Association Between Quantitatively Measured Infrapatellar Fat Pad High Signal‐Intensity Alteration and Magnetic Resonance Imaging–Assessed Progression of Knee Osteoarthritis

Han, Weiyu; Aitken, Dawn; Zheng, Shuang; Wluka, Anita E.; Zhu, Zhaohua; Blizzard, Leigh; Winzenberg, Tania; Cicuttini, Flavia Maria; Jones, Graeme; Ding, Changhai

doi:10.1002/acr.23713

Cited by 19 publications

(16 citation statements)

References 41 publications

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“…Secondly, IFP volume in OA patients was correlated with X-ray K-L grades [25,29]. Likewise, IFP signal intensity in OA patients was significantly correlated with knee structural abnormalities (such as knee cartilage volume, cartilage defects, and bone marrow lesions (BMLs), the occurrence of knee replacement and radiographic progression, respectively [32][33]. Thirdly, a large body of evidence indicates that MRI features of IFP may be associated with clinical symptoms in KOA patients [2,34], as summarized in Table 1.…”

Section: Involvement Of Ifp In Koa Pathogenesismentioning

confidence: 97%

Infrapatellar Fat Pad and Knee Osteoarthritis

et al. 2020

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Osteoarthritis is the most prevalent arthritis typically characterized by degradation of cartilage. However, its pathogenesis is not fully understood. Currently, osteoarthritis is best considered a disease of the whole "joint organ". Infrapatellar fat pad (IFP), an adipose tissue near synovium, is now attaching importance to researchers for its inflammatory phenotype. In this narrative review, a large body of evidence has been gathered for the involvement of IFP in the development of knee osteoarthritis. Additionally, the underlying mechanisms of how IFP can be involved in this process have been proposed. However, further investigations are needed to better understand its precise role in this process and its underlying mechanism, and beyond that, to develop new strategies to slow down the degenerative process and explore an effective and timely diagnosis of the disease.

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Section: Involvement Of Ifp In Koa Pathogenesismentioning

confidence: 97%

Infrapatellar Fat Pad and Knee Osteoarthritis

et al. 2020

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“…However, multiple studies have documented the importance of increased signal intensity within Hoffa's fat pad measured on MRI using both semi-qualitative and quantitative methods. Increased Hoffa's fat pad signal intensity, which is considered an indirect, albeit nonspecific measure of joint inflammation, was associated with the incidence of radiographic knee OA 18 , the onset of accelerated radiographic knee OA 19 , the progression of knee cartilage loss, cartilage defects, and bone marrow edema lesions on MRI 20 , and the future occurrence of total knee replacement 21 .…”

Section: Diabetes and Knee Oamentioning

confidence: 99%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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PET-MRI". Articles were reviewed to determine relevance based upon the following criteria: 1) study involved human subjects with OA or risk factors for OA and 2) study involved imaging to evaluate OA disease status or OA treatment response. Relevant articles were ranked according to scientific merit, with the best publications selected for inclusion in the narrative report. Results: The PubMed search revealed a total of 1257 articles, of which 256 (20.4%) were considered relevant to OA imaging. Two-hundred twenty-six (87.1%) articles involved the knee joint, while 195 (76.2%) articles involved the use of magnetic resonance imaging (MRI). The proportion of published studies involving the use of MRI was higher than previous years. An increasing number of articles were also published on imaging of subjects with joint injury and on deep learning application in OA imaging. Conclusion: MRI and other imaging modalities continue to play an important role in research studies designed to better understand the pathogenesis, progression, and treatment of OA.

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“…In contrast, the IPFP has been reported to be associated not only with the progression of OA, but also with its onset; thus, before measurable cartilage degeneration and many of other articular structure alteration. Finally, among all other IPFP parameters that could have been used as an outcome instead of the volume, were the tissue area and signal intensity (hypointense/hyperintense) 5,7,37,[55][56][57] . However, to date the methods used for the evaluation of those parameters have not yet been fully standardized nor a consensus established.…”

Section: Discussionmentioning

confidence: 99%

Serum adipokines/related inflammatory factors and ratios as predictors of infrapatellar fat pad volume in osteoarthritis: Applying comprehensive machine learning approaches

Bonakdari

Tardif

Abram

et al. 2020

Sci Rep

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Objective. The infrapatellar fat pad (IPFP) has been associated with knee osteoarthritis onset and progression. This study uses machine learning (ML) approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee IPFP volume of osteoarthritis patients. Methods. Serum and MRI were from the OAI at baseline. Variables comprised the 3 main osteoarthritis risk factors (age, gender, BMI), 6 adipokines, 3 inflammatory factors, and their 36 ratios. IPFP volume was assessed on MRI with a ML methodology. The best variables and models were identified in Totalcohort (n = 678), High-BMI (n = 341) and Low-BMI (n = 337), using a selection approach based on ML methods. Results. The best model for each group included three risk factors and adipsin/C-reactive protein combined for Total-cohort, adipsin/chemerin; High-BMI, chemerin/adiponectin HMW; and Low-BMI, interleukin-8. Gender separation improved the prediction (13-16%) compared to the BMI-based models. Reproducibility with osteoarthritis patients from a clinical trial was excellent (R: female 0.83, male 0.95). Pseudocodes based on gender were generated.Conclusion. This study demonstrates for the first time that the combination of the serum levels of adipokines/inflammatory factors and the three main risk factors of osteoarthritis could predict IPFP volume with high reproducibility, with the superior performance of the model accounting for gender separation.

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Association Between Quantitatively Measured Infrapatellar Fat Pad High Signal‐Intensity Alteration and Magnetic Resonance Imaging–Assessed Progression of Knee Osteoarthritis

Cited by 19 publications

References 41 publications

Infrapatellar Fat Pad and Knee Osteoarthritis

Infrapatellar Fat Pad and Knee Osteoarthritis

Osteoarthritis year in review 2019: imaging

Serum adipokines/related inflammatory factors and ratios as predictors of infrapatellar fat pad volume in osteoarthritis: Applying comprehensive machine learning approaches

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