Association between Pruritus and Psychosocial Well-being: A Population-based Study among 6,809 Subjects

Sinikumpu, Suvi‐Päivikki; Jokelainen, Jari; Tasanen, Kaisa; Timonen, Markku; Huilaja, Laura

doi:10.2340/actadv.v103.2922

Cited by 6 publications

(4 citation statements)

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“…HE is also known as one of the most common work‐related diseases and it has significant consequences for patients' personal lives, impairing working ability, causing sick leave and even forcing patients to change their profession 9,37,38 . Bothersome symptoms of HE, such as pain and itching, cause sleep disturbances, and pruritus has been found to cause depression and anxiety in itself 39–41 . In addition, the cosmetic appearance of HE may have a significant negative effect on patients.…”

Section: Discussionmentioning

confidence: 99%

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Anxiety and depression in patients with hand eczema: A population‐based study among 853 middle‐aged subjects

Koskelo,

Sinikumpu,

Jokelainen

et al. 2023

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BackgroundHand eczema (HE) is a common dermatological disorder with considerable effect on the health‐related quality of life (HRQoL). The data on mental comorbidities of HE is sparse and mostly studied among selected patient groups.ObjectivesWe aimed to investigate symptoms of depression and anxiety in patients with HE in general population.MethodsStudy subjects (n = 6695) belonging to the Northern Finland Birth Cohort 1966 Study (NFBC1966) responded to an extensive health questionnaire including questions about HE. Depression and anxiety symptoms were evaluated according to the Hopkins Symptom Checklist‐25 (HSCL‐25).ResultsHaving ever suffered from HE was reported by 853 (12.8%) study subjects. Symptoms scores of depression were significantly higher among (n = 172, 20.3%) HE subjects compared with (n = 884, 15.4%) subjects without HE (Odds ratio [OR] 1.40, 95% confidence interval [CI]: 1.17–1.68, P < 0.001). Correspondingly, symptoms scores of anxiety were also more common among (n = 90, 10.6%) HE subjects than among (n = 448, 7.8%) subjects without HE (OR 1.40, 95% CI: 1.10–1.78, P = 0.007). In an adjusted model, the associations remained statistically significant (OR 1.30, 95% CI: 1.08–1.57, P = 0.007 and OR 1.34, 95% CI: 1.04–1.72, P = 0.021, respectively).ConclusionsSymptoms associated with mental health should be taken into account when managing patients with HE.

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Section: Discussionmentioning

confidence: 99%

“…9,37,38 Bothersome symptoms of HE, such as pain and itching, cause sleep disturbances, and pruritus has been found to cause depression and anxiety in itself. [39][40][41] In addition, the cosmetic appearance of HE may have a significant negative effect on patients.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression in patients with hand eczema: A population‐based study among 853 middle‐aged subjects

Koskelo,

Sinikumpu,

Jokelainen

et al. 2023

Contact Dermatitis

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“…The participants were asked to complete a Beck Depression Inventory II (BDI-II, cut-off < 14 and ≥ 14 points, mild/moderate/severe symptoms), Athens Insomnia Scale (AIS), Generalized Anxiety Disorder (GAD-7, cut-off ≤ 7 and ≥ 7 points), State-Trait Anxiety Inventory (STAI) and 15-dimensional measure of health-related quality of life (15D HRQoL) questionnaires to evaluate psychological symptoms in the study cases ( 15 ).…”

Section: Methodsmentioning

confidence: 99%

Adult Acne in Middle-age: Effects on Mental Health in General Population of the Northern Finland Birth Cohort 1966

Leskelä,

Jokelainen,

Huilaja

et al. 2024

Acta Derm Venereol

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The impact of adult acne on patients’ mental health has not been widely studied, and most studies have been conducted within specific patient populations. The current study examines the association between adult acne and psychological symptoms in the Northern Finland Birth Cohort 1966 (NFBC1966) (n = 1,907). The cohort members attended a health study at the age of 46 years, which comprised a whole-body examination performed by dermatologists to identify acne, and answering the Beck Depression Inventory II (BDI-II), Athens Insomnia Scale (AIS), Generalized Anxiety Disorder (GAD-7), State-Trait Anxiety Inventory (STAI) and 15-dimensional measure of health-related quality of life (15D HRQoL) questionnaires. The prevalence of adult acne was 7.9% (n = 150) with no statistical differences between the sexes. Cases with acne presented more (18.9%) depressive symptoms (BDI-II > 14 points) compared with those without acne (9.7%) (p < 0.001). In adjusted logistic regression analyses, those with acne had a 2-fold risk (odds ratio (OR) 2.08, 95% confidence interval (95% CI) 1.23–3.38) of having depressive symptoms compared with controls. In conclusion, when treating adult acne patients, it is important to recognize the increased risk of mental health symptoms.

