Association between prenatal cadmium exposure and cord blood DNA methylation

Park, Jaehyun; Kim, Jee Young; Kim, Esther; Won, Sungho; Kim, Woo Jin

doi:10.1016/j.envres.2022.113268

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…As previously mentioned, cadmium exposure has been shown to induce many epigenetic modifications during prenatal development. Maternal blood cadmium concentrations were found to be associated with genomic DNA hypomethylation of the gene, ATP9A, and variable methylations of the gene cg24904393, within the umbilical cord blood of human infants ( Park et al, 2022 ). ATP9A is important for phospholipid transporting ATPase activity.…”

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

“…ATP9A is important for phospholipid transporting ATPase activity. Decreased expression of this gene has been shown to increase extracellular vesicle release and apoptosis, as well as interrupt the recycling process of critical transport proteins, such as GLUT-1 ( Park et al, 2022 ). Additionally, the gene, cg24904393, encodes the plasminogen protein, which is vital in blood coagulation and fibrinolysis ( Park et al, 2022 ).…”

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

“…Decreased expression of this gene has been shown to increase extracellular vesicle release and apoptosis, as well as interrupt the recycling process of critical transport proteins, such as GLUT-1 ( Park et al, 2022 ). Additionally, the gene, cg24904393, encodes the plasminogen protein, which is vital in blood coagulation and fibrinolysis ( Park et al, 2022 ). Dysregulation of this gene can increase the risk of thrombosis, which proves to be detrimental to the developing offspring ( Park et al, 2022 ).…”

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

“…Additionally, the gene, cg24904393, encodes the plasminogen protein, which is vital in blood coagulation and fibrinolysis ( Park et al, 2022 ). Dysregulation of this gene can increase the risk of thrombosis, which proves to be detrimental to the developing offspring ( Park et al, 2022 ). Moreover, within the cord blood of cadmium-exposed infants, hundreds of cadmium-associated differentially methylated regions (DMRs) were identified.…”

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

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The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

Lawless

Xie

Zhang

2023

Front. Cell Dev. Biol.

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Exposure to cadmium during pregnancy, from environmental or lifestyle factors, has been shown to have detrimental fetal and placental developmental effects, along with negatively impacting maternal health during gestation. Additionally, prenatal cadmium exposure places the offspring at risk for developing diseases in infancy, adolescence, and adulthood. Although given much attention, the underlying mechanisms of cadmium-induced teratogenicity and disease development remain largely unknown. Epigenetic changes in DNA, RNA and protein modifications have been observed during cadmium exposure, which implies a scientific premise as a conceivable mode of cadmium toxicity for developmental origins of health and disease (DOHaD). This review aims to examine the literature and provide a comprehensive overview of epigenetic alterations induced by prenatal cadmium exposure, within the developing fetus and placenta, and the continued effects observed in childhood and across generations.

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Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

Section: Cadmium-associated Epigenetics Alterations During Pregnancymentioning

confidence: 99%

See 2 more Smart Citations

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

Lawless

Xie

Zhang

2023

Front. Cell Dev. Biol.

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“…10,11 DNA methylation also acts as an epigenetic marker sensitive to environmental factors, thus making it an ideal candidate mechanism for revealing how exposure to the environment shapes gene expression and contributes to diseases. 12 Previous epigenome-wide association studies (EWAS) have shown that heavy metals including arsenic, 13 cadmium, 14,15 lead, 16,17 copper, 18,19 manganese, 17 and zinc 20 were associated with changes in DNA methylation. However, most investigations analyzed the DNA methylation signatures with prenatal metals exposures, [13][14][15]17,18,21 with less attention given to adults, particularly older adults who are environmentally susceptible.…”

Section: Introductionmentioning

confidence: 99%

Associations of Heavy Metals with Cognitive Function: An Epigenome‐Wide View of DNA Methylation and Mediation Analysis

Wei,

Zhou,

Xiao

et al. 2024

Annals of Neurology

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ObjectiveExposure to heavy metals has been reported to be associated with impaired cognitive function, but the underlying mechanisms remain unclear. This pilot study aimed to identify key heavy metal elements associated with cognitive function and further explore the potential mediating role of metal‐related DNA methylation.MethodsBlood levels of arsenic, cadmium, lead, copper, manganese, and zinc and genome‐wide DNA methylations were separately detected in peripheral blood in 155 older adults. Cognitive function was evaluated using the Mini‐Mental State Examination (MMSE). Least absolute shrinkage and selection operator penalized regression and Bayesian kernel machine regression were used to identify metals associated with cognitive function. An epigenome‐wide association study examined the DNA methylation profile of the identified metal, and mediation analysis investigated its mediating role.ResultsThe MMSE scores showed a significant decrease of 1.61 (95% confidence interval [CI]: −2.64, −0.59) with each 1 standard deviation increase in ln‐transformed arsenic level; this association was significant in multiple‐metal models and dominated the overall negative effect of 6 heavy metal mixture on cognitive function. Seventy‐three differentially methylated positions were associated with blood arsenic (p < 1.0 × 10−5). The methylation levels at cg05226051 (annotated to TDRD3) and cg18886932 (annotated to GAL3ST3) mediated 24.8% and 25.5% of the association between blood arsenic and cognitive function, respectively (all p < 0.05).InterpretationBlood arsenic levels displayed a negative association with the cognitive function of older adults. This finding shows that arsenic‐related DNA methylation alterations are critical partial mediators that may serve as potential biomarkers for further mechanism‐related studies. ANN NEUROL 2024

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Epigenetics and environmental health

Zhang,

Hu,

et al. 2024

Front. Med.

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Association between prenatal cadmium exposure and cord blood DNA methylation

Cited by 8 publications

References 41 publications

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

Associations of Heavy Metals with Cognitive Function: An Epigenome‐Wide View of DNA Methylation and Mediation Analysis

Epigenetics and environmental health

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