Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese

Chu, SF; Tam, Cheuk Ming; Wong, Wilfred Hing Sang; Kam, Kai Man; Lau, YL; Chiang, Alan Kwok Shing

doi:10.1038/sj.gene.6364412

Cited by 53 publications

(68 citation statements)

References 20 publications

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“…A few studies have focused on Ϫ403G/A and Ϫ28C/G promoter variants of the RANTES gene (Table 1), providing evidence that genotypes or haplotypes derived from a combination of SNPs could confer resistance or susceptibility to TB (26,45,192). However, the actual causative variants need to be established before definitive conclusions can be made.…”

Section: Genetic Studiesmentioning

confidence: 99%

Innate Immune Gene Polymorphisms in Tuberculosis

2012

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ABSTRACTTuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single infectious agent. Recent studies targeting candidate genes and “case-control” association have revealed numerous polymorphisms implicated in host susceptibility to TB. Here, we review current progress in the understanding of causative polymorphisms in host innate immune genes associated with TB pathogenesis. We discuss genes encoding several types of proteins: macrophage receptors, such as the mannose receptor (MR, CD206), dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN, CD209), Dectin-1, Toll-like receptors (TLRs), complement receptor 3 (CR3, CD11b/CD18), nucleotide oligomerization domain 1 (NOD1) and NOD2, CD14, P2X7, and the vitamin D nuclear receptor (VDR); soluble C-type lectins, such as surfactant protein-A (SP-A), SP-D, and mannose-binding lectin (MBL); phagocyte cytokines, such as tumor necrosis factor (TNF), interleukin-1β (IL-1β), IL-6, IL-10, IL-12, and IL-18; chemokines, such as IL-8, monocyte chemoattractant protein 1 (MCP-1), RANTES, and CXCL10; and other important innate immune molecules, such as inducible nitric oxide synthase (iNOS) and solute carrier protein 11A1 (SLC11A1). Polymorphisms in these genes have been variably associated with susceptibility to TB among different populations. This apparent variability is probably accounted for by evolutionary selection pressure as a result of long-term host-pathogen interactions in certain regions or populations and, in part, by lack of proper study design and limited knowledge of molecular and functional effects of the implicated genetic variants. Finally, we discuss genomic technologies that hold promise for resolving questions regarding the evolutionary paths of the human genome, functional effects of polymorphisms, and corollary impacts of adaptation on human health, ultimately leading to novel approaches to controlling TB.

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Section: Genetic Studiesmentioning

confidence: 99%

Innate Immune Gene Polymorphisms in Tuberculosis

2012

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“…In contrast, no association of MCP-1 -2581 was found in Brazilian multicase families [41] and in a Chinese patient group from Hong Kong. [42] In the present study, it was found that the white subjects had no significant differences in frequency of the G and A alleles compared with black subjects. One can believe that, at present, the overall data do not sufficiently support any major involvement of that variant in TB susceptibility or protection.…”

Section: Discussionmentioning

confidence: 77%

Racial differences in susceptibility to infection by Mycobacterium tuberculosis

Fares¹

2012

Ann Trop Med Public Health

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Background:The prevalence of tuberculosis among blacks is known to be higher than among whites. The basis for these differences remains unclear. The purpose of this paper is to review the literature and evaluate the data which bears on the question of racial differences in susceptibility to tuberculosis. Materials and Methods: Systematic review of peer reviewed studies identified through Medline. The search was restricted to articles published in English. The references of the identified papers for further relevant publications were also reviewed. Results: For the review, 31 papers were eligible from 417 identified in the search. The prevalence of TB among black skin people was 81.5% and 18.5% in white skin people. The black subjects demonstrated higher frequency of the Fok1 E2-C4T F allele, Bsm1 E8-G-+ 284A-B allele, APa1 e9-T-48G-a allele, and Taq1 E9-T-32C-t allele and marked differences in IL-6, IL-10, TNF-α, TGF-β, and IFN-γ than white subject. There were no significant differences in MCP-1 2518 A, G allele between black and white subjects. White subjects tended to have borderline significantly higher mean serum of vitamin D (58.4 nmol/l) than black subjects (37.7 nmol/l). The capacities of skin to synthesize vitamin D Post-UVB were significantly higher in whites than in black subjects. Conclusions: Black skin people had consistently higher susceptibility to infection by M. tuberculosis than are whites skin peoples. The mechanism of a racial difference in infectibility by M. tuberculosis is the result of a complex interaction between the environmental, immunologic, and genetic factors.

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“…The African group included 5 studies [Buijtels et al, 2008;Möller et al, 2009;Thye et al, 2009;Velez Edwards et al, 2012 (2 case-control (Ben-Selma et al, 2011;Hussain et al, 2011;Arji et al, 2012). The Asian group included 10 studies (Flores-Villanueva et al, 2005;Chu et al, 2007;Alagarasu et al, 2009;Xu et al, 2009;Yang et al, 2009;Feng et al, 2011;Naderi et al, 2011;Mishra et al, 2012;Zhang et al, 2012;Singh et al, 2014). All studies analyzed the association between MCP-1 -2518A/G polymorphisms and human TB susceptibility.…”

Section: Characteristics Of Studies Includedmentioning

confidence: 99%

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

Tian¹,

Li²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The National Center for Biotechnology Information Global Cross Database and Google Scholar database were searched for relative studies. A total of 22 case-control studies that included 7332 cases and 8004 controls for the -2518A/G single-nucleotide polymorphism were identified. The results revealed an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility under a recessive model (GG vs GA+AA), dominant model (GG+GA vs AA), and homozygote comparison (GG vs AA) model for the entire database. For the dominant model, the overall odds ratio was 1.34 (95% confidence interval, 1.10-1.64, P = 0.004). For the recessive model, the overall odds ratio was 1.46 (95% confidence interval, 1.15-1.86, P = 0.002). For the homozygote comparison, the overall odds ratio was 1.67 (95% confidence interval, 1.20-2.32, P = 0.002). In the subgroup analysis by ethnicity, significantly elevated risks were found in Asians and Americans, but not in Africans and Europeans. We also used the Begg and Egger tests to examine publication bias, and no major publication bias was detected. Our results indicate that there is an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility.

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Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese

Cited by 53 publications

References 20 publications

Innate Immune Gene Polymorphisms in Tuberculosis

Innate Immune Gene Polymorphisms in Tuberculosis

Racial differences in susceptibility to infection by Mycobacterium tuberculosis

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

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