Association Between Red Blood Cells Omega-3 Polyunsaturated Fatty Acids and White Matter Hyperintensities: The MAPT Study

Moon, So Young; Barreto, Philipe de Souto; Chupin, Marie; Mangin, Jean François; Bouyahia, Ali; Fillon, Ludovic; Andrieu, Sandrine; Vellas, Bruno

doi:10.1007/s12603-017-0965-5

Cited by 9 publications

(11 citation statements)

References 23 publications

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“…In the present study, we found that the deformation of CA1 region was more significant during the transformation of MCI to AD, which was consistent with the previous studies 29 . In addition, interestingly, we found the deformation of the left hippocampus was more extensive than that of the right hippocampus, which was consistent with the previous studies 67,68 . Foley revealed that the onset of left hippocampus atrophy was earlier than that of the right hippocampus in 272 young healthy adults with higher polygenic risk scores.…”

Section: Discussionsupporting

confidence: 92%

“…29 In addition, interestingly, we found the deformation of the left hippocampus was more extensive than that of the right hippocampus, which was consistent with the previous studies. 67,68 Foley revealed that the onset of left hippocampus atrophy was earlier than that of the right hippocampus in 272 young healthy adults with higher polygenic risk scores. Moon demonstrated that the left hippocampus had a faster volume reduction than that of the right side in subjects of APOE-e4 carriers.…”

Section: Hippocampal Morphometric Differences Of Ad Vs MCI Vs Hcmentioning

confidence: 99%

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Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics

Zheng

Liu

et al. 2023

CNS Neurosci Ther

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Background Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, and mild cognitive impairment (MCI) is associated with a high risk of developing AD. Hippocampal morphometry analysis is believed to be the most robust magnetic resonance imaging (MRI) markers for AD and MCI. Multivariate morphometry statistics (MMS), a quantitative method of surface deformations analysis, is confirmed to have strong statistical power for evaluating hippocampus. Aims We aimed to test whether surface deformation features in hippocampus can be employed for early classification of AD, MCI, and healthy controls (HC). Methods We first explored the differences in hippocampus surface deformation among these three groups by using MMS analysis. Additionally, the hippocampal MMS features of selective patches and support vector machine (SVM) were used for the binary classification and triple classification. Results By the results, we identified significant hippocampal deformation among the three groups, especially in hippocampal CA1. In addition, the binary classification of AD/HC, MCI/HC, AD/MCI showed good performances, and area under curve (AUC) of triple‐classification model achieved 0.85. Finally, positive correlations were found between the hippocampus MMS features and cognitive performances. Conclusions The study revealed significant hippocampal deformation among AD, MCI, and HC. Additionally, we confirmed that hippocampal MMS can be used as a sensitive imaging biomarker for the early diagnosis of AD at the individual level.

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Section: Discussionsupporting

confidence: 92%

Section: Hippocampal Morphometric Differences Of Ad Vs MCI Vs Hcmentioning

confidence: 99%

Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics

Zheng

Liu

et al. 2023

CNS Neurosci Ther

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“…Freund-Levi et al 14 found, via subgroup analysis, that decline rate was slower in the treatment group, but only among those with the mildest AD symptoms. Moon et al 15 studied a similar population, but did not identify any positive effect of omega-3 supplementation.…”

Section: Resultsmentioning

confidence: 94%

A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes

Sherzai

2022

American Journal of Lifestyle Medicine

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Context While a great deal of interest has been accorded to the cognitive effects of n-3 long-chain polyunsaturated fatty acids (LC PUFAs), there is a need for systematic review data that assess this outcome across the lifespan, accounting for population differences and highlighting methodological limitations of extant studies. Objective This systematic review addresses the effects of n-3s on human cognition and provides an overview on the current state of research and recommendations for future efforts. Data Sources Based on a thorough review of highly powered articles from PubMed (MEDLINE), Web of Science, and ProQuest Central, the authors evaluated articles published between 2000 and 2020 assessing LC PUFA status on cognition as a primary outcome measure. Using the PRISMA guidelines, the researchers’ primary aim was to provide a comprehensive overview of the articles. Conclusions The results indicate inconsistent effects of intervention, with benefits for specific groups on specific outcomes. Although results were rarely definitive across cognitive domains, and the majority of studies indicated the presence of a possible threshold effect in which LC PUFA needs were already being met, and supplementation did not have an additional effect, there is evidence for trends towards benefit in cognitive functions, in those experiencing early cognitive decline.

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“…Similarly, Tu et al 22 reported that after feeding α-linolenic acid to weanling rats, the erythrocyte omega-3 index correlated positively with that of most other tissues, but not the brain. Some epidemiologic studies also showed no correlation between erythrocyte index and depression 39 or white matter hyperintensity 40 . Many experimental studies in animals, on the other hand, have reported a positive correlation between erythrocyte omega-3 index and that of the brain, but the range of brain DHA values achieved in these studies was narrow, since TAG-omega-3, which does not efficiently enrich brain omega-3, was used for feeding 19,22,41 .…”

Section: Discussionmentioning

confidence: 97%

Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain

Sugasini

Rao

Subbaiah

2020

Sci Rep

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Enriching brain DHA is believed to be beneficial for the prevention and treatment of several neurological diseases, including Alzheimer's disease. An impediment in assessing the effectiveness of the treatments is the lack of a reliable biomarker for brain DHA. The commonly used erythrocyte omega-3 index is not suitable for brain because of the involvement of unique transporter at the blood brain barrier (BBB). We recently showed that dietary lysophosphatidylcholine (LPC)-DHA significantly increases brain DHA, which results in increase of brain BDNF. Since there is bidirectional transport of BDNF through the BBB, we tested the hypothesis that plasma BDNF may be used as biomarker for brain DHA enrichment. We altered the brain DHA in rats and mice over a wide range using different dietary carriers of DHA, and the correlations between the increase in brain omega-3 index with the increases in plasma BDNF and the erythrocyte index were determined. Whereas the increase in brain omega-3 index positively correlated with the increase in plasma BDNF, it negatively correlated with the erythrocyte index. These results show that the plasma BDNF is more reliable than the erythrocyte index as biomarker for assessing the effectiveness of omega-3 supplements in improving brain function.

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Association Between Red Blood Cells Omega-3 Polyunsaturated Fatty Acids and White Matter Hyperintensities: The MAPT Study

Abstract: We did not find any association between omega-3 PUFAs and WMH in non-demented older adults with memory complaints. A longer longitudinal study with data on omega-3 PUFAs and WMH would contribute important information to this field.

Cited by 9 publications

References 23 publications

Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics

Classification of Alzheimer's disease based on hippocampal multivariate morphometry statistics

A Systematic Review of Omega-3 Consumption and Neuroprotective Cognitive Outcomes

Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain

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