Association between protein arginine N-methyltransferase 1 polymorphism and overt diabetic nephropathy: Role of asymmetric dimethylarginine in vascular tone

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

“…More recently, PRMT1 has been linked to cancer metabolism through promoting glycolysis in hepatocellular carcinoma and colorectal cancer (Li et al, 2023; Liu et al, 2024), as well as fatty acid metabolism in hepatocellular carcinoma and breast cancer (Yamamoto et al, 2024; Yan et al, 2024). PRMT1 has also been shown to play an important roles beyond oncology, including in cardiovascular disease (Couto e Silva et al, 2020), diabetes (Iwasaki, 2024) and neurodegenerative diseases (Angelopoulou et al, 2023) such as amyotrophic lateral sclerosis (Aikio et al, 2021). Many of the above studies have shown that knockdown or knockout of PRMT1 in vitro and in vivo has significant effect on disease phenotypes.…”