study provides new insights to further clarify the relationship between blood glucose levels and OA, as well as the pathogenesis, etiology and genetics of OA. Supplementary Information The online version contains supplementary material available at 10.1186/s13098-024-01517-3.

show abstract

Association Between Prediabetes and Osteoarthritis: A Meta-Analysis

Cited by 4 publications

References 36 publications

Osteoarthritis and Diabetes: Where Are We and Where Should We Go?

Osteoarthritis and Diabetes: Where Are We and Where Should We Go?

Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies

Is there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study

Contact Info

Product

Resources

About