Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis

Li, Xiaoying; Liu, Qu; Zhong, Yixi; Zhao, Yingjie; Chen, Hongyan; Lu, Daru

doi:10.1007/s00432-013-1446-9

Cited by 23 publications

(19 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…41 In a large meta-analysis, Peng et al found that MMP2 (-1306C>T and -735C>T) and MMP7 -181A>G polymorphisms play allele-specific roles in cancer development, while the MMP9 -1562C>T polymorphism did not appear to be a major risk factor for cancer. 42 Another meta-analysis by Li et al, 43 focusing on digestive tract cancers, demonstrated an association of polymorphisms in the promoter regions of specific MMPs with increased (MMP1 and -7) or decreased (MMP2 and -9) susceptibility, while Yang et al 44 further suggested that the MMP7 -181A>G polymorphism may contribute to susceptibility to gastric cancer. In their meta-analysis of studies investigating the role of the -1171(5A>6A) polymorphism in the promoter region of MMP3, Yang et al 45 did not find an association with overall cancer risk, suggesting that this polymorphism may be related to a decreased cancer risk in general in Asian populations when specifically compared with gastrointestinal cancers.…”

mentioning

confidence: 99%

Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

View full text Add to dashboard Cite

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine involution and organogenesis, inflammation and wound healing, vascular and autoimmune disease progression. Pertinent to this review, the role of MMPs in cancer biology is fairly well researched and documented, and remains a subject of continuing intense investigation. Not only are several MMPs overexpressed in head and neck squamous cell carcinomas (HNSCCs), expression has been correlated with salient tumorigenic hallmarks, such as cell proliferation, angiogenesis, invasion, and metastasis. The utility of changes in the expression profile, as well as various MMP polymorphisms as potential prognostic markers in oral cancers and oral premalignant lesions, have been investigated. Furthermore, the potential therapeutic utility of targeting MMPs in cancer remains attractive, although outcomes in this respect appear so far to be less encouraging with respect to HNSCCs. Because of the disappointing results observed in clinical trials where MMP-targeting regimens for HNSCCs utilized broad-spectrum small MMP catalytic site inhibitors, investigators now envision new strategies for MMP-specific targeting based on the recognition of new noncatalytic MMP domains with distinct functions. This review provides an overview of MMP activities in general and in cancers, and an update of their activities in HNSCC. Specifically, their role in the development and progression of HNSCC and their function as signaling molecules is discussed. Finally, their role as potential prognostic biomarkers and therapeutic targets in HNSCC is revisited.

show abstract

mentioning

confidence: 99%

Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

View full text Add to dashboard Cite

show abstract

“…Association studies revealed that the various SNPs within MMP2 , MMP9 and TIMP2 pre‐disposed to different disease states, for example bladder cancer susceptibility (Yan et al., ), prostate cancer (dos Reis et al., ), breast cancer development and survival (Slattery et al., ), digestive cancers (Li et al., ; Park, Kim, Kim, & Kim, ), head and neck cancer (Zhang et al., ), lung cancer (Wang & Cai, ), gallbladder cancer (Sharma, Misra, Kumar, & Mittal, ), retinal vein occlusion (Ortak et al., ) or chronic obstructive pulmonary disease risk (Mocchegiani, Giacconi, & Costarelli, ; Tesfaigzi et al., ). However, there is no information available on the associations between MMP2 , MMP9 and TIMP2 and male infertility.…”

Section: Discussionmentioning

confidence: 99%

MMP2,MMP9andTIMP2polymorphisms affect sperm parameters but not fertility in Polish males

et al. 2016

View full text Add to dashboard Cite

Proper function of the blood-testis barrier is pivotal to spermatogenesis. Synchronised action of matrix metalloproteinases (MMP) and their inhibitors (TIMP) is mandatory to maintain dynamic balance of the barrier. Therefore, the association of functional genetic variants of MMP-2, MMP-9 and TIMP-2 and male infertility was studied. A total of 416 infertile males and 421 healthy subjects were genotyped for 7 SNPs within MMP2, MMP9 and TIMP2 genes, along with the assessment of semen parameters (concentration, motility and morphology of spermatozoa). No association was observed between the studied genotypes and male infertility. However, higher sperm concentration was associated with TIMP2 rs8080623 C and rs2277698 T variants among infertile men, and with MMP9 rs17576 A minor allele in controls (p < .05). TIMP2 rs9900972 T and rs2277698 T allele were associated with higher percentage of morphologically normal spermatozoa among controls. MMP2 rs2285053 TT homozygous infertile patients presented higher percentage of spermatozoa displaying nonprogressive motility. Haplotype analysis revealed strong linkage disequilibrium between the studied loci (5 of 8 possible TIMP2 haplotypes, and 3 of 4 possible MMP2 and MMP9 were found). None of the haplotypes showed association with infertility. This study results suggest an association between MMP9 and TIMP2 SNPs with sperm parameters, but not infertility.

show abstract

“…MMP2, MMP3, and MMP9 are three important members of the MMP family, and previous studies reported that polymorphisms of MMP2, MMP3, and MMP9 were associated with the risk and prognosis of several cancers such as bladder, gastric, breast, and oral cancer, as well as osteosarcoma (Pereira et al, 2012;Saeed et al, 2013;Yang et al, 2014;Wieczorek et al, 2014;Yan et al, 2014;Wen et al, 2014). Furthermore, there have been several reports on the association between MMP2, MMP3, and MMP9 polymorphisms, and the development and prognosis of ESCC, but the results are inconsistent (Zhang et al, 2005;Wu et al, 2008;Bradbury et al, 2009;Peng et al, 2010;Li et al, 2013). The discrepancy between these results may be caused by variable genetic distributions in different populations, or dissimilar study designs and sample sizes.…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer

Zhang

2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. We conducted a case-control study to investigate the role of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 single nucleotide polymorphisms on susceptibility to esophageal squamous cell carcinoma (ESCC) in a Chinese population, and their association with environmental factors. A total of 226 patients with ESCC, and 226 age-and gender-matched healthy controls were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was carried out on MMP2 -1306 C>T (rs243865), MMP3 -1171 5A>6A (rs3025058), and MMP9 -1562 C>T (rs3918242) genotypes. Unconditional regression analysis showed that individuals carrying the MMP2 -1306 TT genotype had a decreased incidence of ESCC compared to those with the CC genotype [odds ratio (OR) = 0.32; 95% confidence interval (CI), 0.10-0.89, P value = 0.02]. Moreover, MMP9 -1562 CC carriers were associated with an increased ESCC risk compared to those with the TT genotype (OR = 2.71; 95%CI, 1.04-7.87, P value = 0.02). In the Cox proportional hazards model, after adjusting for potential confounding factors, patients carrying the MMP9 -1562 CC genotype had a significantly increased risk of death from ESCC (hazard ratio = 2.97; 95%CI, 1.25-6.87, P value = 0.005). 4617Matrix metalloproteinases and esophageal cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4616-4624 (2015) In conclusion, this study showed that the MMP2 -1306 TT and MMP9 -1562 CC genotypes were associated with increased ESCC, and patients carrying the MMP9 -1562 CC genotype had a significantly increased risk of death from ESCC.

show abstract

Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis

Cited by 23 publications

References 72 publications

Matrix metalloproteinases in head and neck cancer: current perspectives

Matrix metalloproteinases in head and neck cancer: current perspectives

MMP2,MMP9andTIMP2polymorphisms affect sperm parameters but not fertility in Polish males

Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer

Contact Info

Product

Resources

About