Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India

Shantha, Ghanshyam Palamaner Subash; Kumar, Anita; Jeyachandran, Vijay; Rajamanickam, Deepan; Rajkumar, K.; Salim, Shihas; Subramanian, Kuyilan Karai; Natesan, Senthilkumar

doi:10.1186/1756-6614-2-2

Cited by 80 publications

(69 citation statements)

References 31 publications

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“…Moreover, SCH was found to be commoner than OH. Our findings with regard to incidence of SCH and OH are similar with other authors like Rezos et al, 17 Das et al, 18 and Shantha et al 19 Our study revealed that greater number of patients belonged to the urban population as compared with the rural population. Similar trend has been reported by Saxena et al 6 In the present study, a predominance of females was noted in cases of hypothyroidism.…”

Section: Discussionsupporting

confidence: 82%

Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia

Chandra¹,

Shekhar²,

Singh³

et al. 2017

International Journal of Advanced and Integrated Medical Sciences

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Objective: The aims of the present study were to determine the prevalence of hypothyroidism, both subclinical hypothyroidism (SH) and overt hypothyroidism (OH), its correlation with dyslipidemia, and whether replacement therapy with levothyroxine has an effect on plasma lipid profile, i.e., total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) of hypothyroid patients. Materials and methods:A prospective, open-label, observational, clinical study was conducted by the Department of Pharmacology in collaboration with the Department of Medicine, Rohilkhand Medical College & Hospital, for a period of 10 months. A total of 50 patients, age 18 to 65 years, of both genders, who were newly diagnosed cases of hypothyroidism with dyslipidemia (Adult Treatment Panel III National Cholesterol Education Program guidelines) were recruited for the study. Levothyroxine replacement therapy was administered and the patients were reassessed at 6 and 36 weeks for an effect on lipid profile and body mass index. Results:In cases of OH, baseline TC, TG, LDL, and HDL were 231. 01 ± 27.84, 148.18 ± 10.72, 149.07 ± 12.38, and 35.42 ± 6.73 mg/dL, which was reduced to 177. 33 ± 23.17, 123.15 ± 29.50, 118.44 ± 29.85, and 47.86 ± 8.53 mg/dL after 36 weeks of levothyroxine therapy (p < 0.05). Conclusion:In cases of OH associated with dyslipidemia, levothyroxine therapy achieved a favorable lipid profile in significant number of cases.

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Section: Discussionsupporting

confidence: 82%

Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia

Chandra¹,

Shekhar²,

Singh³

et al. 2017

International Journal of Advanced and Integrated Medical Sciences

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“…In terms of inflammation and thyroid, metabolic syndrome is clearly associated, for instance see Shantha et al (2009) and Ruhla et al (2010). The transition from metabolic syndrome to type 2 diabetes is a well-known risk.…”

mentioning

confidence: 99%

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Merrill

2015

Journal of Theoretical Biology

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“…This may be important because small-for-dates (included in low-birthweight) babies are more likely to develop hypertension, diabetes and related 'metabolic syndrome' disorders in adult life (35) . Indian women tend to have small babies (36,37) and Indians are particularly prone to metabolic syndrome (36,38) , which has an association with subclinical hypothyroidism (39) and multinodular goitre in regions with iodine deficiency (20,21) .…”

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confidence: 99%

Iodine status during pregnancy in India and related neonatal and infant outcomes

Lean

Yajnik

et al. 2013

Public Health Nutr.

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Objective: To document iodine status in Indian pregnancies, associations with maternal diet and demographics, and offspring developmental measures. Design: Longitudinal study following mothers through pregnancy and offspring up to 24 months. Setting: Rural health-care centre (Vadu) and urban antenatal clinic (Pune) in the Maharashtra region of India. Subjects: Pregnant mothers at 17 (n 132) and 34 weeks' (n 151) gestation and their infants from birth to the age of 24 months. Results: Median urinary iodine concentration (UIC) was 203 and 211 mg/l at 17 and 34 weeks of pregnancy, respectively (range 26-800 mg/l). Using the UIC distribution adjusted for within-person variation, extreme UIC quartiles were compared for predictors and outcomes. There was no correlation between UIC at 17 and 34 weeks, but 24 % of those with UIC in the lowest quartile at 17 weeks had UIC in the same lowest quartile at 34 weeks. Maternal educational, socioeconomic status and milk products consumption (frequency) were different between the lowest and highest quartile of UIC at 34 weeks. Selected offspring developmental outcomes differed between the lowest and highest UIC quartiles (abdominal circumference at 24 months, subscapular and triceps skinfolds at 12 and 24 months). However, UIC was only a weak predictor of subscapular skinfold at 12 months and of triceps skinfold at 24 months. Conclusions: Median UIC in this pregnant population suggested adequate dietary provision at both gestational stages studied. Occasional high results found in spot samples may indicate intermittent consumption of iodine-rich foods. Maternal UIC had limited influence on offspring developmental outcomes.

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Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India

Abstract: Hypothyroidism is associated with metabolic syndrome and females are more at risk. Metabolic syndrome patients with a raised HsCRP are at significant risk of having sub-clinical hypothyroidism.

Cited by 80 publications

References 31 publications

Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia

Effect of Levothyroxine Therapy on Hypothyroidism-induced Dyslipidemia

Thyroid autoimmunity as a window to autoimmunity: An explanation for sex differences in the prevalence of thyroid autoimmunity

Iodine status during pregnancy in India and related neonatal and infant outcomes

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