Association between prenatal nickel exposure and preterm low birth weight: possible effect of selenium

Sun, Xiaojie; Jiang, Yangqian; Xia, Wei; Jin, Shuna; Liu, Wenyu; Lin, Xin; Liu, Hongxiu; Chen, Xiaomei; Yang, Peng; Han, Li; Lü, Bin; Xu, Shunqing; Li, Yuanyuan; Shen, Xiantao

doi:10.1007/s11356-018-2622-x

Cited by 28 publications

(16 citation statements)

References 38 publications

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“…However, Se is involved in numerous biochemical/biological processes (inter alia, the oxidative balance, inflammatory and immune processes and apoptosis) that are part of the complex processes of early placental development [13]. Selenium’s role in heavy metal detoxification has also been taken into consideration [26,27].…”

Section: Discussionmentioning

confidence: 99%

The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

2019

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It has not yet been established, whether or not the maternal serum selenium (Se) in early pregnancy may be a risk marker of small-for-gestational age (SGA) birth weight. Selenium is important for human health and is involved in oxidative balance, a key element in the development of the placenta and fetus. This innovative study was nested in a prospective cohort of 750 women recruited in the 10–14th week of a single pregnancy, all of whom were healthy during recruitment. We examined mothers delivering SGA infants (with birth weight <10th percentile) (n = 48) and matched mothers delivering appropriate-for-gestational age (AGA) infants (between 10–90th percentile) (n = 192). We measured the maternal microelement concentrations in the serum from the 10–14th gestational week, using the inductively coupled plasma mass spectrometry (ICP-MS). The odds ratios of SGA (and 95% confidence intervals) were assessed in logistic regression. The mean maternal Se concentrations were lower in mothers in the SGA group compared to the AGA group (59.60 vs. 62.54 µg/L; p = 0.020). Women in the lowest Q1 quartile of Se (≤56.60 µg/L) have about three times higher risk of SGA compared to women in the higher quartiles (Q2 or Q4); the odds ratio of SGA was OR = 3.02 (p = 0.019) for Q1 vs. Q2 quartile. The risk profile graph confirms the results. We found that excessive pre-pregnancy BMI (body mass index) affected the estimated SGA odds ratios. Early pregnancy maternal serum selenium status can be a risk marker of SGA newborns and more research is needed in larger groups.

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Section: Discussionmentioning

confidence: 99%

The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

2019

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“…Sun et al. (2018) described the possible link between prenatal nickel exposure and pre‐term low birth weight (PLBW). Nickel was analysed in urine samples from 408 pregnant women (102 PLBW; 306 controls) in China.…”

Section: Assessmentmentioning

confidence: 99%

“…The authors also reported that high blood pressure in mothers correlated with higher concentrations of nickel in amniotic fluid. Sun et al (2018) described the possible link between prenatal nickel exposure and pre-term low birth weight (PLBW). Nickel was analysed in urine samples from 408 pregnant women (102 PLBW; 306 controls) in China.…”

Section: Developmental Toxicitymentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

101

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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“…Nickel is considered a low toxicity metal and is not nutritionally required. However, higher Ni exposure among pregnant women is associated with increased risk of preterm birth and low birth weight [ 81 ] and with congenital heart disease [ 37 , 82 ] reported no statistical difference between Ni exposure and markers of gestational diabetes. [ 15 ] reported lower levels (0.107 ± 0.081 with an interquartile range of below the LOQ to 1.7.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

Michelsen-Correa¹,

Martin

Kirk

2021

IJERPH

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This paper surveys the existing scientific literature on metals concentrations in meconium. We examine some 32 papers that analyzed meconium for aluminum, arsenic, barium, calcium, chromium, copper, iron, lithium, magnesium, manganese, zinc, lead, mercury, manganese, molybdenum, nickel, phosphorus, lead, antimony, selenium, tin, vanadium, and zinc. Because of the lack of detail in the statistics it is not possible to do a rigorous meta-analysis. What stands out is that almost every study had subjects with seemingly large amounts of at least one of the metals. The significance of metals in meconium is not clear beyond an indication of exposure although some studies have correlated metals in meconium to a number of adverse outcomes. A number of outstanding questions have been identified that, if resolved, would greatly increase the utility of meconium analysis for assessment of long-term gestational metals exposures. Among these are questions of the developmental and long-term significance of metals detected in meconium, the kinetics and interactions among metals in maternal and fetal compartments and questions on best methods for meconium analyses.

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Association between prenatal nickel exposure and preterm low birth weight: possible effect of selenium

Cited by 28 publications

References 38 publications

The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns

Update of the risk assessment of nickel in food and drinking water

Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review

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