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“…At age 46 years, MDs, including anxiety and depression, were assessed using the following four criteria: Beck Depression Inventory Second Edition (BDI-II), Generalized Anxiety Disorder Assessment (GAD-7), Hopkins Symptom Checklist (HSCL)-25, and a self-reported diagnosis with depression ( Supplementary Table S1 ) ( Guze, 1995 ; Beck et al , 1996 ). Women meeting at least two out of the four criteria were classified as the MD group ( Sinikumpu et al , 2023 ). Four participants who did not properly report the MD criteria scales were excluded ( Supplementary Fig.…”

Section: Methodsmentioning

confidence: 99%

Gut bacteriome and mood disorders in women with PCOS

Lee,

Tejesvi,

Hurskainen

et al. 2024

Human Reproduction

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STUDY QUESTION How does the gut bacteriome differ based on mood disorders (MDs) in women with polycystic ovary syndrome (PCOS), and how can the gut bacteriome contribute to the associations between these two conditions? SUMMARY ANSWER Women with PCOS who also have MDs exhibited a distinct gut bacteriome with reduced alpha diversity and a significantly lower abundance of Butyricicoccus compared to women with PCOS but without MDs. WHAT IS KNOWN ALREADY Women with PCOS have a 4- to 5-fold higher risk of having MDs compared to women without PCOS. The gut bacteriome has been suggested to influence the pathophysiology of both PCOS and MDs. STUDY DESIGN, SIZE, DURATION This population-based cohort study was derived from the Northern Finland Birth Cohort 1966 (NFBC1966), which includes all women born in Northern Finland in 1966. Women with PCOS who donated a stool sample at age 46 years (n = 102) and two BMI-matched controls for each case (n = 205), who also responded properly to the MD criteria scales, were included. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 102 women with PCOS and 205 age- and BMI-matched women without PCOS were included. Based on the validated MD criteria, the subjects were categorized into MD or no-MD groups, resulting in the following subgroups: PCOS no-MD (n = 84), PCOS MD (n = 18), control no-MD (n = 180), and control MD (n = 25). Clinical characteristics were assessed at age 31 years and age 46 years, and stool samples were collected from the women at age 46 years, followed by the gut bacteriome analysis using 16 s rRNA sequencing. Alpha diversity was assessed using observed features and Shannon’s index, with a focus on genera, and beta diversity was characterized using principal components analysis (PCA) with Bray–Curtis Dissimilarity at the genus level. Associations between the gut bacteriome and PCOS-related clinical features were explored by Spearman’s correlation coefficient. A P-value for multiple testing was adjusted with the Benjamini–Hochberg false discovery rate (FDR) method. MAIN RESULTS AND THE ROLE OF CHANCE We observed changes in the gut bacteriome associated with MDs, irrespective of whether the women also had PCOS. Similarly, PCOS MD cases showed a lower alpha diversity (Observed feature, PCOS no-MD, median 272; PCOS MD, median 208, FDR = 0.01; Shannon, PCOS no-MD, median 5.95; PCOS MD, median 5.57, FDR = 0.01) but also a lower abundance of Butyricicoccus (log-fold changeAnalysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC)=−0.90, FDRANCOM-BC=0.04) compared to PCOS no-MD cases. In contrast, in the controls, the gut bacteriome did not differ based on MDs. Furthermore, in the PCOS group, Sutterella showed positive correlations with PCOS-related clinical parameters linked to obesity (BMI, r2=0.31, FDR = 0.01; waist circumference, r2=0.29, FDR = 0.02), glucose metabolism (fasting glucose, r2=0.46, FDR < 0.001; fasting insulin, r2=0.24, FDR = 0.05), and gut barrier integrity (zonulin, r2=0.25, FDR = 0.03). LIMITATIONS, REASONS FOR CAUTION Although this was the first study to assess the link between the gut bacteriome and MDs in PCOS and included the largest PCOS dataset for the gut microbiome analysis, the number of subjects stratified by the presence of MDs was limited when contrasted with previous studies that focused on MDs in a non-selected population. WIDER IMPLICATIONS OF THE FINDINGS The main finding is that gut bacteriome is associated with MDs irrespective of the PCOS status, but PCOS may also modulate further the connection between the gut bacteriome and MDs. STUDY FUNDING/COMPETING INTEREST(S) This research was funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement (MATER, No. 813707), the Academy of Finland (project grants 315921, 321763, 336449), the Sigrid Jusélius Foundation, Novo Nordisk Foundation (NNF21OC0070372), grant numbers PID2021-12728OB-100 (Endo-Map) and CNS2022-135999 (ROSY) funded by MCIN/AEI/10.13039/501100011033 and ERFD A Way of Making Europe. The study was also supported by EU QLG1-CT-2000-01643 (EUROBLCS) (E51560), NorFA (731, 20056, 30167), USA/NIH 2000 G DF682 (50945), the Estonian Research Council (PRG1076, PRG1414), EMBO Installation (3573), and Horizon 2020 Innovation Grant (ERIN, No. EU952516). The funders did not participate in any process of the study. We have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER N/A.

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Association between Pruritus and Psychosocial Well-being: A Population-based Study among 6,809 Subjects

Cited by 6 publications

References 46 publications

Anxiety and depression in patients with hand eczema: A population‐based study among 853 middle‐aged subjects

Anxiety and depression in patients with hand eczema: A population‐based study among 853 middle‐aged subjects

Adult Acne in Middle-age: Effects on Mental Health in General Population of the Northern Finland Birth Cohort 1966

Gut bacteriome and mood disorders in women with PCOS

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