Association Between Prematurity and Diagnosis of Neurodevelopment Disorder: A Case–Control Study

Soncini, Thaise Cristina Brancher; Belotto, Gabriella Antunes; Diaz, Alexandre Paim

doi:10.1007/s10803-019-04235-2

Cited by 3 publications

(6 citation statements)

References 40 publications

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“…A recent study reported that prematurity is independently associated with the diagnosis of neurological development disorders. Also, it showed that 19.5% of premature infants have ADHD, with a prevalence inversely proportional to gestational age (33). No studies were found showing an association between prematurity and LUTS.…”

Section: Discussionmentioning

confidence: 99%

Association between Attention Deficit Hyperactivity Disorder and lower urinary tract symptoms in children and adolescents in a community setting

et al. 2021

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Introduction: The present study aims to investigate the prevalence of lower tract urinary symptoms (LUTS) and symptoms of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents and their association in a community setting using validated scoring instruments. Materials and Methods: A cross-sectional study was carried out from February 2015 to December 2019, during which the parents or guardians of 431 children and adolescents from 5 to 13 years of age, attending a general pediatric outpatient clinic were interviewed. Results: The prevalence of ADHD symptoms and LUTS were 19.9% and 17.9%, respectively. Of the 82 children and adolescents with ADHD, 28% (23) had LUTS (OR 2.31, 95% CI 1.28 to 3.75, p=0.008). Mean total DVSS score in children in the group of children presenting ADHD symptom was significantly higher than those without ADHD symptom (10.2±4.85 vs. 4.9±2.95, p=0.002). Urgency prevailed among LUTS as the most frequent symptom reported by patients with ADHD symptoms (p=0.004). Analyzing all subscales of the DVSS, the items "When your child wants to pee, can't he wait? "Your child holds the pee by crossing his legs, crouching or dancing?" were higher in those with ADHD symptoms (p=0.01 and 0.02, respectively). Functional constipation was present in 36.4% of children with LUTS and 20.7% without LUTS (OR 4.3 95% CI 1-5.3 p=0.001). Conclusion:Children and adolescents with ADHD symptoms are 2.3 times more likely to have LUTS. The combined type of ADHD was the most prevalent among them.

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Section: Discussionmentioning

confidence: 99%

Association between Attention Deficit Hyperactivity Disorder and lower urinary tract symptoms in children and adolescents in a community setting

et al. 2021

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“…Premature birth has been established as a risk factor for ASD, with each week of shorter gestation being associated with an increased risk 12–14. A diagnosis of ASD is approximately 3 times more likely in infants born less than 27 weeks of gestation or weighing less than 1500 g when compared with infants born full term 12,15.…”

Section: Introductionmentioning

confidence: 99%

“…A diagnosis of ASD is approximately 3 times more likely in infants born less than 27 weeks of gestation or weighing less than 1500 g when compared with infants born full term 12,15. Full-term infants with neonatal morbidity, such as severe respiratory distress, low birth weight, intraventricular hemorrhage, or brain anomalies, have also been found to be at risk for ASD 14. Collectively, such high-risk infants are a vulnerable population who would benefit from methods of early identification of ASD.…”

Section: Introductionmentioning

confidence: 99%

“…12,15 Full-term infants with neonatal morbidity, such as severe respiratory distress, low birth weight, intraventricular hemorrhage, or brain anomalies, have also been found to be at risk for ASD. 14 Collectively, such high-risk infants are a vulnerable population who would benefit from methods of early identification of ASD.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Premature birth has been established as a risk factor for ASD, with each week of shorter gestation being associated with an increased risk. [12][13][14] A diagnosis of ASD is approximately 3 times more likely in infants born less than 27 weeks of gestation or weighing less than 1500 g when compared with infants born full term. 12,15 Full-term infants with neonatal morbidity, such as severe respiratory distress, low birth weight, intraventricular hemorrhage, or brain anomalies, have also been found to be at risk for ASD.…”

Section: Introductionmentioning

confidence: 99%

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Early Developmental Trends in High-Risk Neonates Later Diagnosed With Autism Spectrum Disorder

