Association between pulmonary ventilatory function and mild cognitive impairment: A population-based study in rural China

Abstract

BackgroundMild cognitive impairment (MCI), a reversible intermediate state, plays an important role in the development and prevention of dementia. The relationship between pulmonary function and MCI risk has not yet been well-elucidated.MethodsWe included 2,947 rural Chinese residents aged ≥35 years who were free from a history of stroke, dementia, or other brain diseases and measured pulmonary ventilatory function using calibrated spirometry according to the recommended method. MCI was assessed with the Montreal Cognitive Assessment-Basic for Chinese scale. Logistic regression models and restricted cubic splines with covariate adjustment were performed to explore the association between pulmonary function and MCI risk.ResultsThe prevalence of MCI increased with decreasing pulmonary function, from the lowest quartile to the highest quartile of pulmonary function: 63.9, 50.5, 43.8, and 43.6%, respectively. After adjustment for confounding factors, participants in the first quartile had a significantly increased risk of MCI (ORs, 1.691, 95% CI, 1.267–2.258), with the highest quartile as the reference. In the subgroup analysis, a significant association of pulmonary function and MCI was found in females and those with low physical activity. Meanwhile, we observed an L-shaped relationship between pulmonary function and MCI (Pnon−linear = 0.032).ConclusionsPoor pulmonary function was associated with an increased risk of MCI among rural Chinese adults, and presented a non-linear relationship. These findings remind us of the need for early cognitive assessment in local populations with lower pulmonary function.

Relationship between the severity of emphysematous change in the lung and morbidity after esophagectomy for esophageal cancer: A retrospective study on a novel strategy for risk prediction

“…However, there are several limitations in the precise assessment of these indicators. Although spirometry is a useful tool for evaluating respiratory function, the results may vary based on the physical condition and cognitive ability of patients, particularly in elderly patients 20 . Emphysematous changes on CT cannot be quantified without using other equipment.…”

“…Although spirometry is a useful tool for evaluating respiratory function, the results may vary based on the physical condition and cognitive ability of patients, particularly in elderly patients. 20 Emphysematous changes on CT cannot be quantified without using other equipment. Thus, it is necessary to establish a strategy to objectively and quantitatively assess the severity of respiratory diseases associated with post‐esophagectomy morbidity.…”

review of variable risk factors affecting the development of mild cognitive impairment in older adults

“…There is growing evidence of an association between lung function decline, chronic obstructive pulmonary disease (COPD) and cognitive function [79,80]. One of the most common causes of impaired lung function is COPD.…”

Pulmonary Function Test Among University Students-A Cross Sectional Survey

“…These alterations may help to explain why men, in relation to their body size, have larger lungs since they increase the force which makes for lung expansion without correspondingly increasing the elastic rebound. 10 Gender differences in the modification of PFT parameters are poorly known. Hence, knowing the differences between the sexes in PFTPs may help in diagnosing and treating chronic respiratory problems.…”