Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates

Li, Jincan; Yang, Limei; He, Gengsheng; Wang, Binbin; Miao, Maohua; Ji, Honglei; Wen, Shi Wu; Cao, Wencheng; Wei, Yuan; Liang, Hong

doi:10.1016/j.ecoenv.2022.114130

Cited by 5 publications

(3 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Perfluoroalkyl substances (PFAS) are the second most investigated EDAs in our review corpus (four studies), and these studies also reveal quite divergent results. While PFAS exposure was associated with increased AGD in one study 24 , another study reported that it decreased AGD length in female infants. 25 No relationship was found in two other studies.…”

Section: Endocrine Disrupting Agents and Anogenital Distancementioning

confidence: 85%

Anogenital Distance and Prenatal Androgen Exposure in Female Fetus and Newborns: A Systematic Review

Halıcı Öztürk,

Atalay

2023

Adv Res Obstet Gynaecol

View full text Add to dashboard Cite

The aim of this systematic review is to examine the relationship between anogenital distance (AGD) and prenatal androgen exposure in female offspring, and to assess whether there is sufficient scientific evidence that AGD could be a biomarker of in utero exposure in girls. A systematic approach was adopted to the screening and selection of the studies through Pub Med database. 959 documents were found in Pub Med search, 919 of them were excluded for lack of relevance, and 40 studies were included in the review. A significant portion of the selected studies (25 papers) focuses on the effect of exposure to endocrine disrupting agents (EDAs) such as phthalates, bisphenol A, and perfluoroalkyl substances. The other exposure factors examined in the studies are polycystic ovary syndrome, smoking and alcohol use, and maternal stressful life events. In 19 studies, a significant association has been reported between prenatal exposure factors and AGD length in female fetus and newborns. In the remaining 21 studies, no significant association was found. In conclusion, although there is still no a clear and conclusive evidence, a growing body of research provides data supporting that AGD may be considered a reliable marker of in utero androgen exposure in female infants. Our review highlights significant knowledge gaps with regard to some androgen or anti-androgen exposure factors. Much more research needed to understand the relationship of anogenital distance with in utero hormonal milieu and offspring’s reproductive system development.

show abstract

Section: Endocrine Disrupting Agents and Anogenital Distancementioning

confidence: 85%

Anogenital Distance and Prenatal Androgen Exposure in Female Fetus and Newborns: A Systematic Review

Halıcı Öztürk,

Atalay

2023

Adv Res Obstet Gynaecol

View full text Add to dashboard Cite

show abstract

“…One recent Spanish study assessed the joint effects of 18 persistent organic pollutants on AGD in 129 children and found that co-exposure to persistent organic pollutants during pregnancy was associated with a reduced AGD in males but not in females [ 51 ]. Interestingly, another study from Shanghai, China, demonstrated that exposure to perfluoroalkyl substances mixture during pregnancy was associated with increased AGD in female neonates [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study

et al. 2023

View full text Add to dashboard Cite

Background Considerable attention has been paid to reproductive toxicity of fine particulate matter (PM2.5). However, the relationship between prenatal PM2.5 exposure and anogenital distance (AGD) has not been well studied. We aim to investigate the potential effects of prenatal exposure to PM2.5 on newborn AGD. Methods Prenatal PM2.5 exposure of 2332 participates in Shanghai (2013–2016) was estimated using high-performance machine learning models. Anoscrotal distance (AGDas) in male infants and anofourchette distance (AGDaf) in female infants were measured by well-trained examiners within 3 days after birth. We applied multiple linear regression models and multiple informant models to estimate the association between prenatal PM2.5 exposure and AGD. Results Multiple linear regression models showed that a 10 μg/m3 increase in PM2.5 exposure during full pregnancy, the second and third trimesters was inversely associated with AGDas (adjusted beta = − 1.76, 95% CI: − 2.21, − 1.31; − 0.73, 95% CI: − 1.06, − 0.40; and − 0.52; 95% CI: − 0.87, − 0.18, respectively) in males. A 10 μg/m3 increase in PM2.5 exposure during the full pregnancy, the first, second, and third trimesters was inversely associated with AGDaf (adjusted beta = − 4.55; 95% CI: − 5.18, − 3.92; − 0.78; 95% CI: − 1.10, − 0.46; − 1.11; 95% CI: − 1.46, − 0.77; − 1.45; 95% CI: − 1.78, − 1.12, respectively) in females after adjusting for potential confounders. Multiple informant models showed consistent but slightly attenuated associations. Conclusion Our study observed a significant association between gestational PM2.5 exposure during pregnancy and shortened AGD in newborns, and provided new evidence on potential reproductive toxicity of prenatal PM2.5 exposure.

show abstract

“…Reduced birth weight was also reported as a consequence of maternal PFNA, PFDA, PFUnA, PFDeA, and PFDoA exposure [187,188]. Anogenital distance (AGD) is a measure of endocrine disruption during in utero development, and a link between increased female neonatal AGD and maternal PFAS concentrations has been reported [189]. However, similar to other reproductive endpoints, shortened AGD in female infants at three months of age is associated with maternal serum concentrations of PFOS, PFHxS, and PFNA [190], while two more studies did detect a correlation between maternal serum PFAS and AGD in females [191,192].…”

Section: Developmental Effectsmentioning

confidence: 99%

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction

González-Alvarez,

Antwi-Boasiako,

Keating

2024

Toxics

View full text Add to dashboard Cite

Per- and poly-fluoroalkylated substances (PFAS) are a large group of chemicals that persist both in the environment and in the body. Legacy PFAS, e.g., perfluorooctanoic acid and perfluorooctane sulfonic acid, are implicated as endocrine disruptors and reproductive and developmental toxicants in epidemiological and animal model studies. This review describes female reproductive outcomes of reported studies and includes where associative relationships between PFAS exposures and female reproductive outcomes have been observed as well as where those are absent. In animal models, studies in which PFAS are documented to cause toxicity and where effects are lacking are described. Discrepancies exist in both human and animal studies and are likely attributable to human geographical contamination, developmental status, duration of exposure, and PFAS chemical identity. Similarly, in animal investigations, the model used, exposure paradigm, and developmental status of the female are important and vary widely in documented studies. Taken together, support for PFAS as reproductive and developmental toxicants exists, although the disparity in study conditions and human exposures contribute to the variation in effects noted.

show abstract

Association between prenatal exposure to perfluoroalkyl substances and anogenital distance in female neonates

Cited by 5 publications

References 77 publications

Anogenital Distance and Prenatal Androgen Exposure in Female Fetus and Newborns: A Systematic Review

Anogenital Distance and Prenatal Androgen Exposure in Female Fetus and Newborns: A Systematic Review

Prenatal exposure to fine particulate matter and newborn anogenital distance: a prospective cohort study

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction

Contact Info

Product

Resources

About