Association between psoriasis and vitamin D

Filoni, Angela; Vestita, Michelangelo; Congedo, Maurizio; Giudice, Giuseppe; Tafuri, Silvio; Bonamonte, Domenico

doi:10.1097/md.0000000000011185

Cited by 43 publications

(22 citation statements)

References 32 publications

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“…The 25-hydroxyvitamin D [25(OH)D] blood level in each group was measured and found to be significantly different in all three groups, with psoriatic patients having significantly lower vitamin D levels (21.8 ng/mL) than healthy controls (34.3 ng/mL) ( p = 0.0007). The authors of this study concluded that vitamin D level may correlate with psoriasis duration [ 131 ].…”

Section: Role Of Micronutrients In Scalp Scaling Conditionsmentioning

confidence: 99%

The Role of Vitamins and Minerals in Hair Loss: A Review

Almohanna

Ahmed

Tsatalis

et al. 2018

Dermatol Ther (Heidelb)

202

156

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People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of clinical dermatology given the prevalence of hair loss and its significant impact on patients’ quality of life. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. In this review we summarize the role of vitamins and minerals, such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc, in non-scarring alopecia. A broad literature search of PubMed and Google Scholar was performed in July 2018 to compile published articles that study the relationship between vitamins and minerals, and hair loss. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia. Given the role of vitamins and minerals in the hair cycle and immune defense mechanism, large double-blind placebo-controlled trials are required to determine the effect of specific micronutrient supplementation on hair growth in those with both micronutrient deficiency and non-scarring alopecia to establish any association between hair loss and such micronutrient deficiency. Plain Language Summary: Plain language summary available for this article.

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Section: Role Of Micronutrients In Scalp Scaling Conditionsmentioning

confidence: 99%

The Role of Vitamins and Minerals in Hair Loss: A Review

Almohanna

Ahmed

Tsatalis

et al. 2018

Dermatol Ther (Heidelb)

202

156

View full text Add to dashboard Cite

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“…However, vitamin D has shown a relevant yet controversial role in psoriasis, as well as other skin diseases [ 43 , 44 ]. In this area, Filoni et al aimed to shed some light by confirming reduced vitamin D levels in psoriatic patients and stablishing a relationship between vitamin D levels and psoriasis length [ 45 ]. Moreover, Lee et al also confirmed lower presence of 25-hydroxyvitamin D (25OHD) in psoriasis patients, 25OHD being an possible indicator of the amount of stored Vitamin D [ 46 , 47 ].…”

Section: Current Marketed Therapiesmentioning

confidence: 99%

Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

Petit

Cano

Ortiz

et al. 2021

IJMS

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Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.

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“…It is reported that serum vitamin D levels are reduced in patients with psoriasis or PSA compared to controls [ 52 , 53 ]. In addition, the decreased expression of vitamin D receptor in psoriatic skin is correlated with the reduced expression of tight junction proteins like claudins, occludins, or Zonula Occludens-1 [ 52 ].…”

Section: The Nutrients or Food Related To Psoriasismentioning

confidence: 99%

Nutrition and Psoriasis

Kanda

Hoashi

Saeki

2020

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular diseases, or inflammatory bowel diseases. Psoriasis patients often show unbalanced dietary habits such as higher intake of fat and lower intake of fish or dietary fibers, compared to controls. Such dietary habits might be related to the incidence and severity of psoriasis. Nutrition influences the development and progress of psoriasis and its comorbidities. Saturated fatty acids, simple sugars, red meat, or alcohol exacerbate psoriasis via the activation of nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 inflammasome, tumor necrosis factor-α/interleukin-23/interleukin-17 pathway, reactive oxygen species, prostanoids/leukotrienes, gut dysbiosis or suppression of regulatory T cells, while n-3 polyunsaturated fatty acids, vitamin D, vitamin B12, short chain fatty acids, selenium, genistein, dietary fibers or probiotics ameliorate psoriasis via the suppression of inflammatory pathways above or induction of regulatory T cells. Psoriasis patients are associated with dysbiosis of gut microbiota and the deficiency of vitamin D or selenium. We herein present the update information regarding the stimulatory or regulatory effects of nutrients or food on psoriasis and the possible alleviation of psoriasis by nutritional strategies.

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Association between psoriasis and vitamin D

Cited by 43 publications

References 32 publications

The Role of Vitamins and Minerals in Hair Loss: A Review

The Role of Vitamins and Minerals in Hair Loss: A Review

Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

Nutrition and Psoriasis

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