Association between protozoa in sputum and asthma: A case-control study

Woerden, H. van; Ratier-Cruz, Adriana; Aleshinloye, Olabode B.; Martínez‐Girón, Rafael; Gregory, Clive James; Matthews, Ian

doi:10.1016/j.rmed.2010.11.016

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…In a study in which the relationship between protozoa and asthma was evaluated [6], data supported the hypothesis that protozoa were more prevalent in patients diagnosed with asthma than in comparable controls. That study also investigated the relationship between presence of protozoa in sputum and dampness in the house and the data did not support the hypothesis that an increased prevalence of protozoa in sputum was associated with living in damp houses.…”

Section: Discussionmentioning

confidence: 81%

“…Lophomonas blattarum is another example of a single-cell eukaryote that occasionally appears to infect humans. Only a few articles reported that Lophomonas blattarum and other flagellated protozoa caused bronchopulmonary infections in humans [2–6]. No human cases of bronchopulmonary flagellated protozoa were reported from Turkey, but only a few cases were diagnosed as L. blattarum by Levent Doğancı (Bayındır Hospital, Turkey, personal communication).…”

Section: Introductionmentioning

confidence: 99%

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Putative Bronchopulmonary Flagellated Protozoa in Immunosuppressed Patients

Kilimcioğlu

Havlucu

Girginkardeşler

et al. 2014

BioMed Research International

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Flagellated protozoa that cause bronchopulmonary symptoms in humans are commonly neglected. These protozoal forms which were presumed to be “flagellated protozoa” have been previously identified in immunosuppressed patients in a number of studies, but have not been certainly classified so far. Since no human cases of bronchopulmonary flagellated protozoa were reported from Turkey, we aimed to investigate these putative protozoa in immunosuppressed patients who are particularly at risk of infectious diseases. Bronchoalveolar lavage fluid samples of 110 immunosuppressed adult patients who were admitted to the Department of Chest Diseases, Hafsa Sultan Hospital of Celal Bayar University, Manisa, Turkey, were examined in terms of parasites by light microscopy. Flagellated protozoal forms were detected in nine (8.2%) of 110 cases. Metronidazole (500 mg b.i.d. for 30 days) was given to all positive cases and a second bronchoscopy was performed at the end of the treatment, which revealed no parasites. In conclusion, immunosuppressed patients with bronchopulmonary symptoms should attentively be examined with regard to flagellated protozoa which can easily be misidentified as epithelial cells.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Putative Bronchopulmonary Flagellated Protozoa in Immunosuppressed Patients

Kilimcioğlu

Havlucu

Girginkardeşler

et al. 2014

BioMed Research International

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“…In two previous studies reagents (e.g., saline, lab water, lab surfaces) have been analyzed to assess its influence on microbiota results from BAL (Bittinger et al, 2014; Krause et al, 2016); however, in other studies this was not done (Erb-Downward et al, 2011; van Woerden et al, 2011, 2013). Nevertheless, none of the studies investigating reagents showed that Candida abundance reached >50% as has been found in BAL samples from ICU patients (Krause et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Lower respiratory tract mycobiota were investigated in 30 asthma patients and compared to 13 controls (van Woerden et al, 2011, 2013). Patients were free of oral steroid use ≥2 weeks prior to induced sputum sampling but most of them were on inhaled corticosteroids.…”

Section: Mycobiome Of Patients With Asthma Bronchialementioning

confidence: 99%

Mycobiome in the Lower Respiratory Tract – A Clinical Perspective

et al. 2017

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Recently the paradigm that the healthy lung is sterile was challenged and it is now believed that the lungs harbor a diverse microbiota also contributing to the pathogenesis of various diseases. Most of the research studies targeting the respiratory microbiome have focused on bacteria and their impact on lung health and lung diseases. Recently, also the mycobiome has gained attention. Lower respiratory tract (LRT) diseases (e.g., cystic fibrosis) and other diseases or conditions (e.g., HIV infection, lung transplantation, and treatment at intensive care units) have been investigated with regard to possible involvement of mycobiome in development or progression of diseases. It has been shown that diversities of mycobiome in the LRT vary in different populations and conditions. It has been proposed that the mycobiome diversity associated with LRT can vary with different stages of diseases. Overall, Candida was the dominant fungal genus in LRT samples. In this review, we summarize the recent findings regarding the human LRT mycobiome from a clinical perspective focussing on characterization of investigated patient groups and healthy controls as well as sampling techniques. From these data, clinical implications for further studies or routine practice are drawn. To obtain clinically relevant answers efforts should be enhanced to collect well characterized and described patient groups as well as healthy individuals for comparative data analysis and to apply thorough sampling techniques. We need to proceed with elucidation of the role of mycobiota in healthy LRT and LRT diseases to hopefully improve patient care.

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“…It is possible that the organism exists as a commensal in some individuals and may only be pathogenic in the context of a causal web of aetiological factors [12]. It is also possible that more than one species is being observed which has similar features under light microscopy.…”

Section: Headingsmentioning

confidence: 99%