Carey

Tanner²,

Ratliff-Schaub³

et al. 2022

Pediatric Physical Therapy

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Purpose: We hypothesized that clinical data from a neonatal intensive care unit (NICU) infant developmental follow-up clinic would identify early manifestations of autism spectrum disorder (ASD). Methods: One hundred forty-four infants were identified; 72 later diagnosed with ASD and 72 controls. Retrospective chart review provided data from the Test of Infant Motor Performance (TIMP) and the Bayley Scales of Infant and Toddler Development, third edition (Bayley-III), between 8 and 26 months of age. Results: Between-group comparisons indicated no significant group difference in TIMP scores; however, Bayley-III scaled scores differed between the groups at 2 administration times. The within-group Bayley-III change scores declined significantly more for the ASD group in cognitive and communication subtests. Conclusion: High-risk neonates, due to prematurity or morbidity, later diagnosed with ASD demonstrated statistically significant differences, including a more precipitous drop in Bayley-III scores over time. Early, longitudinal developmental surveillance for neonates at risk of ASD is critical. What this adds to the evidence: Early identification of ASD is critical to optimize developmental outcomes in young children, including infants born prematurely or with neonatal morbidity, who are perceived to have an increased risk for ASD. Despite these findings, minimal research has been conducted to evaluate the utility of commonly administered norm-referenced developmental surveillance instruments to identify possible early signs of ASD in this high-risk population due to prematurity or neonatal morbidity and not familial association. The present study analyzed retrospectively collected clinical data from a NICU developmental follow-up clinic for 144 infants, 72 of which were later diagnosed with ASD and 72 sex- and gestational age-matched controls. Results demonstrated statistically significant poorer Bayley-III outcomes for the ASD group compared with controls at 2 different study time points, including a more precipitous drop in Bayley-III scaled scores over time. This study highlights the importance of early and longitudinal developmental surveillance for high-risk neonates at risk of ASD.

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The risk of autism spectrum disorder and intellectual disability but not attention deficit/hyperactivity disorder is increased in individuals with esophageal atresia

Kassa

Håkanson

Lilja

2022

Diseases of the Esophagus

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Knowledge of neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and intellectual disability (ID) in patients with esophageal atresia (EA) is scarce. The aims of this study were to investigate the prevalence and risk of ADHD, ASD and ID in individuals with EA. Data were obtained from four longitudinal population-based registries in Sweden and analyzed using Cox proportional hazards regression. Patients with EA born in Sweden in 1973–2018 were included together with five controls for each individual with the exposure matched on sex, gestational age at birth, birth year and birth county. Individuals with chromosomal aberrations and syndromes were excluded. In total, 735 individuals with EA and 3675 controls were included. Median age at time of the study was 20 years (3–48). ASD was found in 24 (3.9%), ADHD in 34 (5.5%) and ID in 28 (4.6%) individuals with EA. Patients with EA had a 1.66 times higher risk of ASD (95% confidence interval [CI], 1.05–2.64) and a 3.62 times higher risk of ID (95% CI, 2.23–5.89) compared with controls. The risk of ADHD was not significantly increased. ADHD medication had been prescribed to 88.2% of patients with EA and ADHD and to 84.5% of controls with ADHD. Individuals with EA have a higher risk of ASD and ID than individuals without the exposure. These results are important when establishing follow-up programs for children with EA to allow timely detection and consequentially an earlier treatment and support especially before school start.

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Association Between Prematurity and Diagnosis of Neurodevelopment Disorder: A Case–Control Study

Cited by 3 publications

References 40 publications

Association between Attention Deficit Hyperactivity Disorder and lower urinary tract symptoms in children and adolescents in a community setting

Association between Attention Deficit Hyperactivity Disorder and lower urinary tract symptoms in children and adolescents in a community setting

Early Developmental Trends in High-Risk Neonates Later Diagnosed With Autism Spectrum Disorder

The risk of autism spectrum disorder and intellectual disability but not attention deficit/hyperactivity disorder is increased in individuals with esophageal atresia

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