Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital

Laviano, E.; Rubio, Maria Sanchez; González-Nicolás, María Teresa Cuevas; Palacian, M.P.; López, Javier; Gilaberte, Yolanda; Calmarza, Pilar; Rezusta, Antonio; Serrablo, Alejandro

doi:10.1371/journal.pone.0230336

Cited by 26 publications

(20 citation statements)

References 29 publications

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“…Laviano et. al revealed that preoperative 25-OH vitamin D levels were not only related with development of hospital acquired infections but also with Clavien-Dindo scale of postoperative complications(32). In contrast to their results, we observed no association between Clavien-Dindo scale and 25-OH vitamin D levels in our study.…”

contrasting

confidence: 99%

The relation of preoperative 25-OH Vitamin D Levels with Postoperative Complications in Patients undergoing Colorectal Cancer Surgery

Balci

Çetindağ

Kılınç

et al. 2020

Preprint

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Background: To investigate the effect of preoperative 25-OH vitamin D levels on postoperative complications in patients undergoing colorectal cancer surgery.Methods: Consecutive newly diagnosed colorectal cancer patients who met the inclusion criteria were prospectively included in this single-center observational study. Preoperative 25-OH vitamin D levels were measured and analyzed for association with postoperative complications using univariable and multivariable logistic regression analyses.Results: A total of 104 colorectal cancer patients were included in this study. Preoperative 25-OH vitamin D levels were found to be <10 ng/ml in 31 (29.8%) patients, 10-20 ng/ml in 42 (40.4%) patients, between 20-30 ng/ml in 25 (24%) patients and >30 ng/ml in 6 (5.8%) patients. In patients with infective complications, the mean value of 25-OH vitamin D levels were 12.33 (±6.306) ng/ml which was found to be statistically significant (p:0.026). In univariable logistic regression analyses, variables found to be associated with postoperative complications were age ≥ 65, male gender and preoperative 25-OH vitamin D levels, whereas in multivariable analyses, preoperative levels of 25-OH vitamin D were not found to be related with postoperative complications.Conclusions: We demonstrated that vitamin D deficiency is a significant risk factor for development of infective complications and seems to be independently associated with postoperative complications in patients undergoing colorectal cancer surgery.

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confidence: 99%

The relation of preoperative 25-OH Vitamin D Levels with Postoperative Complications in Patients undergoing Colorectal Cancer Surgery

Balci

Çetindağ

Kılınç

et al. 2020

Preprint

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“…Vitamin D supplementation to raise serum 25(OH)D concentrations can help reduce hospitalassociated infections [131]. Concentrations of at least 40-50 ng/mL (100-125 nmol/L) are indicated on the basis of observational studies [132,133]. During the COVID-19 epidemic, all people in the hospital, including patients and staff, should take vitamin D supplements to raise 25(OH)D concentrations as an important step in preventing infection and spread.…”

Section: Hospital-acquired Infectionsmentioning

confidence: 99%

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

et al. 2020

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The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing the risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D supplementation might be a useful measure to reduce risk. Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lungs, leading to pneumonia, as well as increasing concentrations of anti-inflammatory cytokines. Several observational studies and clinical trials reported that vitamin D supplementation reduced the risk of influenza, whereas others did not. Evidence supporting the role of vitamin D in reducing risk of COVID-19 includes that the outbreak occurred in winter, a time when 25-hydroxyvitamin D (25(OH)D) concentrations are lowest; that the number of cases in the Southern Hemisphere near the end of summer are low; that vitamin D deficiency has been found to contribute to acute respiratory distress syndrome; and that case-fatality rates increase with age and with chronic disease comorbidity, both of which are associated with lower 25(OH)D concentration. To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D 3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L). For treatment of people who become infected with COVID-19, higher vitamin D 3 doses might be useful. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations.

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“…Vitamin D supplementation to raise serum 25(OH)D concentrations can help reduce hospitalassociated infections [131]. Concentrations at least 40-50 ng/ml (100-125 nmol/l) are indicated on the basis of observational studies [132], [133]. During the COVID-19 epidemic, all people in the hospital, including patients and staff, should take vitamin D supplements to raise 25(OH)D concentrations as an important step in preventing infection and spread.…”

Section: Recommendations 41 Hospital-acquired Infectionsmentioning

confidence: 99%

Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

Grant

Lahore

McDonnell

et al. 2020

Preprint

581

595

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The world is in the grips of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D supplementation might be a useful measure to reduce risk. Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lungs, leading to pneumonia, as well as increase concentrations of anti-inflammatory cytokines. Several observational studies and clinical trials reported that vitamin D supplementation reduced risk of influenza, whereas others did not. Evidence supporting the role of vitamin D in reducing risk of COVID-19 includes that the outbreak occurred in winter, a time when 25-hydroxyvitamin D [25(OH)D] concentrations are lowest; that the number of cases in the Southern Hemisphere near the end of summer are low; that vitamin D deficiency has been found to contribute to acute respiratory distress syndrome, and that case-fatality rates increase with age and with chronic disease comorbidity, both of which are associated with lower 25(OH)D concentration. To reduce risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40–60 ng/ml (100–150 nmol/l). For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations.

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Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital

Cited by 26 publications

References 29 publications

The relation of preoperative 25-OH Vitamin D Levels with Postoperative Complications in Patients undergoing Colorectal Cancer Surgery

The relation of preoperative 25-OH Vitamin D Levels with Postoperative Complications in Patients undergoing Colorectal Cancer Surgery

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

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